Radiosensitization of hypoxic mammalian cells in vitro by some 5-substituted-4-nitroimidazoles was written by Adams, G. E.;Fielden, E. M.;Hardy, C.;Millar, Barbara C.;Stratford, I. J.;Williamson, Christine. And the article was included in International Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine in 1981.Formula: C4H5N3O2 This article mentions the following:
The efficiencies of various of 5-substituted 4-nitroimidazoles (I) as radiation sensitizers were determined in hypoxic Chinese hamster cells irradiated in vitro, and compared with the previously published sensitizing properties of substituted 2-nitro- and 5-nitroimidazoles, some of the I showed unusually high sensitizing efficiencies defined as the concentrations required to give an enhancement ratio of 1.6. The equilibrium 1-electron reduction potentials of the compounds (E71) were determined by a pulse radiolysis method, and the results showed that although sensitizing efficiencies were unexpectedly high, based on considerations of electron affinity, they still increase with increasing values of E71. Enhancement ratios determined in 2 V79 cell lines for combinations of one of these compounds, NSC 38O87 (I, R = SO2OPh) with various concentrations of misonidazole suggested that the 2 compounds may be operating by different mechanisms. In the experiment, the researchers used many compounds, for example, 1-Methyl-4-nitroimidazole (cas: 3034-41-1Formula: C4H5N3O2).
1-Methyl-4-nitroimidazole (cas: 3034-41-1) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with a Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).Formula: C4H5N3O2
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem