Month: December 2022

Radical Cascade Multicomponent Minisci Reactions with Diazo Compounds was written by Su, Yong-Liang;Liu, Geng-Xin;De Angelis, Luca;He, Ru;Al-Sayyed, Ammar;Schanze, Kirk S.;Hu, Wen-Hao;Qiu, Huang;Doyle, Michael P.. And the article was included in ACS Catalysis in 2022.Electric Literature of C8H8N2 This article mentions the following:

Based on the strategy of polarity reversal in the generation of free radicals derived from diazo compounds, R¹C(=N₂)R²[R¹ = ethoxycarbonyl, (benzyloxy)carbonyl, N,N-diethylcarbamoyl, etc.; R² = H, C(O)OMe] photocatalyzed multicomponent reactions (MCRs) of nitrogen aromatic heterocycles, e.g., 4-methylquinoline, alkenes R³CH=CH₂ [R³ = methoxymethyl, cyclohexyl, 4-[(furan-2-yl)carbonyloxy]butyl, etc.], and diazo compounds form functionalized derivatives e.g., Et 4-(4-methylquinolin-2-yl)-6-phenylhexanoate in good to high yields and exacting regioselectivities. The carbon radicals generated from the acceptor diazo compounds are electrophilic, and their selective additions with alkenes provide nucleophilic radicals, which enable the further rapid assembly with various heteroarenes. A delicate balance has been achieved between the activation of heteroarenes through protonation and the decomposition of diazo compounds by the same acid. This multicomponent Minisci reaction shows high functional group tolerance, especially in the incorporation of biol. active mols. Detailed mechanistic studies that include photophys. measurements elaborate this radical cascade reaction. Furthermore, this transformation provides new opportunities for versatile reactions of diazo compounds in radical cascade multicomponent coupling reactions. In the experiment, the researchers used many compounds, for example, 1-Methylbenzimidazole (cas: 1632-83-3Electric Literature of C8H8N2).

1-Methylbenzimidazole (cas: 1632-83-3) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.n increase of the alkyl chain length of the alcohols. Electric Literature of C8H8N2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

CO₂ as a C1 Source: B(C₆F₅)₃-Catalyzed Cyclization of o-Phenylene-diamines To Construct Benzimidazoles in the Presence of Hydrosilane was written by Zhang, Zhenbei;Sun, Qiangsheng;Xia, Chungu;Sun, Wei. And the article was included in Organic Letters in 2016.Computed Properties of C8H8N2 This article mentions the following:

The catalytic construction of benzimidazoles using CO₂ as a carbon source represents a facile and sustainable approach to obtaining these valuable compounds Herein, we describe the B(C₆F₅)₃-catalyzed synthesis of benzimidazoles via cyclization of o-phenylenediamines with CO₂ and PhSiH₃. This metal-free catalytic route achieves the desired products in high yield under convenient reaction conditions and is applicable to a broad substrate scope. A plausible mechanism for the reaction involving a frustrated Lewis pair pathway is proposed based on spectroscopic characterization (e.g., ¹³C NMR) of the reaction intermediates. In the experiment, the researchers used many compounds, for example, 7-Methyl-1H-benzo[d]imidazole (cas: 4887-83-6Computed Properties of C8H8N2).

7-Methyl-1H-benzo[d]imidazole (cas: 4887-83-6) belongs to imidazole derivatives. Imidazole is the basic core of some natural products such as histidine, purine, histamine and DNA based structures, etc. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).Computed Properties of C8H8N2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Electronic structure-activity relationships for propenone derivatives. II. 2-Cinnamoylbenzimidazoles and 2-(β-benzoylvinyl)-1-methylbenzimidazoles was written by Oganesyan, E. T.;Pogrebnyak, A. V.;Shiryaev, I. N.;Saraf, A. S.;Ivashev, M. N.. And the article was included in Khimiko-Farmatsevticheskii Zhurnal in 1995.Application In Synthesis of 1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde This article mentions the following:

Synthesis of the title propenone derivatives as well as their sedative and antiallergic activities as functions of their electronic structure are described. In the experiment, the researchers used many compounds, for example, 1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde (cas: 3012-80-4Application In Synthesis of 1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde).

1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde (cas: 3012-80-4) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.Application In Synthesis of 1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Development of ionic liquid-mediated antibacterial cellulose-chitosan films was written by Zhou, Yonghui;Luo, Xiaolin;Huang, Liulian;Lin, Shan;Chen, Lihui. And the article was included in Journal of Biobased Materials and Bioenergy in 2015.HPLC of Formula: 35487-17-3 This article mentions the following:

The solubility of cellulose, chitosan and their composites has been investigated to understand their roles in the formulation of antibacterial cellulose-chitosan composite films and their contributions to the performance of the films. Antibacterial and homogeneous cellulose-chitosan composite films with high mech. property were successfully prepared by co-dissolving cellulose and chitosan in 1-ethyl-3-methylimidazolium acetate (EmimAc) ionic liquid The composite films were further characterized by using XRD, TGA, FTIR, SEM, mech. strength and antibacterial ability measurements. XRD anal. of the films suggested that the structure of crystalline as well as crystallinities of both polymers changed during the processes of dissolution and regeneration, although their solubility varies considerably. The developed films were thermally more stable than the regenerated cellulose or chitosan itself. Hydrogen bonding between cellulose and chitosan in the blend films was determined by FTIR. SEM images also revealed a homogeneous and compact structure of the blend films. In addition, cellulose-chitosan composite films showed highly inhibitory effects on the bacteria of E. coli. and S. aureus. In the experiment, the researchers used many compounds, for example, 1-Methyl-1H-imidazol-3-ium chloride (cas: 35487-17-3HPLC of Formula: 35487-17-3).

1-Methyl-1H-imidazol-3-ium chloride (cas: 35487-17-3) belongs to imidazole derivatives. Imidazole is the basic core of some natural products such as histidine, purine, histamine and DNA based structures, etc. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole is incorporated into many important biological compounds. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Histidine is present in many proteins and enzymes, e.g. by binding metal cofactors, as seen in hemoglobin.HPLC of Formula: 35487-17-3

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Evaluation of a simple disposable microband electrode device for amperometric gas sensing was written by Xiong, Linhongjia;Goodrich, Peter;Hardacre, Christopher;Compton, Richard G.. And the article was included in Sensors and Actuators, B: Chemical in 2013.Reference of 79917-89-8 This article mentions the following:

The authors report a simple and facile methodol. for constructing Pt (6.3 mm × 50 μm) and Cu (6.3 mm × 30 μm) annular microband electrodes for use in room temperature ionic liquids (RTILs) and propose their use for amperometric gas sensing. The suitability of microband electrodes for use in electrochem. anal. was examined in experiments on two systems. The 1st system studied to validate the electrochem. responses of the annular microband electrode was decamethylferrocene (DmFc), as a stable internal reference probe commonly used in ionic liquids, in [Pmim][NTf₂], where the diffusion coefficients of DmFc and DmFc⁺ and the standard electron rate constant for the DmFc/DmFc⁺ couple were determined through fitting chronoamperometric and cyclic voltammetric responses with relevant simulations. These values are independently compared with those collected from a com. available Pt microdisc electrode with excellent agreement. The 2nd system focuses on O₂ reduction in [Pmim][NTf₂], which is used as a model for gas sensing. The diffusion coefficients of O₂ and O₂^– and the electron transfer rate constant were again obtained using chronoamperometry and cyclic voltammetry, along with simulations. Results determined from the microbands are again consistent to those evaluated from the Pt microdisc electrode when compared these results from home-made microband and com. available microdisc electrodes. The fabricated annular microband electrodes are suitable for quant. measurements. Further the successful use of the Cu electrodes in the O₂ system suggests a cheap disposable sensor for gas detection. In the experiment, the researchers used many compounds, for example, 1-Methyl-3-propylimidazolium Chloride (cas: 79917-89-8Reference of 79917-89-8).

1-Methyl-3-propylimidazolium Chloride (cas: 79917-89-8) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Many drugs contain an imidazole ring, such as certain antifungal drugs, the nitroimidazole series of antibiotics, and the sedative midazolam.Reference of 79917-89-8

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Amino-catalyzed hydrolysis of amides and esters in the fragmentation by electrospray ionization tandem mass spectrometry using an ion trap was written by Yang, Xiaoli;Zhu, Changjin;Cao, Shuxia;Liao, Xinchen;Jiang, Yanfeng;Zhao, Yufen. And the article was included in Rapid Communications in Mass Spectrometry in 2003.Recommanded Product: 169770-25-6 This article mentions the following:

Neutral mass losses from mass-selected precursors in the ESI-MS/MS of monoimidazole polyamine amides and monoimidazole esters were attributed to hydrolysis by water (in the ion trap) and catalyzed by intramol. amino groups. In the experiment, the researchers used many compounds, for example, Methyl 1-methyl-4-nitro-1H-imidazole-2-carboxylate (cas: 169770-25-6Recommanded Product: 169770-25-6).

Methyl 1-methyl-4-nitro-1H-imidazole-2-carboxylate (cas: 169770-25-6) belongs to imidazole derivatives. Imidazole is the basic core of some natural products such as histidine, purine, histamine and DNA based structures, etc. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes.Recommanded Product: 169770-25-6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Survey to identify substandard and falsified tablets in several Asian countries with pharmacopeial quality control tests and principal component analysis of handheld Raman spectroscopy was written by Kakio, Tomoko;Nagase, Hitomi;Takaoka, Takashi;Yoshida, Naoko;Hirakawa, Junichi;Macha, Susan;Hiroshima, Takashi;Ikeda, Yukihiro;Tsuboi, Hirohito;Kimura, Kazuko. And the article was included in American Journal of Tropical Medicine and Hygiene in 2018.Application of 145040-37-5 This article mentions the following:

The World Health Organization has warned that substandard and falsified medical products (SFs) can harm patients and fail to treat the diseases for which they were intended, and they affect every region of the world, leading to loss of confidence in medicines, health-care providers, and health systems. Therefore, development of anal. procedures to detect SFs is extremely important. In this study, we investigated the quality of pharmaceutical tablets containing the antihypertensive candesartan cilexetil, collected in China, Indonesia, Japan, and Myanmar, using the Japanese pharmacopeial anal. procedures for quality control, together with principal component anal. (PCA) of Raman spectrum obtained with handheld Raman spectrometer. Some samples showed delayed dissolution and failed to meet the pharmacopeial specification, whereas others failed the assay test. These products appeared to be substandard. Principal component anal. showed that all Raman spectra could be explained in terms of two components: the amount of the active pharmaceutical ingredient and the kinds of excipients. Principal component anal. score plot indicated one substandard, and the falsified tablets have similar principal components in Raman spectra, in contrast to authentic products. The locations of samples within the PCA score plot varied according to the source country, suggesting that manufacturers in different countries use different excipients. Our results indicate that the handheld Raman device will be useful for detection of SFs in the field. Principal component anal. of that Raman data clarify the difference in chem. properties between good quality products and SFs that circulate in the Asian market. In the experiment, the researchers used many compounds, for example, 1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate (cas: 145040-37-5Application of 145040-37-5).

1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate (cas: 145040-37-5) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with a The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.n increase of the alkyl chain length of the alcohols. Application of 145040-37-5

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Aqueous biphasic systems composed of ionic liquids and polypropylene glycol: insights into their liquid-liquid demixing mechanisms was written by Neves, Catarina M. S. S.;Shahriari, Shahla;Lemus, Jesus;Pereira, Jorge F. B.;Freire, Mara G.;Coutinho, Joao A. P.. And the article was included in Physical Chemistry Chemical Physics in 2016.Electric Literature of C7H13ClN2 This article mentions the following:

Novel ternary phase diagrams of aqueous biphasic systems (ABSs) composed of polypropylene glycol with an average mol. weight of 400 g mol^-1 (PPG-400) and a vast number of ionic liquids (ILs) were determined The large array of selected ILs allowed us to evaluate their tuneable structural features, namely the effect of the anion nature, cation core and cation alkyl side chain length on the phase behavior. Addnl. evidence on the mol.-level mechanisms which rule the phase splitting was obtained by ¹H NMR (NMR) spectroscopy and by COSMO-RS (Conductor-like Screening Model for Real Solvents). Some systems, for which the IL-PPG-400 pairs are completely miscible, revealed to be of type “0”. All data collected suggest that the formation of PPG-IL-based ABSs is controlled by the interactions established between the IL and PPG, contrarily to previous reports where a “salting-out” phenomenon exerted by the IL over the polymer in aqueous media was proposed as the dominant effect in ABS formation. The influence of temperature on the liquid-liquid demixing was also evaluated. In general, an increase in temperature favors the formation of an ABS in agreement with the lower critical solution temperature (LCST) phase behavior usually observed in polymer-IL binary mixtures Partition results of a dye (chloroanilic acid, in its neutral form) further confirm the possibility of tailoring the phases’ polarities of IL-PPG-based ABSs. In the experiment, the researchers used many compounds, for example, 1-Methyl-3-propylimidazolium Chloride (cas: 79917-89-8Electric Literature of C7H13ClN2).

1-Methyl-3-propylimidazolium Chloride (cas: 79917-89-8) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with a Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).Electric Literature of C7H13ClN2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Condensed 1,3,5-triazepines – IV. The synthesis of 2,3-dihydro-1H-imidazo[1,2-a][1,3,5]benzotriazepines was written by Agai, B.;Hornyak, G.;Lempert, K.;Simig, G.. And the article was included in Periodica Polytechnica, Chemical Engineering in 1982.Product Details of 24134-26-7 This article mentions the following:

Imidazobenzotriazepines I (R = H, Bu; R¹ = H, Me; R² = H, 8-Cl, 8-BuNHCO) were prepared by cyclizing imines II (R³ = NH₂) (III), obtained by catalytic hydrogenation of II (R³ = NO₂), with R¹C(OEt)₃. I (R = H, Bu; R¹ = SMe; R² = H, 8-MeO, 8-MeO₂C, 8-Cl, 9-Cl, 8-BuNHCO) were prepared by S-methylating the thiones prepared by cyclizing III with Cl₂CS. I (R = H, Bu; R¹ = NHBu, morpholino, 4-methylpiperazino; R² = H, 8-MeO, 8-Cl, 9-Cl, 8-BuNHCO) were obtained by aminating I (R¹ = SMe). In the experiment, the researchers used many compounds, for example, 2,3-Dihydro-1H-benzo[d]imidazo[1,2-a]imidazole (cas: 24134-26-7Product Details of 24134-26-7).

2,3-Dihydro-1H-benzo[d]imidazo[1,2-a]imidazole (cas: 24134-26-7) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with a Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.Product Details of 24134-26-7

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Expedient synthesis of gem-dialkylbenzyl heterocycles through olefinic hydroarylation was written by Lian, Yajing;Burford, Kristen;Londregan, Allyn T.. And the article was included in Tetrahedron in 2015.Name: 4-Bromo-1-methylimidazole This article mentions the following:

A robust approach to gem-dialkylbenzyl heterocycles has been developed through a triflic acid-catalyzed hydroarylation of olefinic heterocycles. A broad range of substrates containing pyridine, quinoline, pyrazole, triazole and imidazole moieties are shown to be highly compatible with this method. This rapid construction of gem-dialkyl groups should be useful in the synthesis of drug-like mols. containing heterocyclic diversity and in the study of the gem-dialkyl effect. In the experiment, the researchers used many compounds, for example, 4-Bromo-1-methylimidazole (cas: 25676-75-9Name: 4-Bromo-1-methylimidazole).

4-Bromo-1-methylimidazole (cas: 25676-75-9) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. Imidazole also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes.Name: 4-Bromo-1-methylimidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem