Inhibition of the growth of Saccharomyces cerevisiae by benzimidazole was written by Evans, C. H.;Brown, E. G.. And the article was included in Biochemical Society Transactions in 1974.Application In Synthesis of 7-Methyl-1H-benzo[d]imidazole This article mentions the following:
There was no correlation between the fungistatic activities of benzimidazole derivatives and their abilities to inhibit milk xanthine oxidase (EC 1.2.3.2) [9002-17-9], suggesting that the fungistatic activity was not mediated primarily through an effect on this enzyme. Uptake of hypoxanthine-14C by untreated cells was greater than that by treated cells, but the proportion of the uric acid-xanthine-hypoxanthine were similar, 1:2.2:9.9 and 1:2.2:10.9, resp. However, treated, but not untreated, cells excreted labeled II into the culture medium. The metabolic significance of these results is discussed. In the experiment, the researchers used many compounds, for example, 7-Methyl-1H-benzo[d]imidazole (cas: 4887-83-6Application In Synthesis of 7-Methyl-1H-benzo[d]imidazole).
7-Methyl-1H-benzo[d]imidazole (cas: 4887-83-6) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with a The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.n increase of the alkyl chain length of the alcohols. Application In Synthesis of 7-Methyl-1H-benzo[d]imidazole
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem