Simple protic ionic liquid [Et3NH][HSO4] as a proficient catalyst for facile synthesis of biscoumarins was written by Patil, Sandip K.;Awale, Deepak V.;Vadiyar, Madagonda M.;Patil, Suryakant A.;Bhise, Sagar C.;Kolekar, Sanjay S.. And the article was included in Research on Chemical Intermediates in 2017.HPLC of Formula: 35487-17-3 This article mentions the following:
Abstract: We have explored a number of protic ionic liquids (PILs) as a catalyst for the synthesis of biscoumarins by condensation of 4-hydroxycoumarin with an aromatic aldehyde. Methylimidazolium- and triethylammonium-based PILs were synthesized by simple neutralization reaction with protic acids. Triethylammonium hydrogen sulfate [Et3NH][HSO4] was found to be the best among the studied PILs concerning the yield of products and reaction time period. Different biscoumarin derivatives were synthesized based on 4-hydroxycoumarin and various substituted aromatic aldehydes at optimum reaction conditions. Obtained products were separated just by simple filtration. The facile method does not require addnl. purification for formed products. The catalyst has shown better yields along with outstanding recyclability, providing an environmental benign protocol for the synthesis of biscoumarin derivatives Graphical Abstract: Screening of simple protic ionic liquids as a catalyst in the synthesis of biscoumarins, out of which [Et3NH][HSO4] was found to be best among the studied PILs. [Figure not available: see fulltext.]. In the experiment, the researchers used many compounds, for example, 1-Methyl-1H-imidazol-3-ium chloride (cas: 35487-17-3HPLC of Formula: 35487-17-3).
1-Methyl-1H-imidazol-3-ium chloride (cas: 35487-17-3) belongs to imidazole derivatives. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs. Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.HPLC of Formula: 35487-17-3
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem