Chlorodifluoromethane as a C1 Synthon in the Assembly of N-Containing Compounds was written by Ma, Xingxing;Su, Jianke;Zhang, Xingang;Song, Qiuling. And the article was included in iScience in 2019.Recommanded Product: 7-Methyl-1H-benzo[d]imidazole This article mentions the following:
A quadruple cleavage of chlorodifluoromethane to yield a C1 source, which was successfully employed in the construction of various N-containing compounds e.g., C6H5N(CH3)CH=NC6H5 especially with pharmaceutical mols. under mild conditions was reported. This strategy provides a useful method for late-stage modification of pharmaceutical compounds Four bonds in ClCF2H were orderly cleaved under basic conditions in the absence of transition metals. Preliminary mechanistic studies revealed that (E)-N-phenylformimidoyl fluoride intermediate is involved in this process by in situ 1H NMR studies and control experiments In the experiment, the researchers used many compounds, for example, 7-Methyl-1H-benzo[d]imidazole (cas: 4887-83-6Recommanded Product: 7-Methyl-1H-benzo[d]imidazole).
7-Methyl-1H-benzo[d]imidazole (cas: 4887-83-6) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole is incorporated into many important biological compounds. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Histidine is present in many proteins and enzymes, e.g. by binding metal cofactors, as seen in hemoglobin.Recommanded Product: 7-Methyl-1H-benzo[d]imidazole
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem