Reactions of 2-dichloromethylbenzimidazole with certain primary amines was written by Pascal, Robert A. Jr.;Jungk, Steven;Risinger, G. E.. And the article was included in Journal of Heterocyclic Chemistry in 1978.Safety of 1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde This article mentions the following:
An investigation of the reactions of 2-(2,2-dichloromethyl)benzimidazole (I) with primary amines gave 2-(N–tert-butylformimidoyl)benzimidazole, 2-N-(2-phenylethyl)formimdoylbenzimidazole, and 1-(ethoxycarbonylmethyl)-2-(N–tert-butylformimidoyl)benzimidazole. Under mild alkali conditions, I was rapidly converted into a dimer, 6H,13H-pyrazino[1,2-a:4,5-a‘]bisbenzimidazole-6,13-diol. In the experiment, the researchers used many compounds, for example, 1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde (cas: 3012-80-4Safety of 1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde).
1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde (cas: 3012-80-4) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with a Imidazole also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes.Safety of 1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem