Didehydrohetarenes. XX. Reactions of 4- and 5-haloimidazoles with lithium piperidide in piperidine was written by De Bie, D. A.;Van Der Plas, H. C.;Geurtsen, G.. And the article was included in Recueil des Travaux Chimiques des Pays-Bas in 1971.Application In Synthesis of 4-Bromo-1-methylimidazole This article mentions the following:
On treatment of 5-halo-1-methyl-imidazole with lithium piperidide in piperidine, an addition-elimination reaction giving 1-methyl-5-piperidinoimidazole, transhalogenation giving 4-halo-1-methylimidazole and a meta substitution yielding the 1-methyl-2-piperidinoimidazole, were observed. No indication for the occurrence of a 4,5-didehydro-1-methylimidazole was obtained. In the experiment, the researchers used many compounds, for example, 4-Bromo-1-methylimidazole (cas: 25676-75-9Application In Synthesis of 4-Bromo-1-methylimidazole).
4-Bromo-1-methylimidazole (cas: 25676-75-9) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. Many drugs contain an imidazole ring, such as certain antifungal drugs, the nitroimidazole series of antibiotics, and the sedative midazolam.Application In Synthesis of 4-Bromo-1-methylimidazole
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem