Discovery of a novel highly potent broad-spectrum heterocyclic chemical series of arenavirus cell entry inhibitors was written by Plewe, Michael B.;Gantla, Vidyasagar Reddy;Sokolova, Nadezda V.;Shin, Young-Jun;Naik, Shibani;Brown, Eric R.;Fetsko, Alexandra;Zhang, Lihong;Kalveram, Birte;Freiberg, Alexander N.;Henkel, Greg;McCormack, Ken. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2021.Recommanded Product: 6-Bromo-8-methylimidazo[1,2-a]pyridine This article mentions the following:
We identified and explored the structure-activity relationship (SAR) of a novel heterocyclic chem. series of arenavirus cell entry inhibitors. Optimized lead compounds, including diphenyl-substituted imidazo[1,2-a]pyridines, benzimidazoles, and benzotriazoles exhibited low to sub-nanomolar potency against both pseudotyped and infectious Old and New World arenaviruses, attractive metabolic stability in human and most nonhuman liver microsomes as well as a lack of hERG K + channel or CYP enzyme inhibition. Moreover, the straightforward synthesis of several lead compounds (e.g., the simple high yield 3-step synthesis of imidazo[1,2-a]pyridine I) could provide a cost-effective broad-spectrum arenavirus therapeutic that may help to minimize the cost-prohibitive burdens associated with treatments for emerging viruses in economically challenged geog. settings. In the experiment, the researchers used many compounds, for example, 6-Bromo-8-methylimidazo[1,2-a]pyridine (cas: 217435-65-9Recommanded Product: 6-Bromo-8-methylimidazo[1,2-a]pyridine).
6-Bromo-8-methylimidazo[1,2-a]pyridine (cas: 217435-65-9) belongs to imidazole derivatives. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs. Imidazole also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes.Recommanded Product: 6-Bromo-8-methylimidazo[1,2-a]pyridine
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem