A new class of benzoin condensation catalysts: N,N’-disubstituted o-phenylenediamines was written by Morkovnik, Anatolli S.;Khrustalev, Viktor N.;Lindeman, Sergei V.;Struchkov, Yuril T.;Morkovnik, Zinaida S.. And the article was included in Mendeleev Communications in 1995.Quality Control of 1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde This article mentions the following:
N,N’-dialkyl(diaralkyl)-o-phenylenediamine 1-R1NHC6H4NHR2-2 (R1 = R2 = Me, Et, CH2Ph; R1 = Et, R2 = allyl) act as effective catalysts in benzoin condensation of heterocyclic aldehydes I (X = NMe, NEt, Se) to give dihydroxy alkene products II. In the experiment, the researchers used many compounds, for example, 1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde (cas: 3012-80-4Quality Control of 1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde).
1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde (cas: 3012-80-4) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes.Quality Control of 1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem