Palladium-Catalyzed Ligand-Free C-N Coupling Reactions: Selective Diheteroarylation of Amines with 2-Halobenzimidazoles was written by Sang, Wei;Gavi, Ayao Jean;Yu, Bao-Yi;Cheng, Hua;Yuan, Ye;Wu, Yuan;Lommens, Petra;Chen, Cheng;Verpoort, Francis. And the article was included in Chemistry – An Asian Journal in 2020.Computed Properties of C8H8N2 This article mentions the following:
Considering the potential values of the di-substituted products I (R1 = H, Me, Cl; R2 = Me, Et, iBu, iPr, phenyl; R3 = 4-bromophenyl, 3-methylphenyl, 4-methoxyphenyl, etc.), the first selective diheteroarylation of amines R3NH2 with 2-halobenzimidazoles II has been reported. Notably, this Pd-catalyzed transformation was realized under ligand-free conditions. Accordingly, numerous target products were efficiently produced from various aromatic or aliphatic amines R3NH2 and 2-halobenzimidazoles II. It was worth noting that two representative products were further confirmed by X-ray crystallog. More significantly, this catalytic process could be applied to the synthesis and discovery of new bioactive compounds, which demonstrated the synthetic usefulness of this newly developed approach. In the experiment, the researchers used many compounds, for example, 1-Methylbenzimidazole (cas: 1632-83-3Computed Properties of C8H8N2).
1-Methylbenzimidazole (cas: 1632-83-3) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. Imidazole also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes.Computed Properties of C8H8N2
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem