Month: December 2022

Selective Transport of Cu(II) across a Polymer Inclusion Membrane with 1-Alkylimidazole from Nitrate Solutions was written by Radzyminska-Lenarcik, Elzbieta;Ulewicz, Malgorzata. And the article was included in Separation Science and Technology (Philadelphia, PA, United States) in 2012.Recommanded Product: 21252-69-7 This article mentions the following:

The selective transport of copper(II), zinc(II), cobalt(II), and nickel(II) ions from nitrate solutions across polymer inclusion membranes (PIMs), which consist of cellulose triacetate as polymeric support, o-nitrophenyl pentyl ether as plasticizer, and 1-alkylimidazole (alkyl from hexyl- to decyl) as ion carrier was reported. PIM was characterized by using at. force microscopy (AFM) technique. The results show that Cu(II) can be separated very effectively from other transition metal cations as Zn(II), Co(II), and Ni(II) (at a concentration of 10^-3 mol/dm³ each). Alkyl substituents at position 1 of the imidazole ring have been found to affect the hydrophobic properties and initial flux of the transported metal ions. The efficiency of separation of metal ions by 1-alkylimidazole followed the sequence: Cu(II) > Zn(II) > Co(II) > Ni(II). The highest selectivity coefficient for Cu(II) was found with 1-hexylimidazole and its 1 mol/dm³ solution in PIM. Separation of the ions was more effective for the nitrates(V) than for chlorides. In the experiment, the researchers used many compounds, for example, 1-Octyl-1H-imidazole (cas: 21252-69-7Recommanded Product: 21252-69-7).

1-Octyl-1H-imidazole (cas: 21252-69-7) belongs to imidazole derivatives. Imidazole is the basic core of some natural products such as histidine, purine, histamine and DNA based structures, etc. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has been usedin the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein, in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography, as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells.Recommanded Product: 21252-69-7

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Imidazolium-based ionic liquids with large weakly coordinating anions was written by Levason, William;Pugh, David;Reid, Gillian. And the article was included in New Journal of Chemistry in 2017.Recommanded Product: 1-ethyl-2,3-dimethylimidazolium chloride This article mentions the following:

Eight imidazolium-based salts with the weakly-coordinating anions [BAr^F]^– and [Al(O^tC₄F₉)₄]^– ([BAr^F]^– = tetrakis{3,5-bis(trifluoromethyl)phenyl}borate) have been synthesized. Characterization by ¹H NMR spectroscopy shows that the salts are fully dissociated in solution Six examples have been further characterized by X-ray crystallog., revealing that weak hydrogen bonds do occur in the solid phase between the imidazolium cations and weakly coordinating anions. Comparison with the bulky [IDiPPH] imidazolium cation (IDiPPH = 1,3-bis{2,6-bis(diisopropyl)phenyl}imidazolium) shows that large steric bulk close to the imidazolium protons can preclude hydrogen bonds from forming. Differential scanning calorimetry of the salts reveal that all are thermally stable up to 200 °C which renders them as potentially suitable background electrolytes for electrochem. processes which take place at elevated temperatures In the experiment, the researchers used many compounds, for example, 1-ethyl-2,3-dimethylimidazolium chloride (cas: 92507-97-6Recommanded Product: 1-ethyl-2,3-dimethylimidazolium chloride).

1-ethyl-2,3-dimethylimidazolium chloride (cas: 92507-97-6) belongs to imidazole derivatives. Imidazole is the basic core of some natural products such as histidine, purine, histamine and DNA based structures, etc. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole is incorporated into many important biological compounds. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Histidine is present in many proteins and enzymes, e.g. by binding metal cofactors, as seen in hemoglobin.Recommanded Product: 1-ethyl-2,3-dimethylimidazolium chloride

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Efficient polymeric catalyst for one-pot synthesis of acenaphtho[1,2-b]pyrroles was written by Goldani, Mohammad Taghi;Sandaroos, Reza;Damavandi, Saman. And the article was included in Research on Chemical Intermediates in 2014.Safety of 1-Methyl-3-propylimidazolium Chloride This article mentions the following:

Some new derivatives of acenaphtho[1,2-b]furans have been synthesized efficiently by one-pot reaction of (acenaphthylen-1-yloxy)trimethylsilane, various aldehydes, and isocyanides in the presence of silica-supported ionic liquid In the experiment, the researchers used many compounds, for example, 1-Methyl-3-propylimidazolium Chloride (cas: 79917-89-8Safety of 1-Methyl-3-propylimidazolium Chloride).

1-Methyl-3-propylimidazolium Chloride (cas: 79917-89-8) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).Safety of 1-Methyl-3-propylimidazolium Chloride

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Au/TiO₂ nanotube array based multi-hierarchical architecture for highly efficient dye-sensitized solar cells was written by Fu, Nianqing;Jiang, Xiongzhuo;Chen, Dongchu;Duan, Yandong;Zhang, Guoge;Chang, Menglei;Fang, Yanyan;Lin, Yuan. And the article was included in Journal of Power Sources in 2019.Quality Control of 1-Methylbenzimidazole This article mentions the following:

Control over balanced high light-harvesting and efficient charge transport is of crucial importance for photoelectrochem. applications but still remains great challenge. We develop here single-wall TiO₂ nanotube array with in-situ deposited Au nanoparticles. Based on this Au-TiO₂ hybrid, we further build a cigar-like Au/TiO₂-nanotube-array/TiO₂-nanoparticles multi-hierarchical architecture through a novel vacuum-assisted colloid-filling approach for dye-sensitized solar cell application. In this elaborate structure, Au nanoparticles welding on nanotube walls play dual roles of direct injecting hot electrons into TiO₂ to elevate the conductivity of TiO₂ film by ∼4 times (under illumination) for fast electron transport, and introducing a plasmonic effect to improve light-harvesting as well. Meanwhile, the thick TiO₂ nanoparticle decoration provides the photoanode vast surface area for ∼3.2 times the dye-loading amount of the pristine TiO₂ nanotube array based electrode, which will further boost the light-harvesting remarkably. The resulting dye-sensitized solar cell yields an impressively high power conversion efficiency of 8.93%, which is 190.4% that of the pristine TiO₂ nanotube array based device. This technol. provides also a promising prospect for the preparation of multi-hierarchical structures for a wide range of applications, such as photocatalysis and gas sensors. In the experiment, the researchers used many compounds, for example, 1-Methylbenzimidazole (cas: 1632-83-3Quality Control of 1-Methylbenzimidazole).

1-Methylbenzimidazole (cas: 1632-83-3) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with a Many drugs contain an imidazole ring, such as certain antifungal drugs, the nitroimidazole series of antibiotics, and the sedative midazolam.Quality Control of 1-Methylbenzimidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Interconnection of smectic domains by polyethylene oxide networks for long-range conducting channels towards efficient and thermally stable dye-sensitized solar cells was written by Wang, Caihong;Li, Xueyong;Zhou, Jiwen;Tian, Wen;Ji, Junyi;Tan, Shuai;Wu, Yong. And the article was included in Nanoscale in 2020.Product Details of 1632-83-3 This article mentions the following:

The development of an efficient electrolyte that combines fast charge transport and high stability for advanced energy devices remains a huge challenge because these two qualities are traded off during the normal design process. Nanostructured liquid crystals have shown potential as efficient charge transport media. However, the reported liquid crystal electrolytes showed limited performance in energy devices probably due to the charge transport barrier at the domain interfaces. Herein, a novel approach was proposed to construct self-assembled long-range charge transport channels in liquid crystal electrolytes by interconnecting the liquid crystal domains via flexible polymer networks. A liquid crystal gel electrolyte was prepared by solidifying a smectic electrolyte using polyethylene oxide (PEO) networks, and applied to improve the performance of the dye-sensitized solar cells (DSSCs). In the gel electrolyte, the smectic assembly formed lamellar nanostructures for charge transport at the intra-domains, while the PEO networks aggregated amorphously at the domain interfaces, acting as bridges to interconnect the smectic domains for charge transport over the inter-domains. Based on the coordination of the smectic assembly and PEO aggregation, the charge transport in the liquid crystal gel electrolyte was greatly improved despite a higher viscosity. Conversely, the photovoltaic efficiency of the DSSC prepared from the liquid crystal gel electrolyte was about two times enhanced, with a champion efficiency of 7.2%, compared with that from the smectic electrolyte without PEO. The liquid crystal gel-based DSSC showed superior stable performance within a wide temperature range from 30 to 70°C, and stored after 5000 h. Our work here provides a novel and convenient approach to break the trade-off for high-performance electrolytes towards efficient and stable energy devices. In the experiment, the researchers used many compounds, for example, 1-Methylbenzimidazole (cas: 1632-83-3Product Details of 1632-83-3).

1-Methylbenzimidazole (cas: 1632-83-3) belongs to imidazole derivatives. Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar. Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.Product Details of 1632-83-3

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Chlorodifluoromethane as a C1 Synthon in the Assembly of N-Containing Compounds was written by Ma, Xingxing;Su, Jianke;Zhang, Xingang;Song, Qiuling. And the article was included in iScience in 2019.Recommanded Product: 7-Methyl-1H-benzo[d]imidazole This article mentions the following:

A quadruple cleavage of chlorodifluoromethane to yield a C1 source, which was successfully employed in the construction of various N-containing compounds e.g., C₆H₅N(CH₃)CH=NC₆H₅ especially with pharmaceutical mols. under mild conditions was reported. This strategy provides a useful method for late-stage modification of pharmaceutical compounds Four bonds in ClCF₂H were orderly cleaved under basic conditions in the absence of transition metals. Preliminary mechanistic studies revealed that (E)-N-phenylformimidoyl fluoride intermediate is involved in this process by in situ ¹H NMR studies and control experiments In the experiment, the researchers used many compounds, for example, 7-Methyl-1H-benzo[d]imidazole (cas: 4887-83-6Recommanded Product: 7-Methyl-1H-benzo[d]imidazole).

7-Methyl-1H-benzo[d]imidazole (cas: 4887-83-6) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole is incorporated into many important biological compounds. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Histidine is present in many proteins and enzymes, e.g. by binding metal cofactors, as seen in hemoglobin.Recommanded Product: 7-Methyl-1H-benzo[d]imidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Physiologically based pharmacokinetic modeling of candesartan related to CYP2C9 genetic polymorphism in adult and pediatric patients was written by Jung, Eui Hyun;Cho, Chang-Keun;Kang, Pureum;Park, Hye-Jung;Lee, Yun Jeong;Bae, Jung-Woo;Choi, Chang-Ik;Jang, Choon-Gon;Lee, Seok-Yong. And the article was included in Archives of Pharmacal Research in 2021.Name: 1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate This article mentions the following:

Candesartan cilexetil is an angiotensin II receptor blocker and it is widely used to treat hypertension and heart failure. This drug is a prodrug that rapidly converts to candesartan after oral administration. Candesartan is metabolized by cytochrome P 450 2C9 (CYP2C9) enzyme or uridine diphosphate glucurinosyltransferase 1A3, or excreted in an unchanged form through urine, biliary tract and feces. We investigated the effect of genetic polymorphism of CYP2C9 enzyme on drug pharmacokinetics using physiol. based pharmacokinetic (PBPK) modeling. In addition, by introducing the age and ethnicity into the model, we developed a model that can propose an appropriate dosage regimen taking into account the individual characteristics of each patient. To evaluate the suitability of the model, the results of a clin. trial on twenty-two healthy Korean subjects and their CYP2C9 genetic polymorphism data was applied. In this study, PK-Sim was used to develop the PBPK model of candesartan. In the experiment, the researchers used many compounds, for example, 1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate (cas: 145040-37-5Name: 1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate).

1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate (cas: 145040-37-5) belongs to imidazole derivatives. Imidazole is the basic core of some natural products such as histidine, purine, histamine and DNA based structures, etc. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.Name: 1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Effect of 4-amino-5-imidazolecarboxamide and related compounds on the growth of Entamoeba histolytica was written by Nakamura, Mitsuru. And the article was included in Canadian Journal of Microbiology in 1957.Application of 26832-08-6 This article mentions the following:

4-Amino-5-imidazolecarboxamide and 4-amino-5-imidazolecarboxamidine were found to be stimulatory to E. histolytica (NRS strain) when studied under bacteria-free conditions. These compounds in combination with folic acid or leucovorin, adenosinetriphosphate, and ribose-5-phosphate greatly stimulated amebic multiplication. Growth was measured qualitatively. In the experiment, the researchers used many compounds, for example, 1H-Imidazole-4-carboxamide (cas: 26832-08-6Application of 26832-08-6).

1H-Imidazole-4-carboxamide (cas: 26832-08-6) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. Imidazole also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes.Application of 26832-08-6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Quantum chemical aided prediction of the thermal decomposition mechanisms and temperatures of ionic liquids was written by Kroon, Maaike C.;Buijs, Wim;Peters, Cor J.;Witkamp, Geert-Jan. And the article was included in Thermochimica Acta in 2007.Formula: C7H13ClN2 This article mentions the following:

The long-term thermal stability of ionic liquids is of utmost importance for their industrial application. Although the thermal decomposition temperatures of various ionic liquids have been measured previously, exptl. data on the thermal decomposition mechanisms and kinetics are scarce. It is desirable to develop quant. chem. tools that can predict thermal decomposition mechanisms and temperatures (kinetics) of ionic liquids In this work ab initio quantum chem. calculations (DFT-B3LYP) have been used to predict thermal decomposition mechanisms, temperatures and the activation energies of the thermal breakdown reactions. These quantum chem. calculations proved to be an excellent method to predict the thermal stability of various ionic liquids In the experiment, the researchers used many compounds, for example, 1-Methyl-3-propylimidazolium Chloride (cas: 79917-89-8Formula: C7H13ClN2).

1-Methyl-3-propylimidazolium Chloride (cas: 79917-89-8) belongs to imidazole derivatives. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs. Imidazole has been usedin the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein, in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography, as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells.Formula: C7H13ClN2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Photoreactions of aromatic compounds. XXXVI. Nucleophilic photosubstitution reactions of some derivatives of imidazole and pyrazole was written by Oldenhof, C.;Cornelisse, J.. And the article was included in Recueil des Travaux Chimiques des Pays-Bas in 1978.Recommanded Product: 3034-41-1 This article mentions the following:

Nucleophilic photosubstitution of nitro derivatives of 1-methylimidazole and 1-methylpyrazole strongly depends on the position of the nitro group. In the imidazole series the 5-nitro compound is the most reactive isomer; photochem. replacement of the nitro group by cyano or methoxy proceeds in good yield. On the nitro-substituted 1-methylpyrazoles, the 3-nitro derivative is the most reactive isomer; photocyanation yields equal amounts of 1-methyl-3-nitro-4-cyanopyrazole and 1-methyl-3-nitrosopyrazole. Some of the reactions proceed by normal bimol. aromatic photosubstitution; others bear resemblance to the photoreactions of methoxybenzenes and -naphthalenes in which a cation radical is intermediate. In the experiment, the researchers used many compounds, for example, 1-Methyl-4-nitroimidazole (cas: 3034-41-1Recommanded Product: 3034-41-1).

1-Methyl-4-nitroimidazole (cas: 3034-41-1) belongs to imidazole derivatives. Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar. Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.Recommanded Product: 3034-41-1

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem