Roffia, S. et al. published their research in Journal of Electroanalytical Chemistry and Interfacial Electrochemistry in 1982 | CAS: 3034-41-1

1-Methyl-4-nitroimidazole (cas: 3034-41-1) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole has been usedin the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein, in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography, as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells.Safety of 1-Methyl-4-nitroimidazole

Electrochemical behavior of 4-nitroimidazole and 2-methyl-5-nitroimidazole. Autoprotonation of anion radical and redox-catalyzed reduction of the supporting electrolyte cation was written by Roffia, S.;Gottardi, C.;Vianello, E.. And the article was included in Journal of Electroanalytical Chemistry and Interfacial Electrochemistry in 1982.Safety of 1-Methyl-4-nitroimidazole This article mentions the following:

The electrochem. behavior of the title imidazoles (HRNO2) was studied in DMF and MeCN by polarog., cyclic voltammetry and controlled-potential electrolysis and coulometry. The above nitroimidazoles present similar behavior, displaying 2 reduction waves paralleled by 2 reduction peaks in linear sweep voltammetry. The 1st peak is irreversible up to a sweep rate of 250 V s-1, while the 2nd one appears voltammetry. The exptl. data in the 1st process are consistent with the hypothesis that the irreversibility of the 1st wave is due to a rapid decay of the primary anion radical of HRNO2 because of a fast protonation reaction by the starting nitroimidazole, with the formation of the conjugate base RNO2– and of the neutral radical of HRNO2H. This last radical gives rise, as final reduction product, to the hydroxylamino derivative, the necessary protons being supplied by the starting HRNO2. The 2nd process is attributable to the reduction of RNO2– to radical dianion of RNO2. The complete mechanism is discussed in detail. In the experiment, the researchers used many compounds, for example, 1-Methyl-4-nitroimidazole (cas: 3034-41-1Safety of 1-Methyl-4-nitroimidazole).

1-Methyl-4-nitroimidazole (cas: 3034-41-1) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole has been usedin the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein, in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography, as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells.Safety of 1-Methyl-4-nitroimidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem