Month: December 2022

Guedes, Maria Fernanda published the artcileEffectiveness of preservatives in multidose ocular and nasal formulations. II. Contamination of nasal products, COA of Formula: C17H20ClN3, the publication is Revista Portuguesa de Farmacia (1986), 36(1), 29-33, database is CAplus.

In sulfacetamide  [144-80-9] nasal solutions, chlorobutanol  [57-15-8] was ineffective with the solution turning brown-yellow possibly due to absorption of chlorobutanol by the plastic dropper and oxidation Chlorocresol  [1321-10-4] was more effective in the formulations. The permeability of polyethylene  [9002-88-4] to water, steam, and gases was also studied.

Revista Portuguesa de Farmacia published new progress about 2508-72-7. 2508-72-7 belongs to imidazoles-derivatives, auxiliary class Inhibitor,Immunology/Inflammation,Histamine Receptor, name is N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride, and the molecular formula is C17H20ClN3, COA of Formula: C17H20ClN3.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Garcia-Dominguez, Patricia published the artcileSynthesis of L-Au(I)-CF₂H Complexes and Their Application as Transmetalation Shuttles to the Difluoromethylation of Aryl Iodides, SDS of cas: 258278-25-0, the publication is Organometallics (2021), 40(17), 2923-2928, database is CAplus.

We describe herein two alternative protocols to efficiently prepare difluoromethylgold(I) complexes bearing ancillary ligands with different electronic and steric properties. LAu-OX (X = H and t-Bu) species, formed in the presence of base, have been identified as intermediate complexes involved in these transformations. The application of these compounds as “CF₂H transmetalation shuttles” from gold to palladium has been demonstrated in a Pd-catalyzed difluoromethylation reaction of aryl iodides, in which the Au-to-Pd transfer of “CF₂H” is feasible under stoichiometric conditions. These findings will pave the way for catalytic manifolds in gold chem.

Organometallics published new progress about 258278-25-0. 258278-25-0 belongs to imidazoles-derivatives, auxiliary class Achiral NHCs Ligands, name is 1,3-Bis(2,6-diisopropylphenyl)-4,5-dihydro-1H-imidazol-3-ium chloride, and the molecular formula is C27H39ClN2, SDS of cas: 258278-25-0.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Garcia Rodriguez, Miguel published the artcileAction of iproniazid and some antihistamines on the adrenergic neuron blockade produced by bretylium, HPLC of Formula: 2508-72-7, the publication is Revista Cubana de Farmacia (1974), 8(2), 183-5, database is CAplus.

Systral (chlorphenoxamine-HCl)(I) [562-09-4], gravinol (dimenhydrinate) [523-87-5], suprastin (chloropyramine) [59-32-5], and antistina (antazoline-HCl) [2508-72-7] (each at 15 μg/ml for 15 min) blocked the bretylium [59-41-6]-induced sympatholytic activity in isolated rat vas deferens, whereas iproniazid-HCl [6011-62-7] had no effect. Patients under prolonged treatment with antihistamines who show signs and symptoms of hypertension probably should not be subjected to simultaneous treatment with adrenergic blocking agents.

Revista Cubana de Farmacia published new progress about 2508-72-7. 2508-72-7 belongs to imidazoles-derivatives, auxiliary class Inhibitor,Immunology/Inflammation,Histamine Receptor, name is N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride, and the molecular formula is C17H20ClN3, HPLC of Formula: 2508-72-7.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Gan, Haifeng published the artcileFe/S-Catalyzed Redox Condensation of o-Nitrophenols/thiophenols/anilines with Dibenzyl Disulfide: Access to 2-Arylbenzazoles, Quality Control of 2622-67-5, the publication is ChemistrySelect (2020), 5(2), 717-721, database is CAplus.

An Fe/S-catalyzed approach to 2-arylbenzazoles I (R¹ = H, 4-CH₃, 4-OCH₃, 4-F, 4-Cl, 4-C(CH₃)₃; R² = 5-CH₃, 6-Br, 5-C(O)₂CH₃, etc.; X = O, NH, NCH₃, NC₆H₅, NCH₂C₆H₅, S) and 2-phenyloxazolo[4,5-c]pyridine from dibenzyl disulfides (R¹C₆H₄CH₂S)₂ and o-nitrophenols 2-NO₂R²C₆H₃OH/thiophenols R¹C₆H₄CH₂SH/anilines 2-NO₂R²C₆H₃NHR³ (R³ = H, Me, Ph, Bn) in the presence of base NMP has been developed. The reactions proceeded in moderate to excellent yields with good functional tolerance and gram-scale application. Mechanistic research indicated that Fe/S clusters play an important role in the formation of products and DMSO is also important to oxidize benzyl mercaptans to give dibenzyl disulfides.

ChemistrySelect published new progress about 2622-67-5. 2622-67-5 belongs to imidazoles-derivatives, auxiliary class Benzimidazole,Benzene,Benzimidazole, name is 1,2-Diphenyl-1H-benzo[d]imidazole, and the molecular formula is C19H14N2, Quality Control of 2622-67-5.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Dutt, Manesh Chandra published the artcileGas chromatographic identification of common drugs by their multiple peaks and those of their trimethylsilyl derivatives, Safety of N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride, the publication is Journal of Chromatography (1982), 248(1), 115-24, database is CAplus.

The extent to which common drugs produce multiple peaks in gas chromatog. on an OV-17 column at an injection port temperature of 300° and temperature programming from 120 to 270° or at an isothermal temperature of 300° was studied. Of the 116 drugs tested, 46 produced >1 peak either as the parent compound or as the trimethylsilyl derivative Retention times provide a useful means of identification.

Journal of Chromatography published new progress about 2508-72-7. 2508-72-7 belongs to imidazoles-derivatives, auxiliary class Inhibitor,Immunology/Inflammation,Histamine Receptor, name is N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride, and the molecular formula is C17H20ClN3, Safety of N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Anonymous published the artcilePreparation of 5-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole zinc salt, Related Products of imidazoles-derivatives, the publication is Research Disclosure (2002), 462(Oct.), P1835, database is CAplus.

A method for the preparing the Zn salt of (S)-5-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole is described. The compound was prepared by dissolving 0.185 g of 1.36 mmol Zn chloride in a 25 mL of H₂O. The formed solution is then added dropwise to 50mL aqueous solution of 1g, 2.7 mmol 5-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole Na salt while stirring at room temperature The mixture is stirred for an hour and the resulting precipitate is filtered off. The filter cake was washed with a mixture of ether and 25mL acetone. The product is then suspended in an EtOH and thereafter dried at reduced pressure. A 0.70 g of the Zn salt can be obtained with a Zn content of 8.8%.

Research Disclosure published new progress about 161796-78-7. 161796-78-7 belongs to imidazoles-derivatives, auxiliary class Membrane Transporter/Ion Channel,Proton Pump, name is Sodium (S)-6-methoxy-2-(((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide, and the molecular formula is C17H18N3NaO3S, Related Products of imidazoles-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Anonymous published the artcileReasoned opinion on the review of the existing maximum residue levels (MRLs) for cyazofamid according to Article 12 of Regulation (EC) No 396/2005, Safety of 4-Chloro-5-(p-tolyl)-1H-imidazole-2-carbonitrile, the publication is EFSA Journal (2012), 10(12), 3065, 38 pp., database is CAplus.

According to Article 12 of Regulation (EC) No 396/2005, the European Food Safety Authority (EFSA) has reviewed the Maximum Residue Levels (MRLs) currently established at European level for the pesticide cyazofamid. In order to assess the occurrence of cyazofamid residues in plants, processed commodities, rotational crops and livestock, EFSA considered the conclusions derived in the framework of Directive 91/414/EEC as well as the European authorisations reported by Member States (incl. the supporting residues data). Based on the assessment of the available data, MRL proposals were derived and a consumer risk assessment was carried out. Although no apparent risk to consumers was identified, some information required by the regulatory framework was found to be missing. Hence, the consumer risk assessment is considered indicative only and some MRL proposals derived by EFSA still require further consideration by risk managers.

EFSA Journal published new progress about 120118-14-1. 120118-14-1 belongs to imidazoles-derivatives, auxiliary class Imidazole,Chloride,Nitrile,Benzene, name is 4-Chloro-5-(p-tolyl)-1H-imidazole-2-carbonitrile, and the molecular formula is C11H8ClN3, Safety of 4-Chloro-5-(p-tolyl)-1H-imidazole-2-carbonitrile.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Acree, William E. published the artcileComment on “Determination and Thermodynamic Modeling of Solid-Liquid Phase Equilibrium for Esomeprazole Sodium in Monosolvents and in the (Ethanol + Ethyl Acetate) Binary Solvent Mixtures”, Computed Properties of 161796-78-7, the publication is Journal of Chemical & Engineering Data (2018), 63(3), 855-856, database is CAplus.

Errors are found in several of the math. representations in the published paper by Zhao and co-workers. Published curve-fit parameters for several of the modified Apelblat model representations yield back-calculated mole fraction solubilities of esomeprazole sodium that exceed unity. Mole fraction concentrations cannot exceed unity. Back-calculated mole fraction solubilities for a math. representation, presumably based on the Jouyban-Acree model, were also found to exceed unity.

Journal of Chemical & Engineering Data published new progress about 161796-78-7. 161796-78-7 belongs to imidazoles-derivatives, auxiliary class Membrane Transporter/Ion Channel,Proton Pump, name is Sodium (S)-6-methoxy-2-(((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide, and the molecular formula is C17H18N3NaO3S, Computed Properties of 161796-78-7.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Domanski, Michal published the artcileTunable Microwave Flow System for Scalable Synthesis of Alkyl Imidazolium-type Ionic Liquids, HPLC of Formula: 79917-90-1, the publication is Organic Process Research & Development (2022), 26(8), 2498-2509, database is CAplus.

A continuous flow auto-frequency tuning single-mode microwave reactor is disclosed as a powerful platform to synthesize alkyl imidazolium salts, e.g., I and II, as ionic liquids/ionic liquid precursors in up to near-quant. yields, 100-600 g h^-1 productivities with record space-time yields. Challenges faced, including viscosity changes, dielec. property changes, and phase separation, were addressed by different operation modes of the reactor without reactor redesigning. Depending on the purpose, this highly productive method could prove to be useful for intensive applications of ionic liquids

Organic Process Research & Development published new progress about 79917-90-1. 79917-90-1 belongs to imidazoles-derivatives, auxiliary class Ionic Liquid,Ionic Liquid, name is 3-Butyl-1-methyl-1H-imidazol-3-ium chloride, and the molecular formula is C8H15ClN2, HPLC of Formula: 79917-90-1.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Ren, Wei published the artcilePalladium-NHC-Catalyzed Allylic Alkylation of Pronucleophiles with Alkynes, COA of Formula: C27H39ClN2, the publication is Organic Letters (2019), 21(19), 7956-7960, database is CAplus and MEDLINE.

The palladium-N-heterocyclic carbene (NHC)-catalyzed allylic alkylation of various pronucleophiles with alkynes has been accomplished under mild conditions. The protocol exhibits broad functional group compatibility and high atom economy. Moreover, the catalytic process avoids the use of external oxidants and acid as additives.

Organic Letters published new progress about 258278-25-0. 258278-25-0 belongs to imidazoles-derivatives, auxiliary class Achiral NHCs Ligands, name is 1,3-Bis(2,6-diisopropylphenyl)-4,5-dihydro-1H-imidazol-3-ium chloride, and the molecular formula is C27H39ClN2, COA of Formula: C27H39ClN2.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem