Month: December 2022

Li, Ting-ting published the artcileRP-HPLC determination of related substances of esomeprazole sodium, Formula: C17H18N3NaO3S, the publication is Yaowu Fenxi Zazhi (2013), 33(4), 656-660, database is CAplus.

A reversed-phase high-performance liquid chromatog. (RP-HPLC) method was established for the determination of related substances of esomeprazole sodium. The determination was performed on a Venusil XBP C₁₈ (L) column (250 mm × 4.6 mm, 5 μm), with a mobile phase consisting of a mixture of acetonitrile and phosphate buffer (pH 7.6) by gradient elution. The column temperature was set at 30°C with a flow rate of 0.8 mL·min^-1, and the detective wavelength was 302 nm. The related substances were completely separated from the main constituent. The calibration curves for 5-methoxy-2-mercaptobenzimidazole, omeprazole sulfone N-oxide, omeprazole sulfone, esomeprazole sodium and omeprazole sulfide revealed good linearities over the ranges of 3.99-29.94 μg·mL^-1 (r=0.9998), 4.06-30.45 μg·mL^-1 (r=0.9999), 2.46-18.42 μg·mL^-1 (r=0.9998), 3.96-29.67 μg·mL^-1 (r=0.9994), and 4.08-31.32 μg·mL^-1 (r=0.9998), resp. The recoveries of the above compounds were 99.5% with RSD of 0.6%, 99.1% with RSD of 0.3%, 99.0% with RSD of 0.6%, 99.2% with RSD of 0.9%, and 99.0% with RSD of 0.7%, resp. The method could be used for testing the product quality of esomeprazole sodium.

Yaowu Fenxi Zazhi published new progress about 161796-78-7. 161796-78-7 belongs to imidazoles-derivatives, auxiliary class Membrane Transporter/Ion Channel,Proton Pump, name is Sodium (S)-6-methoxy-2-(((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide, and the molecular formula is C17H18N3NaO3S, Formula: C17H18N3NaO3S.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Ma, Yingchong published the artcileRheological Characterization of Mixed Aqueous Solutions of Enzymatic Hydrolysis Lignin and Ionic Liquid, Quality Control of 79917-90-1, the publication is ChemistrySelect (2022), 7(21), e202200020, database is CAplus.

Here we present a rheol. study of enzymic hydrolysis lignin (EH lignin) in 1-butyl-3-methylimidazolium chloride ([C₄min]Cl) aqueous solutions The effects of ionic liquid mass fraction, shear rate and temperature on the viscosity and macromol. chain configuration of EH lignin / [C₄min] Cl aqueous solution were studied. The results showed that the viscosity of the aqueous solutions increased with the increase of lignin content. The mass percentages of overlapping and winding, responding to divisions of lignin macromols. existence state, were varied with changing in the temperature and mass percentages of ionic liquid Increasing the mass of ionic liquid will significantly change the viscosity of lignin solution Most of the lignin solutions had shear thinning behavior, suggesting that macromol. chains of lignin moved with orientation to the fluid, and disentangled under the shear force. The viscosity of lignin solution decreased with the increase of temperature, and the viscosity activation energy increased with the increase of lignin or ionic liquid mass fraction.

ChemistrySelect published new progress about 79917-90-1. 79917-90-1 belongs to imidazoles-derivatives, auxiliary class Ionic Liquid,Ionic Liquid, name is 3-Butyl-1-methyl-1H-imidazol-3-ium chloride, and the molecular formula is C8H15ClN2, Quality Control of 79917-90-1.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Han, Wei published the artcileDetermination of residual solvents in esomeprazole sodium by headspace gas chromatography, Formula: C17H18N3NaO3S, the publication is Shenyang Yaoke Daxue Xuebao (2012), 29(4), 276-279, database is CAplus.

A method for determination of seven kinds of residual solvents in esomeprazole sodium by headspace gas chromatog. was developed. The residual solvents were separated on DB-624 (30 m × 530 μm, 3 μm) capillary chromatog. column using temperature programming. Nitrogen gas was used as carrier gas with FID as detector. There was a good linear relationship in the exptl. concentrations of ethanol, acetone, isopropanol, acetonitrile, dichloromethane, Me tert-Bu ether, toluene (r≳0.9990). The average recoveries were ranged from 89.7% to 104.6%. The limit of detection were 1.40, 0.39, 1.60, 1.10, 0.74, 0.04 and 0.16 mg·L^-1, resp. The method was sensitive, accurate and reproducible. It could be used for the detection of residual solvents in esomeprazole sodium.

Shenyang Yaoke Daxue Xuebao published new progress about 161796-78-7. 161796-78-7 belongs to imidazoles-derivatives, auxiliary class Membrane Transporter/Ion Channel,Proton Pump, name is Sodium (S)-6-methoxy-2-(((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide, and the molecular formula is C17H18N3NaO3S, Formula: C17H18N3NaO3S.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Cao, Mengyan published the artcileIonic Liquid-Assisted Fast Synthesis of Carbon Dots with Strong Fluorescence and Their Tunable Multicolor Emission, Synthetic Route of 79917-90-1, the publication is Small (2022), 18(11), 2106683, database is CAplus and MEDLINE.

Conventional synthesis of carbon dots (CDs) mostly involves a hydrothermal or solvent-thermal reaction which needs relatively high temperature and pressure. In this work, ionic liquid is used to assist in fast synthesizing CDs with an ultrahigh photoluminescent quantum yield (98.5%) by heating at a low temperature (≤100°C) and at atm. pressure. In addition, through this approach, tunable multicolor emissive CDs can be successfully achieved and used for preparing high-performance white light-emitting diodes. Theor. computation proves that the activity of synthesis reaction can be significantly enhanced by ionic liquids D. functional theory calculation reveals that the size and graphite nitrogen ratios of CDs have an effect on bandgap reduction, resulting in a red shift of the emission, which is in good agreement with the exptl. results. This simple and promising approach for fast synthesis of tunable emissive CDs using ionic liquid affords the facilitation of CDs-based luminescent materials for fast manufacturing of functional devices.

Small published new progress about 79917-90-1. 79917-90-1 belongs to imidazoles-derivatives, auxiliary class Ionic Liquid,Ionic Liquid, name is 3-Butyl-1-methyl-1H-imidazol-3-ium chloride, and the molecular formula is C8H15ClN2, Synthetic Route of 79917-90-1.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Cao, Mengyan published the artcileRapid and Large-Scale Preparation of Stable and Efficient White Light Emissive Perovskite Microcrystals Using Ionic Liquids, Related Products of imidazoles-derivatives, the publication is Journal of Physical Chemistry Letters (2022), 13(26), 6048-6056, database is CAplus and MEDLINE.

In this work, we report large-scale preparation of stable Sb³⁺ and Bi³⁺ codoped Cs₂ZrCl₆ microcrystals for highly efficient white light emission using ionic liquids, demonstrating a broad dual-band white emission covering 400-800 nm. The dual emissions originate from the associated self-trapped excitons of the [SbCl₆]^3- and [BiCl₆]^3- octahedra. Moreover, the ratio of the dual-emission peaks can be effectively regulated by tuning the excitation wavelength. Meanwh000.0.0.0.0.ile, to improve the optical properties and stability, ionic liquids are employed to assist the synthesis process of perovskite materials. The white light emission of one of the samples demonstrates CIE coordinates right in the center of the white light region (0.334, 0.331) and an excellent color rendering index (~90.3), accompanied by a 66.1% quantum efficiency. Moreover, our method allows the facile synthesis of large batches of microcrystalline powders. Our findings demonstrate the potential of white phosphors as single components for future applications in lighting fields.

Journal of Physical Chemistry Letters published new progress about 79917-90-1. 79917-90-1 belongs to imidazoles-derivatives, auxiliary class Ionic Liquid,Ionic Liquid, name is 3-Butyl-1-methyl-1H-imidazol-3-ium chloride, and the molecular formula is C8H15ClN2, Related Products of imidazoles-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Jiang, Biao published the artcileCatalytic asymmetric oxidation of heteroaromatic sulfides with tert-butyl hydroperoxide catalyzed by a titanium complex with a new chiral 1,2-diphenylethane-1,2-diol ligand, Formula: C17H18N3NaO3S, the publication is European Journal of Organic Chemistry (2009), 987-991, database is CAplus.

Heteroaromatic sulfoxides, especially 1H-benzimidazolyl pyridinylmethyl sulfoxides, usually used as the blockbuster gastric proton pump inhibitors (PPIs), have been prepared highly enantioselectivity by catalytic asym. oxidation of sulfides attached to nitrogen-containing heterocycles with tert-Bu hydroperoxide in the presence of a chiral titanium complex, formed in situ from Ti(iPrO)₄, chiral 1,2-diphenylethane-1,2-diol and water. The chiral sulfoxides were obtained in high yield (97%) with excellent enantiomeric excess (up to 98%).

European Journal of Organic Chemistry published new progress about 161796-78-7. 161796-78-7 belongs to imidazoles-derivatives, auxiliary class Membrane Transporter/Ion Channel,Proton Pump, name is Sodium (S)-6-methoxy-2-(((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide, and the molecular formula is C17H18N3NaO3S, Formula: C17H18N3NaO3S.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Sun, Xinqi published the artcileDetermination of residual solvents in antazoline hydrochloride, Formula: C17H20ClN3, the publication is Henan Daxue Xuebao, Ziran Kexueban (2009), 39(1), 25-28, database is CAplus.

Capillary gas chromatog. was used to determine residual solventsin antazoline hydrochloride. The linear equation of ethanol is Y = 0.04627 +0.65369X, r = 0.99816 (n = 8), and the range of linearity is 50.35-718.9 g/L and average recovery rate is 98.32% with RSD of 6.79%. The linear equation of toluene is Y = 0.01928 +1.64319X, r = 0.99372 (n = 8), and the range of linearity is 11.6-162.4 g/L and average recovery rate is 98.17% with RSD of 1.5%. The linear equation of DMF is Y = 0.02531 +0.35654X, r = 0.99344 (n = 8), and the range of linearity is 9.8-137.2 g/L and average recovery rate is 98.99% with RSD of 2.34%. Capillary gas chromatog. can be used for determination of antazoline hydrochloride products.

Henan Daxue Xuebao, Ziran Kexueban published new progress about 2508-72-7. 2508-72-7 belongs to imidazoles-derivatives, auxiliary class Inhibitor,Immunology/Inflammation,Histamine Receptor, name is N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride, and the molecular formula is C14H12N2S, Formula: C17H20ClN3.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Hu, Zhiyuan published the artcileI₂-Mediated Intramolecular C-H Amidation for the Synthesis of N-Substituted Benzimidazoles, Application In Synthesis of 2622-67-5, the publication is Journal of Organic Chemistry (2017), 82(6), 3152-3158, database is CAplus and MEDLINE.

A practical intramol. C-H amidation methodol. has been developed using mol. iodine under basic conditions. The required imine substrates were readily obtained by condensation of simple o-phenylenediamine derivatives and aldehydes. The transition-metal-free cyclization reaction described here works well with crude imines and allows for the sequential synthesis of N-protected 2-substituted benzimidazoles without purification of the less stable condensation intermediates. This operationally simple synthetic approach is broadly applicable to a variety of aromatic, aliphatic, and cinnamic aldehydes to produce diverse 1,2-disubstituted benzimidazole derivatives in an efficient and scalable fashion.

Journal of Organic Chemistry published new progress about 2622-67-5. 2622-67-5 belongs to imidazoles-derivatives, auxiliary class Benzimidazole,Benzene,Benzimidazole, name is 1,2-Diphenyl-1H-benzo[d]imidazole, and the molecular formula is C19H14N2, Application In Synthesis of 2622-67-5.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

An, Lianying published the artcileSyntheses of a green organic phosphorescence materials and studies on their photoluminescent properties, Recommanded Product: 1,2-Diphenyl-1H-benzo[d]imidazole, the publication is Advanced Materials Research (Durnten-Zurich, Switzerland) (2012), 455-456(Pt. 2), 880-883, database is CAplus.

By using the N-phenyl-o-nitroaniline and benzoyl chloride as initial raw materials, a green light-emitting material (pbi)₂Ir(acac)₂ (pbiH = 1,2-diphenylbenzimidazole) was produced via a new designed synthesis plan. The structure of the complex was characterized by IR, MS, and DTA. The optical Luminescence Properties of the complex was studied by fluorescence spectrometry anal. The m.p. of the product is 343° which showed that it had thermal stability. The fluorescence spectrometry anal. exptl. results show that the excitation and emission peaks of the organic Ir(III) complex were, resp., 470.6 nm and 526.21 nm which showed that it belongs to green high-brightness light-emitting materials. The oxidation of the intermediate products exposed in air which could cause the quality of product instability was avoided in the new, improved synthesis plan.

Advanced Materials Research (Durnten-Zurich, Switzerland) published new progress about 2622-67-5. 2622-67-5 belongs to imidazoles-derivatives, auxiliary class Benzimidazole,Benzene,Benzimidazole, name is 1,2-Diphenyl-1H-benzo[d]imidazole, and the molecular formula is C19H14N2, Recommanded Product: 1,2-Diphenyl-1H-benzo[d]imidazole.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Shi, Xing-Xing published the artcileFerromagnetic coupling in copper benzimidazole chloride: structural, mass spectrometry, magnetism, and DFT studies, Category: imidazoles-derivatives, the publication is Dalton Transactions (2017), 46(47), 16663-16670, database is CAplus and MEDLINE.

Herein, quasi-square planar Cu^II(Hmbm)Cl₂ (CBC, Hmbm = (1-methyl-1H-benzo[d]imidazol-2-yl)methanol) was arranged in a pseudo orthogonal way to form Cl-bridged chains, and further π···π interactions resulted in distorted hexagonal layers. DFT calculations reveal a bond strength order of Cu-Cl > Cu-O/N ≫ Cu···Cl. ESI-MS data reveal several small fragments from CBC, but oligomeric [Cu^II₂], [Cu^II₃], and [Cu^II₄] for non-zero in-source energies; MS data indicates the occurrence of several chem. processes, viz. splitting of the ligand, oligomerization, and redox reaction of alc. to aldehyde and Cu^II to Cu^I. Gibbs free energies for the fragments were estimated using DFT. The magnetic susceptibility was modeled with the ferromagnetic coupling J(Cu-Cl2a···Cu) = +0.99(30) cm^-1 and J'(π···π) = +0.35(16) cm^-1 and g = 2.38(2). HF-EPR determined the anisotropic g-values, g_x = 2.24, g_y = 2.16, and g_z = 2.09, and a hyperfine constant of A_z = 450 G. DFT calculations from crystal structure data reveal a J(Cu-Cl2a···Cu) of +3.6 at 296 K and +4.1 cm^-1 at 90 K that dominates the magnetic properties, whereas J'(π···π) = 0.04 cm^-1 is negligibly small.

Dalton Transactions published new progress about 7467-35-8. 7467-35-8 belongs to imidazoles-derivatives, auxiliary class Benzimidazole,Alcohol, name is (1-Methyl-1H-benzo[d]imidazol-2-yl)methanol, and the molecular formula is C8H17Br, Category: imidazoles-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem