2-Amino-7-substituted benzoxazole analogs as potent RSK2 inhibitors was written by Costales, Abran;Mathur, Michelle;Ramurthy, Savithri;Lan, Jiong;Subramanian, Sharadha;Jain, Rama;Atallah, Gordana;Setti, Lina;Lindvall, Mika;Appleton, Brent A.;Ornelas, Elizabeth;Feucht, Paul;Warne, Bob;Doyle, Laura;Basham, Stephen E.;Aronchik, Ida;Jefferson, Anne B.;Shafer, Cynthia M.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2014.Electric Literature of C7H5BrN2 This article mentions the following:
2-Amino-7-substituted benzoxazole analogs were identified by HTS as inhibitors of RSK2. Mol. modeling and medicinal chem. techniques were employed to explore the SAR for this series with a focus of improving in vitro and target modulation potency and physicochem. properties. In the experiment, the researchers used many compounds, for example, 4-Bromo-1H-benzoimidazole (cas: 83741-35-9Electric Literature of C7H5BrN2).
4-Bromo-1H-benzoimidazole (cas: 83741-35-9) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole is incorporated into many important biological compounds. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Histidine is present in many proteins and enzymes, e.g. by binding metal cofactors, as seen in hemoglobin.Electric Literature of C7H5BrN2
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem