Copper-Catalyzed Aminoheteroarylation of Unactivated Alkenes through Distal Heteroaryl Migration was written by Kwon, Yungeun;Zhang, Wei;Wang, Qiu. And the article was included in ACS Catalysis in 2021.Application In Synthesis of 1-Methylbenzimidazole This article mentions the following:
A copper-catalyzed aminoheteroarylation of unactivated alkenes to access valuable heteroarylethylamine motif. was reported. The developed reaction features a copper-catalyzed intermol. electrophilic amination of the alkenes followed by a migratory heteroarylation. The method applies to alc.-, amide-, and ether-containing alkenes, overcoming the common requirement of a hydroxyl motif in previous migratory difunctionalization reactions. This reaction was effective for the introduction of diverse aliphatic amines and has good functional group tolerance, which was particularly useful for rich functionalized heteroarenes. This migration-involved reaction was found well suited as a powerful ring-expansion approach for the construction of medium-sized rings that were in great demand in medicinal chem. In the experiment, the researchers used many compounds, for example, 1-Methylbenzimidazole (cas: 1632-83-3Application In Synthesis of 1-Methylbenzimidazole).
1-Methylbenzimidazole (cas: 1632-83-3) belongs to imidazole derivatives. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs. Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.Application In Synthesis of 1-Methylbenzimidazole
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem