Month: December 2022

Tewari, S. N. published the artcileDetection and determination of psychotropic drugs by thin layer chromatography and its application in toxicological analysis, Related Products of imidazoles-derivatives, the publication is Zentralblatt fuer Pharmazie, Pharmakotherapie und Laboratoriumsdiagnostik (1977), 116(11), 1123-9, database is CAplus.

The detection, identification, and determination of 22 tranquilizers in tissues by thin-layer chromatog. using 18 solvent systems and 6 chromogenic reagents is described. The tissues were homogenized, incubated at 100° in concentrated HCl and ether extracted through an acid-base cycle. Tissue distributions of promazine [58-40-2], chlorpromazine [50-53-3], thioridazine [50-52-2], and imipramine [50-49-7] in cases of human poisoning were determined using 2 solvent systems and chromogenic reagents.

Zentralblatt fuer Pharmazie, Pharmakotherapie und Laboratoriumsdiagnostik published new progress about 2508-72-7. 2508-72-7 belongs to imidazoles-derivatives, auxiliary class Inhibitor,Immunology/Inflammation,Histamine Receptor, name is N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride, and the molecular formula is C12H23N3S, Related Products of imidazoles-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Stawowczyk, Adolf published the artcileTriethanolamine stearate compatibility with some drugs in emulsion ointments, Recommanded Product: N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride, the publication is Farmacja Polska (1975), 31(2), 105-9, database is CAplus.

Benzalkanium bromide and Vioform [130-26-7] were the only 2 of the 12 drugs tested which were stable for the whole duration of the exptl. period in the presence of triethanolamine stearate [4568-28-9] in solutions and emulsion ointments. Sulfathiazole [72-14-0] was stable for 30 days in solutions, but became discolored within 20 days in ointment. Ointments of ethacridine lactate [1837-57-6] were stable for at least 6 months, and those of diphenhydramine-HCl [147-24-0], chloropyribenzamine-HCl [6170-42-9], and tripellennamine-HCl [154-69-8] for 30 days.

Farmacja Polska published new progress about 2508-72-7. 2508-72-7 belongs to imidazoles-derivatives, auxiliary class Inhibitor,Immunology/Inflammation,Histamine Receptor, name is N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride, and the molecular formula is C3H3Br2ClO, Recommanded Product: N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Popov, I. I. published the artcileReaction of 2-(chloromethyl)benzimidazoles with acetylacetone and benzoylacetone. Acidic cleavage of substituted β-diketones, Recommanded Product: 2-(Chloromethyl)-1-methyl-1H-benzo[d]imidazole, the publication is Khimiya Geterotsiklicheskikh Soedinenii (1996), 1067-1071, database is CAplus.

The title reactions gave benzimidazolyl ketones I (R = R¹ = Me; R = Ph, R¹ = H, Me). When 2-(chloromethyl)benzimidazole reacted with acetylacetone, the product was the pyrrolobenzimidazole II.

Khimiya Geterotsiklicheskikh Soedinenii published new progress about 4760-35-4. 4760-35-4 belongs to imidazoles-derivatives, auxiliary class Chloride,Benzimidazole, name is 2-(Chloromethyl)-1-methyl-1H-benzo[d]imidazole, and the molecular formula is C9H9ClN2, Recommanded Product: 2-(Chloromethyl)-1-methyl-1H-benzo[d]imidazole.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Popov, I. I. published the artcile(1-Methylbenzimidazo-2-yl)carbene. Reaction of 1-methyl-2-(chloromethyl)benzimidazole with nucleophiles, Computed Properties of 4760-35-4, the publication is Khimiya Geterotsiklicheskikh Soedinenii (1989), 1422, database is CAplus.

Treating 2-(chloromethyl)-1-methylbenzimidazole (I) with aqueous NH₃ in the presence of 40% aqueous NaOH gave 2-(aminomethyl)-1-methylbenzimidazole. Under phase-transfer catalyzed conditions (50% NaOH, Et₃(PhCH₂)N⁺Cl^–) in Me₂CO or DMSO pyrazinobisbenzimidazole II was formed, but in DMF or EtOH 2-(dimethylamino)- and 2-ethoxy-1-methylbenzimidazoles were obtained, resp.

Khimiya Geterotsiklicheskikh Soedinenii published new progress about 4760-35-4. 4760-35-4 belongs to imidazoles-derivatives, auxiliary class Chloride,Benzimidazole, name is 2-(Chloromethyl)-1-methyl-1H-benzo[d]imidazole, and the molecular formula is C9H9ClN2, Computed Properties of 4760-35-4.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Popov, I. I. published the artcileTransformations of 2-(α-chloroalkyl)benzimidazoles, Recommanded Product: 2-(Chloromethyl)-1-methyl-1H-benzo[d]imidazole, the publication is Khimiya Geterotsiklicheskikh Soedinenii (1993), 664-72, database is CAplus.

Phase-transfer dehydrochlorination/cyclodimerization of title compounds I (X = Cl: R = H, Me) in water-DMSO system afforded pyrazinobis(benzimidazole)s II in 96 and 93% yields, resp. II (R = Me) was similarly obtained (in 76% yield) via dehydration/cyclodimerization of I (X = OH, R = Me) in polyphosphoric or sulfuric acid; I (X = OH, R = H) was inert under the reaction conditions. II (R = H) was obtained in 90% yield via diazotization of I (X = NH₂, R = H). Phase-transfer dehydrochlorination of (chloromethyl)benzimidazole III using DMF or EtOH afforded the corresponding carbene-derived products IV (R¹ = NMe₂, OEt, resp.). Phase-transfer dehydrochlorination of (chloromethyl)benzimidazoles (using DMSO) in presence of β-diketones MeCOCH₂COR (R = Me, Ph) afforded pyrrolobenzimidazoles V (R¹ = H, Me).

Khimiya Geterotsiklicheskikh Soedinenii published new progress about 4760-35-4. 4760-35-4 belongs to imidazoles-derivatives, auxiliary class Chloride,Benzimidazole, name is 2-(Chloromethyl)-1-methyl-1H-benzo[d]imidazole, and the molecular formula is C9H9ClN2, Recommanded Product: 2-(Chloromethyl)-1-methyl-1H-benzo[d]imidazole.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Ott, Ingo published the artcileMetal N-heterocyclic carbene complexes in medicinal chemistry, Recommanded Product: 1,3-Bis(2,6-diisopropylphenyl)-4,5-dihydro-1H-imidazol-3-ium chloride, the publication is Advances in Inorganic Chemistry (2020), 121-148, database is CAplus.

A review. Based on their strong s-donor properties N-heterocyclic carbene (NHC) ligands can form stable complexes with many transition metals. Numerous applications of metal NHC complexes have been developed in the field of chem. catalysis. The option to generate very stable complexes as well as the convenient access to a high number of structurally diverse NHC ligands have made them also attractive target compounds in inorganic medicinal chem. A fast increasing number of reports demonstrates that metal NHC complexes provide an excellent scaffold for metallodrug design and many examples have been studied pharmacol. in great detail. This chapter focuses on metal NHC complexes containing the selected metals ruthenium, rhodium, silver, iridium and gold.

Advances in Inorganic Chemistry published new progress about 258278-25-0. 258278-25-0 belongs to imidazoles-derivatives, auxiliary class Achiral NHCs Ligands, name is 1,3-Bis(2,6-diisopropylphenyl)-4,5-dihydro-1H-imidazol-3-ium chloride, and the molecular formula is C27H39ClN2, Recommanded Product: 1,3-Bis(2,6-diisopropylphenyl)-4,5-dihydro-1H-imidazol-3-ium chloride.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Omar, Nabil M. published the artcileImproved spectrophotometric determination of antazoline, Recommanded Product: N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride, the publication is Journal of Pharmaceutical Sciences (1978), 67(11), 1610-13, database is CAplus and MEDLINE.

A simple, precise, and accurate spectrophotometric determination of antazoline (I) salts was developed by improving the ceric sulfate procedure. Replacement of water with HOAc for the preparation of all assay solutions permitted reproducible measurements of the chromogen that absorbed at 505 nm. An appreciable increase in color stability was attained by the controlled addition of HClO₄ to the ceric reagent prior to interaction with I at room temperature Evidence is provided to account for the oxidation of I at the expense of a complex ceric species. Other 2-imidazolines or phenylephrine did not interfere with the investigated color reaction. In addition to the high value of the chromogen molar absorptivity, ideal adherence of color absorption to Beer’s law permitted accurate and reproducible estimation of I over the 1-10-μg range. The procedure was applied to the anal. of different I dosage forms.

Journal of Pharmaceutical Sciences published new progress about 2508-72-7. 2508-72-7 belongs to imidazoles-derivatives, auxiliary class Inhibitor,Immunology/Inflammation,Histamine Receptor, name is N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride, and the molecular formula is C17H20ClN3, Recommanded Product: N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Majdan-Cegincara, Roghayeh published the artcileEffect of 1-Butyl-1-methylpyrrolidinium trifluoromethanesulfonate on water activity of ternary aqueous ionic liquid solutions containing [BMIm]Br, [BMIm]Cl, [HMIm]Br, and [HMIm]Cl, at 298.15 K, HPLC of Formula: 79917-90-1, the publication is Journal of Chemical Thermodynamics (2022), 106858, database is CAplus.

In improved isopiestic method, the effect of 1-Bu 1-methylpyrrolidinium trifluoromethanesulfonate ([BMP][TfO]) on the activity of water of aqueous solutions of 1-Bu 3-Me imidazolium bromide ([BMIm]Br), 1-Bu 3-Me imidazolium chloride ([BMIm]Cl), 1-hexyl 3-Me imidazolium bromide ([HMIm]Br), and 1-hexyl 3-Me imidazolium chloride ([HMIm]Cl) was determined Some quantities of vapor liquid equilibrium were calculated from the exptl. values. The activity coefficients of [BMIm]Br, [BMIm]Cl, [HMIm]Br, and [HMIm]Cl in binary and ternary systems were calculated by the results obtained from correlating the activity of water measured in these systems with TNRF-mNRTL local composition based model. Through it, the transfer of these ionic liquids from water to aqueous ternary solutions containing [BMP][TfO] was investigated with respect to the transfer Gibbs energy. The interactions between solute and solvent were highlighted using the transfer Gibbs energy, water activity and partial pressure of water data.

Journal of Chemical Thermodynamics published new progress about 79917-90-1. 79917-90-1 belongs to imidazoles-derivatives, auxiliary class Ionic Liquid,Ionic Liquid, name is 3-Butyl-1-methyl-1H-imidazol-3-ium chloride, and the molecular formula is C8H15ClN2, HPLC of Formula: 79917-90-1.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Jang, Kwang-Suk published the artcileBiolabeling and binding evaluation of amphiphilic nanocrystallopolymers, Safety of N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide, the publication is Journal of Nanomaterials (2016), 7416532/1-7416532/7, database is CAplus.

Surfactant-like inorganic-organic hybrid mols. named as nanocrystallopolymers were designed by conjugation of the hydrophilic synthetic poly(amino acid), poly-α,β-(N-(2-hydroxyethyl)l-aspartamide), with hydrophobic inorganic nanoparticles. In aqueous media, amphiphilic nanocrystallopolymers form self-aggregates with unique morphologies. Here, a simple biolabeling method of nanocrystallopolymers was developed. Biotin was selected as a model biomol. The specific binding of biotin-labeled nanocrystallopolymers to the targeted surface was evaluated with a surface plasmon resonance sensor.

Journal of Nanomaterials published new progress about 359860-27-8. 359860-27-8 belongs to imidazoles-derivatives, auxiliary class Other Aliphatic Heterocyclic,Chiral,Amine,Amide,Ether,Inhibitor, name is N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide, and the molecular formula is C18H34N4O5S, Safety of N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Ismaiel, Saad A. published the artcileVolumetric determination of antazoline, diphenhydramine, and ephedrine in some pharmaceutical preparations, Safety of N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride, the publication is Pharmazie (1975), 30(1), 58, database is CAplus and MEDLINE.

Antazoline-HCl (I) [2508-72-7] or diphenhydramine-HCl (II) [147-24-0] can be determined in the presence of ephedrine-HCl (III) [50-98-6] by a modification of the nonaqueous titrimetric method of BP 1973, i.e., by the prior addition of pure NaHCO3 and cooling to <15° (to prevent decomposition of NaHCO3 → Na2CO3), extraction of the liberated I and(or) II with CHCl3, the addition of NaOH to the separated aqueous layer and extraction of the liberated III with CHCl3. The CHCl3 solutions were evaporated and the residues titrated with HClO4 (crystal violet, indicator). The method compares favorably with that of Ismaiel (ibid. 1974).

Pharmazie published new progress about 2508-72-7. 2508-72-7 belongs to imidazoles-derivatives, auxiliary class Inhibitor,Immunology/Inflammation,Histamine Receptor, name is N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride, and the molecular formula is C17H20ClN3, Safety of N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem