Month: December 2022

Modification of Yttrium Silyl-Bridged Amide Alkyl Complexes through Si-H/C-H Cross-Dehydrocoupling of Silanes with a Silylamino Ligand: Synthesis, Reactivity, and Mechanism was written by You, Qing;Zhang, Jie;Zhou, Xigeng. And the article was included in Chemistry – A European Journal in 2020.COA of Formula: C8H8N2 This article mentions the following:

A new method for the modification of a silylamino ligand was developed through mono and dual C(sp³)-H/Si-H cross-dehydrocoupling with silanes. The reaction of [LY{η²-(C,N)-CH₂Si(Me₂)NSiMe₃}] (L = bis(2,6-diisopropylphenyl)-β-diketiminato, L’ (2^L’); L = Tp^Me2 (2^TpMe2)). Also, 1^TpMe2 reacted with the secondary silanes Ph₂SiH₂ and Et₂SiH₂ to afford the corresponding mono C-H activation products [Tp^Me2Y{η²-(C,N)-CH(SiHR₂)Si(Me₂)NSiMe₃}] (R = Ph (4b); R = Et (4c)). The equimolar reaction of 1^TpMe2 with PhSiH₃ also produced the mono C-H activation product 4a ([Tp^Me2Y{η²-(C,N)-CH(SiH₂Ph)Si(Me₂)NSiMe₃}(THF)]). A study of their reactivity showed that 4a facilely reacted with 2 equiv of benzothiazole by an unusual 1,1-addition of the C:N bond of the benzothiazolyl unit to the Si-H bond to give the C-H/Si-H cross-dehydrocoupling product [(Tp^Me2)Y{η³-(N,N,N)-N(SiMe₃)SiMe₂CH₂Si(Ph)(CSC₆H₄N)(CHSC₆H₄N)}] (5). This modification endows the silylamino ligand with novel reactivity. In the experiment, the researchers used many compounds, for example, 1-Methylbenzimidazole (cas: 1632-83-3COA of Formula: C8H8N2).

1-Methylbenzimidazole (cas: 1632-83-3) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with a Many drugs contain an imidazole ring, such as certain antifungal drugs, the nitroimidazole series of antibiotics, and the sedative midazolam.COA of Formula: C8H8N2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Microfibers of embellished cobalt-zeolite imidazole framework for vitamin-B2 detection was written by Girija, S.;Sankar, S. Sam;Kundu, Subrata;Wilson, J.. And the article was included in Journal of the Electrochemical Society in 2020.Product Details of 1632-83-3 This article mentions the following:

Co-Zeolite Imidazole Framework (Co-ZIF) microfibers were synthesized by electrospinning method used for the quantification of Riboflavin (RF). Co ions are tethered uniformly along the surface of the ZIF by electrostatic attraction. Crystalline Co ions are interconnected with ZIFs, which makes strongly bonded tetrahedral structure of Co-ZIF providing the improved stability in the composite. The cyclic voltammetric profile reveals, excellent catalytic behavior of the electrodes and the linear plot evidences for interfacial electron transfer of RF to Co-ZIF microfiber modified GCE surface. A selective determination of RF with the linear range of 100 nM to 1 mM with the low limit detection of 81 nM by square wave voltammetry (SWV) technique is demonstrated. The developed RF sensor shows anti-interference ability towards other electroactive species and it was successfully employed toward the real sample for the detection of RF with good recovery result. In the experiment, the researchers used many compounds, for example, 1-Methylbenzimidazole (cas: 1632-83-3Product Details of 1632-83-3).

1-Methylbenzimidazole (cas: 1632-83-3) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with a Many drugs contain an imidazole ring, such as certain antifungal drugs, the nitroimidazole series of antibiotics, and the sedative midazolam.Product Details of 1632-83-3

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Improvement of the cloud point extraction of uranyl ions by the addition of ionic liquids was written by Gao, Song;Sun, Taoxiang;Chen, Qingde;Shen, Xinghai. And the article was included in Journal of Hazardous Materials in 2013.Recommanded Product: 404001-48-5 This article mentions the following:

The cloud point extraction (CPE) of uranyl by different kinds of extractants in Triton X-114 (TX-114) micellar solution was studied upon the addition of ionic liquids (ILs) with various anions, i.e., Br^–, BF₄^–, PF₆^– and bis[(trifluoromethyl)sulfonyl]imide (NTf₂^–). A significant increase of the extraction efficiency was found on the addition of NTf₂^– based ILs when using neutral extractant tri-octylphosphine oxide (TOPO), and the extraction efficiency kept high at both nearly neutral and high acidity. However, the CPE with acidic extractants, e.g., bis(2-ethylhexyl) phosphoric acid (HDEHP) and 8-hydroxyquinoline (8-HQ) which are only effective at nearly neutral condition, was not improved by ILs. The results of zeta potential and ¹⁹F NMR measurements indicated that the anion NTf₂^– penetrated into the TX-114 micelles and was enriched in the surfactant-rich phase during the CPE process. Meanwhile, NTf₂^– may act as a counterion in the CPE of UO₂²⁺ by TOPO. The addition of IL increased the separation factor of UO₂²⁺ and La³⁺, which implied that in the micelle TOPO, NTf₂^– and NO₃^– established a soft template for UO₂²⁺. Therefore, the combination of CPE and IL provided a supramol. recognition to concentrate UO₂²⁺ efficiently and selectively. In the experiment, the researchers used many compounds, for example, 3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide (cas: 404001-48-5Recommanded Product: 404001-48-5).

3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide (cas: 404001-48-5) belongs to imidazole derivatives. Imidazole is the basic core of some natural products such as histidine, purine, histamine and DNA based structures, etc. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole is incorporated into many important biological compounds. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Histidine is present in many proteins and enzymes, e.g. by binding metal cofactors, as seen in hemoglobin.Recommanded Product: 404001-48-5

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Examining the unique retention behavior of volatile carboxylic acids in gas chromatography using zwitterionic liquid stationary phases was written by Nan, He;Kuroda, Kosuke;Takahashi, Kenji;Anderson, Jared L.. And the article was included in Journal of Chromatography A in 2019.Safety of 1-Octyl-1H-imidazole This article mentions the following:

For the first time, gas chromatog. (GC) stationary phases consisting of zwitterionic liquids (ZILs) possessing sulfonate functional groups were utilized for the anal. of volatile carboxylic acids (VCAs). The highly polar and acidic nature of VCAs significantly limits the number of currently available GC stationary phases, which are all largely based on acid-modified polyethylene glycol. In this study, it is shown that this class of ZILs exhibit strong retention of VCAs with excellent peak symmetry. Unique chromatog. selectivity toward VCAs is also demonstrated by tuning the structural features of the ZILs. The solvation properties of the three ZILs as well as a structurally similar conventional monocationic IL were characterized using the Abraham solvation parameter model. In the experiment, the researchers used many compounds, for example, 1-Octyl-1H-imidazole (cas: 21252-69-7Safety of 1-Octyl-1H-imidazole).

1-Octyl-1H-imidazole (cas: 21252-69-7) belongs to imidazole derivatives. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs. Imidazole has been usedin the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein, in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography, as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells.Safety of 1-Octyl-1H-imidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Formation constants of metal complexes of substituted benzimidazoles with different bivalent metal ions was written by Murthy, A. Krishna;Lingaiah, P.. And the article was included in Indian Journal of Chemistry, Section A: Inorganic, Physical, Theoretical & Analytical in 1984.COA of Formula: C8H8N2 This article mentions the following:

The formation constants of the complexes of 4 (or 7)-methylbenzimidazole, 2-(2′-hydroxyphenyl)benzimidazole, 2-(2′-hydroxy-5′-bromophenyl)benzimidazoles, 2-(2′-hydroxy-3′-methoxy)benzimidazole, 2-(1′-hydroxyethyl)benzimidazole with Mn(II), Co(II), Ni(II), Cu(II), Zn(II), and Cd(II) were determined pH-metrically at different ionic strengths, temperatures, and in solutions of varying dielec. constant The results show that the metal ion reacts with the neutral ligand in the 1st stage and with the anionic ligand in the second stage. In the experiment, the researchers used many compounds, for example, 7-Methyl-1H-benzo[d]imidazole (cas: 4887-83-6COA of Formula: C8H8N2).

7-Methyl-1H-benzo[d]imidazole (cas: 4887-83-6) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with a Imidazole is incorporated into many important biological compounds. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Histidine is present in many proteins and enzymes, e.g. by binding metal cofactors, as seen in hemoglobin.COA of Formula: C8H8N2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Effect of 2-alkylbenzimidazoles on the corrosion-electrochemical behavior of iron in hydrochloric acid was written by Makovei, G. L.;Koroleva, V. R.;Kurmakova, I. N.. And the article was included in Zashchita Metallov in 1983.Recommanded Product: 13060-24-7 This article mentions the following:

The effect was studied of benzimidazole (I) [51-17-2] and its 2-alkyl substituted derivatives on the corrosion-electrochem. behavior of Armco Fe in 2N HCl. A test was also made of the correlation between the π-electron d. of these compounds and the following corrosion-electrochem. parameters: corrosion rate, effective activation energy of the corrosion process on an Armco Fe electrode, the slope of the polarization curves, polarization resistance, steady-state potential and screening effect. The distribution of the π-electron d. for I was calculated by the MO LCAO method and is presented in diagrams. In the experiment, the researchers used many compounds, for example, 2-Octylbenzimidazole (cas: 13060-24-7Recommanded Product: 13060-24-7).

2-Octylbenzimidazole (cas: 13060-24-7) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.Recommanded Product: 13060-24-7

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Preparation and In vitro characterization of a novel self-nano emulsifying drug delivery system for a fixed-dose combination of candesartan cilexetil and hydrochlorothiazide was written by Zewail, Moataz B.;El-Gizawy, Sanaa A.;Osman, Mohamed A.;Haggag, Yusuf A.. And the article was included in Journal of Drug Delivery Science and Technology in 2021.Electric Literature of C33H34N6O6 This article mentions the following:

A fixed-dose combination of Candesartan cilexetil (CAN) and Hydrochlorothiazide (HCTZ) is commonly used for the management of hypertension. CAN (BCS class II) and HCTZ (BCS class IV) suffer from inadequate oral bioavailability. Herein, the study aims to design a self-nano emulsifying drug delivery system (SNEDDS) containing a fixed-dose combination of both drugs to enhance their dissolution rate and hence oral bioavailability. Formulation of fixed-dose combination-loaded SNEDDS was carried out using various oils, surfactants, and co-surfactants, and phase diagrams were plotted using different ratios. In vitro characterizations of drug-loaded SNEDDS were achieved through optical clarity, emulsification efficiency, globule size, morphol., viscosity, drug-excipient interactions, and thermodn. stability. The in vitro release profiles of both drugs from optimized SNEDDS and their in vivo biol. activity compared to free drugs and a marketed product were studied. Optimized formulas showed a percentage transmittance greater than 90%, emulsification time less than 1 min, globule size in the nanometric range of (27-69 nm), and superior thermodn. stability after dilution and at different pH values. Fourier Transform Infra-Red (FTIR) studies demonstrated the absence of physicochem. interactions between drugs and additives. Transmission electron microscopy (TEM) images revealed spherical, non-aggregated globules that were consistent with the results of size anal. Optimized SNEDDS showed a better release profile for both drugs than those of pure drugs and marketed products and therefore, higher biol. activity was observed in hypertensive rats. SNEDDS can be used as a promising drug delivery carrier for improvement of the dissolution rate and the pharmacodynamic activity of the antihypertensive fixed-dose combination of CAN/HCTZ. In the experiment, the researchers used many compounds, for example, 1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate (cas: 145040-37-5Electric Literature of C33H34N6O6).

1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate (cas: 145040-37-5) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with a Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).Electric Literature of C33H34N6O6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Muco-adhesive buccal tablets of candesartan cilexetil for oral delivery: preparation, in-vitro and ex-vivo evaluation was written by Samanthula, Kumara Swamy;Bairi, Agaiah Goud;Mahendra, Kumar C. B.. And the article was included in Journal of Drug Delivery and Therapeutics in 2021.HPLC of Formula: 145040-37-5 This article mentions the following:

Candesartan cilexetil (CC) is an angiotensin II-receptor blocker (ARB). The antihypertensive effect of CC 4-16 mg/day was as great as that of other once-daily dosage regimens. Candesartan cilexetil has high first-pass metabolism and low oral bioavailability. The bioavailability of such drugs may be significantly improved if delivered through the buccal route; hence mucosal delivery is one of the alternative methods of systemic drug delivery. This study’s objective was to develop mucoadhesive buccal tablets of candesartan cilexetil using carbopol-934P, hydroxyl Pr Me cellulose (HPMC), Eudragit RLPO, and sodium carboxy Me cellulose (Na-CMC) as mucoadhesive polymers. Prepd CC buccal tablet formulations were evaluated for an optimized system based on physicochem. properties, ex-vivo residence time, in-vitro, and ex vivo permeation studies. The evaluation parameters of the tablets were within the acceptable Pharmacopoeial limits. However, the swelling and bio-adhesive time were increased with increasing polymer concentrations The in-vitro release research shown that buccal tablets with sodium carboxy Me cellulose (Na-CMC) exhibited a higher release than all other formulations and have been considered as optimized CC formulation. The release mechanism from kinetic methods suggests that the drug release follows zero-order kinetics with a diffusion mechanism. Further, in-vivo research in animal fashions is required to prove the bioavailability performance of the formulation. In the experiment, the researchers used many compounds, for example, 1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate (cas: 145040-37-5HPLC of Formula: 145040-37-5).

1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate (cas: 145040-37-5) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole has been usedin the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein, in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography, as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells.HPLC of Formula: 145040-37-5

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Universal and low energy-demanding platform to produce propylene carbonate from CO₂ using hydrophilic ionic liquids was written by Hernandez, Elisa;Santiago, Ruben;Belinchon, Alejandro;Maria Vaquerizo, Gema;Moya, Cristian;Navarro, Pablo;Palomar, Jose. And the article was included in Separation and Purification Technology in 2022.Related Products of 35487-17-3 This article mentions the following:

Ionic liquids (ILs) have been extensively proposed as efficient catalysts to promote CO₂ cycloaddition reaction to epoxides for producing cyclic carbonates. Recently, liquid-liquid extraction with water as an enhancer approach to regenerate ILs and to purify the product was proposed, since it reduces energy consumption and enhances the neat catalytic activity of the IL due to hydroxyl groups of water. In this work, a comprehensive sample of homogeneous IL catalysts proposed in the literature is exptl. evaluated both in the catalytic step and in its separation by liquid-liquid extraction with water, to demonstrate the universality of the proposed reaction-separation proposal for hydrophilic ILs. Then the complete processes for CO₂ conversion to propylene carbonate were modelled using Aspen Plus to compare the catalyst/product separation efficiency and the specific energy consumption using liquid-liquid extraction and distillation-based platforms. The energy consumption is significantly lower using liquid-liquid platform (1.1-1.3 kWh/kg_PC) than distillation one (2.4-3.1 kWh/kg_PC). It is concluded that hydrophilic ionic liquids, as those formed by [EtOHmim] cation and halide anions, are promising catalysts since they allow: (i) reducing the process energy consumption due to their high catalytic activity and (ii) full catalyst recovering, even at high catalyst loadings, by improving the water extractive properties for IL separation from PC. In the experiment, the researchers used many compounds, for example, 1-Methyl-1H-imidazol-3-ium chloride (cas: 35487-17-3Related Products of 35487-17-3).

1-Methyl-1H-imidazol-3-ium chloride (cas: 35487-17-3) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. Imidazole is incorporated into many important biological compounds. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Histidine is present in many proteins and enzymes, e.g. by binding metal cofactors, as seen in hemoglobin.Related Products of 35487-17-3

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Fermentable sugars by chemical hydrolysis of biomass was written by Binder, Joseph B.;Raines, Ronald T.. And the article was included in Proceedings of the National Academy of Sciences of the United States of America in 2010.Computed Properties of C7H13ClN2 This article mentions the following:

Abundant plant biomass has the potential to become a sustainable source of fuels and chems. Realizing this potential requires the economical conversion of recalcitrant lignocellulose into useful intermediates, such as sugars. We report a high-yielding chem. process for the hydrolysis of biomass into monosaccharides. Adding water gradually to a chloride ionic liquid-containing catalytic acid leads to a nearly 90% yield of glucose from cellulose and 70-80% yield of sugars from untreated corn stover. Ion-exclusion chromatog. allows recovery of the ionic liquid and delivers sugar feedstocks that support the vigorous growth of ethanologenic microbes. This simple chem. process, which requires neither an edible plant nor a cellulase, could enable crude biomass to be the sole source of carbon for a scalable biorefinery. In the experiment, the researchers used many compounds, for example, 1-ethyl-2,3-dimethylimidazolium chloride (cas: 92507-97-6Computed Properties of C7H13ClN2).

1-ethyl-2,3-dimethylimidazolium chloride (cas: 92507-97-6) belongs to imidazole derivatives. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs. Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).Computed Properties of C7H13ClN2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem