Month: December 2022

Sosnowski, Jerzy published the artcileElaboration of a preparation method of matrix tablets containing antazoline hydrochloride, HPLC of Formula: 2508-72-7, the publication is Farmacja Polska (1986), 42(8), 409-11, database is CAplus.

The matrix comprised poly(vinyl chloride), Et cellulose or Eudragit RL PM. Antazoline-HCl (I) was incorporated in the matrix by wet granulation. A solution of 10% Et cellulose in anhydrous EtOH, aqueous 4% solution of gelatin or 96% EtOH were used as binders. The in vitro release rate of I from these tablets was estimated by the half-exchange method.

Farmacja Polska published new progress about 2508-72-7. 2508-72-7 belongs to imidazoles-derivatives, auxiliary class Inhibitor,Immunology/Inflammation,Histamine Receptor, name is N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride, and the molecular formula is C18H23OP, HPLC of Formula: 2508-72-7.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Sosnowski, Jerzy published the artcilePreparation of prolonged-release tablets with antazoline hydrochloride by the mixed granulate method and double-layer tablets, Synthetic Route of 2508-72-7, the publication is Farmacja Polska (1986), 42(11), 611-15, database is CAplus.

One of the granulates used and one of the layers in the resulting tablets contained a hydrophobic matrix comprising poly(vinyl chloride). Two doses of the active substance were used as well as various excipients and various proportions of distribution of the active substance between the particular granulates or layers. The rate of in vitro release of antazoline-HCl from these tablets was estimated by the half-exchange method into artificial gastric and intestinal juices.

Farmacja Polska published new progress about 2508-72-7. 2508-72-7 belongs to imidazoles-derivatives, auxiliary class Inhibitor,Immunology/Inflammation,Histamine Receptor, name is N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride, and the molecular formula is C7H8BClO2, Synthetic Route of 2508-72-7.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Sosnowski, Jerzy published the artcileMethod for obtaining sustained-release antazoline hydrochloride tablets, Recommanded Product: N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride, the publication is Farmacja Polska (1985), 41(9), 524-9, database is CAplus.

Hydrophilic matrix tablets containing antazoline-HCl (I) [2508-72-7] were prepared by incorporation of hydroxpropyl Me cellulose  [9004-65-3]. Thus, double-layer tablets were obtained containing both the drug with an extended releasing rate (incorporated in the hydrophilic matrix) and the same drug with normal releasing rate. The release rate of I from these tablets was estimated by the half-exchange method.

Farmacja Polska published new progress about 2508-72-7. 2508-72-7 belongs to imidazoles-derivatives, auxiliary class Inhibitor,Immunology/Inflammation,Histamine Receptor, name is N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride, and the molecular formula is C8H11BO2, Recommanded Product: N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Kovar, Karl Artur published the artcileSilver perchlorate determination of halides and sulfates of nitrogen-containing bases, Name: N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride, the publication is Deutsche Apotheker Zeitung (1982), 122(47), 2421-3, database is CAplus.

The halides and sulfates of N-containing bases (drugs) are determined by potentiometric titration with AgClO₄ in HOAc-Ac₂O mixtures The principles of the titrimetric method are discussed and various exptl. procedures for the determination are given. The relative standard deviations obtained by Hg(OAc)₂ and AgClO₄ methods are compared for salts of various N-containing bases. 0He advantages of this method over the (HgOAc)₂ method are discussed. The method can be used for the determination of drugs in tablets.

Deutsche Apotheker Zeitung published new progress about 2508-72-7. 2508-72-7 belongs to imidazoles-derivatives, auxiliary class Inhibitor,Immunology/Inflammation,Histamine Receptor, name is N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride, and the molecular formula is C17H20ClN3, Name: N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Shekaari, Hemayat published the artcileEffective ultrasonic-assisted extraction and solubilization of curcuminoids from turmeric by using natural deep eutectic solvents and imidazolium-based ionic liquids, Product Details of C8H15ClN2, the publication is Journal of Molecular Liquids (2022), 119351, database is CAplus.

Curcuminoids (CURs), bioactive and antioxidant polyphenols, are major components of turmeric. Com. available component in CURs are curcumin (C) as the main constituent and the other two demethoxycurcumin (DMC) and bisdemethoxycurcumin (BDMC) as minor components. Extraction and anal. of these components from turmeric may pose specific challenges and yield different results. The organic solvents applied in traditional solvent extraction systems are not eco-friendly owing to their properties such as flammability, toxicity and volatility. For this reason, in this research work, ten deep eutectic solvents (DESs) and three ionic liquids (ILs) were selected to investigate the extraction of CURs from turmeric. Further, DES and ILs-based extraction was performed under ultrasound. Under extraction conditions, the CURs in the turmeric powder was measured by the use of high performance liquid chromatog. (HPLC). The maximum CURs amount of 164.51 mg/g was attained using effective ultrasound-assisted extraction in 50% water content DES or IL at 5% solid loading with 50.8 W/cm2 power intensity at 363 K in 60 min. This improved extraction method can be economical, green and effective alternative to conventional solvent extraction for CURs. On the other hand, the solubility of standard CUR was obtained at 298.15 K using saturation shake flask method. Finally, Hansen solubility parameters (HSP) were applied to identify solvents which were compatible with CURs. All the results were consistent with each other, supporting the validity of our extraction method.

Journal of Molecular Liquids published new progress about 79917-90-1. 79917-90-1 belongs to imidazoles-derivatives, auxiliary class Ionic Liquid,Ionic Liquid, name is 3-Butyl-1-methyl-1H-imidazol-3-ium chloride, and the molecular formula is C8H8O2, Product Details of C8H15ClN2.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Cho, Chul-Woong published the artcileIn silico prediction and analysis of dielectric constant of ionic liquids, Quality Control of 79917-90-1, the publication is Korean Journal of Chemical Engineering (2022), 39(6), 1651-1657, database is CAplus.

Ionic liquids (ILs) are a class of chems. comprising cations and anions whose properties can be controlled by modifying their chem. structure, which enables a wide range of applications. Among the attractive properties of ILs, dielec. permittivity provides important information related to material solvation and capacitor characteristics. Because there are several ILs and a need to understand the structural effect on their properties, prediction model(s) should be developed. For this, we employed the linear free-energy relationship (LFER) equation to predict the dielec. constant of ILs. In the modeling, we used in silico calculated mol. descriptors because the empirically LFER estimated descriptors were limited. The results revealed that the developed model could predict the dielec. constant with an R² of 0.882. From the developed model, it was observed that the dielec. constant was more affected by the structure of cations compared to that of anions. In addition, the H-bonding acidity of the cation and basicity of the anion contributed to the dielec. property of ILs, and the dipolarity/polarizability of cations and anions was also important in the prediction. The predictive model is expected to be useful for designing IL structures considering the dielec. constant

Korean Journal of Chemical Engineering published new progress about 79917-90-1. 79917-90-1 belongs to imidazoles-derivatives, auxiliary class Ionic Liquid,Ionic Liquid, name is 3-Butyl-1-methyl-1H-imidazol-3-ium chloride, and the molecular formula is C8H15ClN2, Quality Control of 79917-90-1.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Ke, Mi published the artcileSpatiotemporal profiling of cytosolic signalling complexes in living cells by selective proximity proteomics, SDS of cas: 901770-40-9, the publication is Nature Communications (2021), 12(1), 71, database is CAplus and MEDLINE.

Signaling complexes are often organized in a spatiotemporal manner and on a minute timescale. Proximity labeling based on engineered ascorbate peroxidase APEX2 pioneered in situ capture of spatiotemporal membrane protein complexes in living cells, but its application to cytosolic proteins remains limited due to the high labeling background. Here, we develop proximity labeling probes with increased labeling selectivity. These probes, in combination with label-free quant. proteomics, allow exploring cytosolic protein assemblies such as phosphotyrosine-mediated protein complexes formed in response to minute-scale EGF stimulation. As proof-of-concept, we systematically profile the spatiotemporal interactome of the EGFR signaling component STS1. For STS1 core complexes, our proximity proteomics approach shows comparable performance to affinity purification-mass spectrometry-based temporal interactome profiling, while also capturing addnl.-especially endosomally-located-protein complexes. In summary, we provide a generic approach for exploring the interactome of mobile cytosolic proteins in living cells at a temporal resolution of minutes.

Nature Communications published new progress about 901770-40-9. 901770-40-9 belongs to imidazoles-derivatives, auxiliary class Other Aliphatic Heterocyclic,Benzene,Phenol,Amide, name is N-(4-Hydroxyphenyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide, and the molecular formula is C16H21N3O3S, SDS of cas: 901770-40-9.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Lin, Lei published the artcileHigh-throughput method for in process monitoring of 3-O-sulfotransferase catalyzed sulfonation in bioengineered heparin synthesis, Recommanded Product: N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide, the publication is Analytical Biochemistry (2019), 113419, database is CAplus and MEDLINE.

Bioengineered heparin (BEH) offers a potential alternative for the preparation of a safer pharmacol. heparin. Construction of in-process control assays for tracking each enzymic step during bioengineered heparin synthesis remains a challenge. Here, we report a high-throughput sensing platform based on ELISA (ELISA) and enzymic signal amplification that allows the rapid and accurate monitoring of the 3-OST sulfonation in BEH synthesis process. The anticoagulant activity of target BEH was measured to reflect the degree of sulfonation by testing its competitive antithrombin (AT) binding ability. BEH samples with different sulfonation degrees show different AT protein binding capacity and thus changes the UV response to a different extent. This BEH-induced signal can be conveniently and sensitively monitored by the plate sensing system, which benefits from its high sensitivity brought in by the enzymic signal amplification. Furthermore, modification convenience and mech. robustness also ensure the stability of the test platform. This proposed strategy exhibits excellent anal. performance in both BEH activity anal. and 3-OST sulfonation evaluation. The simple and sensitive plate system shows great potential in developing on-chip, high-throughput methods for fundamental biochem. process research, drug discovery, and clinic diagnostics.

Analytical Biochemistry published new progress about 359860-27-8. 359860-27-8 belongs to imidazoles-derivatives, auxiliary class Other Aliphatic Heterocyclic,Chiral,Amine,Amide,Ether,Inhibitor, name is N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide, and the molecular formula is C18H34N4O5S, Recommanded Product: N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Wen, Li-Li published the artcileLow efficiency roll-off and high performance OLEDs employing alkyl group modified iridium(III) complexes as emitters, Formula: C19H14N2, the publication is RSC Advances (2016), 6(112), 111556-111563, database is CAplus.

Significant efficiency roll-off of phosphorescent organic light-emitting diodes (PHOLEDs) is a long-standing issue that limits their wider application. To address this problem, four iridium(III) complexes modified by Me or tert-Bu groups were designed and synthesized, denoted as Me-Ir-PI, tBu-Ir-PI, Me-Ir-PB, and tBu-Ir-PB. Their photophys., electrochem., and electroluminescent properties were studied in detail. The electroluminescent performances of devices based on tBu-Ir-PI and tBu-Ir-PB were better than those based on Me-Ir-PI and Me-Ir-PB. The best performance was achieved by the doped device employing tBu-Ir-PI as the emitter with maximum current efficiency of 42.0 cd A^-1 and maximum power efficiency of 27.0 lm W^-1. Even at a practical brightness of 1000 cd m^-2, the current efficiency and power efficiency remained as high as 39.2 cd A^-1 and 22.3 lm W^-1. Notably, all doped devices exhibited low efficiency roll-off, especially for device incorporation of tBu-Ir-PB as the guest emitter, which had extremely low roll-off of 0.9%. Meanwhile, non-doped devices based on these iridium(III) complexes also displayed good EL performances.

RSC Advances published new progress about 2622-67-5. 2622-67-5 belongs to imidazoles-derivatives, auxiliary class Benzimidazole,Benzene,Benzimidazole, name is 1,2-Diphenyl-1H-benzo[d]imidazole, and the molecular formula is C5H7NO, Formula: C19H14N2.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Wen, Li-Li published the artcileSimple molecular structure design of iridium(III) complexes: Achieving highly efficient non-doped devices with low efficiency roll-off, SDS of cas: 2622-67-5, the publication is Organic Electronics (2016), 142-150, database is CAplus.

To construct efficient emitters suitable for non-doped devices and deeply understand the relationship between structures and performances, we designed and synthesized two heteroleptic iridium(III) complexes based on 1,2-diphenyl-1H-benzoimidazole (PBI) ligands whose substituents are varied simply from Me (complex 2) to tert-Bu groups (complex 3). The parent complex 1 with non-substituent on PBI ligand has also been presented for a better comparison. Their photophys., electrochem. and electroluminescent (EL) performances are investigated systematically. Despite their structural modification, all complexes exhibit almost identical emission and excited-state characters, which are rationalized by the quantum-chem. calculations However, the obvious differences on device performances are found. Non-doped device employing 3 as emitting layer displays the highest EL performance with maximum current efficiency (η_c,max) of 18.6 cd A^-1 and power efficiency (η_p,max) of 16.2 lm W^-1 accompanied by low efficiency roll-off values, which is much higher than those of complexes 1 and 2. The obtained results herein suggest that introduction of the simple substituent into PBI ligand is an effective and feasible approach to develop highly efficient non-doped phosphors.

Organic Electronics published new progress about 2622-67-5. 2622-67-5 belongs to imidazoles-derivatives, auxiliary class Benzimidazole,Benzene,Benzimidazole, name is 1,2-Diphenyl-1H-benzo[d]imidazole, and the molecular formula is C15H24BN3O2, SDS of cas: 2622-67-5.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem