Enantioselective Nickel-Catalyzed Michael Additions of 2-Acetylazaarenes to Nitroalkenes was written by Simpson, Alain J.;Lam, Hon Wai. And the article was included in Organic Letters in 2013.Electric Literature of C6H8N2O This article mentions the following:
2-Acetylazaarenes undergo catalytic enantioselective Michael additions to nitroalkenes in the presence of a chiral Ni(II)-bis(oxazoline) complex [e.g., 2-acetylpyridine + trans-β-nitrostyrene → (R)-4-nitro-3-phenyl-1-(pyridin-2-yl)-1-one]. The process is tolerant of a range of azines or azoles in the pronucleophilic component, resulting in Michael products in moderate to high enantioselectivities. In the experiment, the researchers used many compounds, for example, 1-(1-Methyl-1H-imidazol-2-yl)ethanone (cas: 85692-37-1Electric Literature of C6H8N2O).
1-(1-Methyl-1H-imidazol-2-yl)ethanone (cas: 85692-37-1) belongs to imidazole derivatives. Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar. Imidazole also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes.Electric Literature of C6H8N2O
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem