Month: December 2022

Zeng, Hui published the artcileA highly selective sulfur-free iridium(III)-complex-based phosphorescent chemidosimeter for detection of mercury(II) ions, Related Products of imidazoles-derivatives, the publication is Dalton Transactions (2012), 41(16), 4878-4883, database is CAplus and MEDLINE.

A neutral phosphorescent coordination compound bearing a benzimidazole ligand, Ir(pbi)₂(acac) (Hpbi = 1,2-diphenyl-1H-benzo[d]imidazole; Hacac = acetylacetone), is the 1st example of a sulfur-free iridium complex for the detection of Hg²⁺ cations with high selectivity and sensitivity. IR(pbi)₂(acac) shows a multi-signaling response towards mercury(ii) ions through UV-visible absorption, phosphorescence and electrochem. measurements. Upon addition of Hg²⁺ ions, solutions of this complex change from yellow to colorless, which could be observed easily by the naked eye, while its phosphorescence turns from bright green (λ_PLmax = 520 nm) into faint sky blue (λ_PLmax = 476 nm), and the detection limit is 2.4 × 10^-7 mol L^-1. ¹H NMR spectroscopic titration as well as ESI-MS results indicate that the decomposition of Ir(pbi)₂(acac) in the presence of Hg²⁺ through rupture of Ir-O bonds is responsible for the significant variations in both optical and electrochem. signals.

Dalton Transactions published new progress about 2622-67-5. 2622-67-5 belongs to imidazoles-derivatives, auxiliary class Benzimidazole,Benzene,Benzimidazole, name is 1,2-Diphenyl-1H-benzo[d]imidazole, and the molecular formula is C14H14, Related Products of imidazoles-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Aweke, Bamlaku Semagne published the artcileA Bis-(carbone) Pincer Ligand and Its Coordinative Behavior toward Multi-Metallic Configurations, Formula: C9H10N2O, the publication is Angewandte Chemie, International Edition (2022), 61(24), e202201884, database is CAplus and MEDLINE.

Carbones are divalent carbon(0) species that contain two lone pairs of electrons. Herein, authors have prepared the first known stable and isolable free bis-(carbone) pincer framework with a well-defined solid-state structure. This bis-(carbone) ligand is an effective scaffold for forming monometallic (Ni and Pd) and trinuclear heterometallic complexes with Au-Pd-Au, Au-Ni-Au, and Cu-Ni-Cu configurations. Sophisticated quantum-theor. analyses found that the metal-metal interactions are too weak to play a significant role in upholding these multi-metallic configurations; rather, the four lone pairs of electrons within the bis-(carbone) framework are the main contributors to the stability of the complexes.

Angewandte Chemie, International Edition published new progress about 7467-35-8. 7467-35-8 belongs to imidazoles-derivatives, auxiliary class Benzimidazole,Alcohol, name is (1-Methyl-1H-benzo[d]imidazol-2-yl)methanol, and the molecular formula is C9H10N2O, Formula: C9H10N2O.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Aweke, Bamlaku Semagne published the artcileA Bis-(carbone) Pincer Ligand and Its Coordinative Behavior toward Multi-Metallic Configurations, Recommanded Product: 2-(Chloromethyl)-1-methyl-1H-benzo[d]imidazole, the publication is Angewandte Chemie, International Edition (2022), 61(24), e202201884, database is CAplus and MEDLINE.

Carbones are divalent carbon(0) species that contain two lone pairs of electrons. Herein, authors have prepared the first known stable and isolable free bis-(carbone) pincer framework with a well-defined solid-state structure. This bis-(carbone) ligand is an effective scaffold for forming monometallic (Ni and Pd) and trinuclear heterometallic complexes with Au-Pd-Au, Au-Ni-Au, and Cu-Ni-Cu configurations. Sophisticated quantum-theor. analyses found that the metal-metal interactions are too weak to play a significant role in upholding these multi-metallic configurations; rather, the four lone pairs of electrons within the bis-(carbone) framework are the main contributors to the stability of the complexes.

Angewandte Chemie, International Edition published new progress about 4760-35-4. 4760-35-4 belongs to imidazoles-derivatives, auxiliary class Chloride,Benzimidazole, name is 2-(Chloromethyl)-1-methyl-1H-benzo[d]imidazole, and the molecular formula is C9H9ClN2, Recommanded Product: 2-(Chloromethyl)-1-methyl-1H-benzo[d]imidazole.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Ibrahim, S. A. published the artcileColorimetric method for the estimation of antazoline, Application of N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride, the publication is Indian Journal of Pharmacy (1974), 36(3), 73-5, database is CAplus.

A sensitive colorimetric method was developed for the determination of antazoline-HCl (I) [2508-72-7] in the pure state and in pharmaceutical preparations It depends on estimating the color produced when I was treated with nitrite. Thus, a 20 ml aliquot of I solution (stock solution contains 0.5% I-HCl in water) was treated with 4 ml NaNO2 solution (7.5% in concentrated H2SO4) 5 min at room temperature, and the solution was diluted to 50 ml with 15% aqueous AcONa. Absorbance was read within 10 min at 416 nm against a reagent blank. Data were given on the estimation of I by this method in pharmaceutical formulations. No interference was produced by phenylephrine-HCl [61-76-7], ephedrine-HCl [50-98-6], naphazoline-HCl [550-99-2], chlorobutanol [57-15-8], benzalkonium chloride, or polyethylene glycol [25322-68-3].

Indian Journal of Pharmacy published new progress about 2508-72-7. 2508-72-7 belongs to imidazoles-derivatives, auxiliary class Inhibitor,Immunology/Inflammation,Histamine Receptor, name is N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride, and the molecular formula is C17H20ClN3, Application of N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Kim, Jina published the artcileIdentification of selective ERRγ inverse agonists, Product Details of C7H7BN2O2, the publication is Molecules (2016), 21(1), 80/1-80/16, database is CAplus and MEDLINE.

GSK5182 (4) is currently one of the lead compounds for the development of estrogen-related receptor gamma (ERR) inverse agonists. Here, we report the design, synthesis, pharmacol. and in vitro absorption, distribution, metabolism, excretion, toxicity (ADMET) properties of a series of compounds related to 4. Starting from 4, a series of analogs were structurally modified and their ERR inverse agonist activity was measured. A key pharmacophore feature of this novel class of ligands is the introduction of a heterocyclic group for A-ring substitution in the core scaffold. Among the tested compounds, several of them are potent ERR inverse agonists as determined by binding and functional assays. The most promising compound, 15g, had excellent binding selectivity over related subtypes (IC50 = 0.44, >10, >10, and 10 μM at the ERR, ERRγ, ERR∝, and ERβ subtypes, resp.). Compound 15g also resulted in 95% transcriptional repression at a concentration of 10 _M, while still maintaining an acceptable in vitro ADMET profile. This novel class of ERR inverse agonists shows promise in the development of drugs targeting ERR-related diseases.

Molecules published new progress about 913835-63-9. 913835-63-9 belongs to imidazoles-derivatives, auxiliary class Other Aromatic Heterocyclic,Boronic acid and ester,Boronic Acids,Boronic acid and ester, name is Imidazo[1,2-a]pyridine-6-boronic acid, and the molecular formula is C7H7BN2O2, Product Details of C7H7BN2O2.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Yu, Dan published the artcileCuO nanoparticle-catalyzed diaminations for synthesis of benzimidazole derivatives, Name: 1,2-Diphenyl-1H-benzo[d]imidazole, the publication is Applied Organometallic Chemistry (2016), 30(8), 695-698, database is CAplus.

Copper oxide nanoparticles were applied as an efficient catalyst for the formation of C-N bonds. They can catalyze diaminations for the regiospecific synthesis of 1,2-disubstituted benzimidazoles from 1,2-dihaloarenes and N-arylamidines. The best performance was achieved using CuO nanoparticles with average diameter of 6.5 nm. In addition, the catalyst can be recycled and reused without any significant decrease in catalytic activity.

Applied Organometallic Chemistry published new progress about 2622-67-5. 2622-67-5 belongs to imidazoles-derivatives, auxiliary class Benzimidazole,Benzene,Benzimidazole, name is 1,2-Diphenyl-1H-benzo[d]imidazole, and the molecular formula is C9H5ClO2, Name: 1,2-Diphenyl-1H-benzo[d]imidazole.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Sun, Qiao published the artcileCobalt-catalyzed C(sp²)-H/C(sp³)-H coupling via directed C-H activation and 1,5-hydrogen atom transfer, Synthetic Route of 258278-25-0, the publication is Organic Chemistry Frontiers (2018), 5(4), 582-585, database is CAplus.

The regioselective synthesis of 1-[2-[(benzylamino)methyl]phenyl]ethanones such as I [R = H, 3-Cl, 4-Ph, etc.; R¹ = Me, n-Pr; R² = Et, n-Bu; R¹R² = (CH₂)₃, (CH₂)₄, (CH₂)₅, etc.] via cobalt-catalyzed C(sp²)-H/C(sp³)-H cross-coupling reaction between various (E)-aryl imines and 2-bromobenzyl-protected secondary amines was reported. Promoted by a combination of a cobalt-N-heterocyclic carbene catalyst and Grignard reagent, the reaction was allowed for the introduction of α-aminoalkyl groups into the ortho position of the imine at a mild temperature The cobalt catalyst was proposed to play key roles in two distinct modes of C-H cleavage, i.e., directed C-H metalation and 1,5-hydrogen atom transfer.

Organic Chemistry Frontiers published new progress about 258278-25-0. 258278-25-0 belongs to imidazoles-derivatives, auxiliary class Achiral NHCs Ligands, name is 1,3-Bis(2,6-diisopropylphenyl)-4,5-dihydro-1H-imidazol-3-ium chloride, and the molecular formula is C7H5Cl2NO, Synthetic Route of 258278-25-0.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Lee, Kyung-Bok published the artcileSurface modification of poly(glycolic acid) (PGA) for biomedical applications, Related Products of imidazoles-derivatives, the publication is Journal of Pharmaceutical Sciences (2003), 92(5), 933-937, database is CAplus and MEDLINE.

The immobilization of biol. ligands (such as biotin and peptides) onto biodegradable polymer surfaces, including poly(glycolic acid) (PGA) sutures, is complicated by the absence of functional groups on the polymer backbone. We demonstrate a method for overcoming this problem, by attaching (+)-biotinyl-3,6,9-trioxaundecanediamine to the surface of PGA sutures, which immobilizes the ligand through an amide bond between amine (ligands) and carboxylic acid groups (surface-hydrolyzed PGA sutures). Fluorescence microscopy was used to verify the attachment of the biotin ligand to the surface of the PGA suture after a complexation with fluorescein-conjugated streptavidin. The strategy can be generalized to surface modifications of other biodegradable aliphatic polyesters, which would improve the properties of the polymers in biomedical applications such as active targeting of drugs based on ligand-attached, polymeric drug delivery systems.

Journal of Pharmaceutical Sciences published new progress about 359860-27-8. 359860-27-8 belongs to imidazoles-derivatives, auxiliary class Other Aliphatic Heterocyclic,Chiral,Amine,Amide,Ether,Inhibitor, name is N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide, and the molecular formula is C18H34N4O5S, Related Products of imidazoles-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Arimoto, Masahiro published the artcileSemisynthetic β-lactam antibiotics. IV. Synthesis and antibacterial activity of 7β-[2-(hetero aromatic methoxyimino)-2-(2-aminothiazol-4-yl)acetamido]cephalosporins, Product Details of C5H8N2O, the publication is Journal of Antibiotics (1988), 41(12), 1795-811, database is CAplus and MEDLINE.

Title compounds I [R = OAc, 1-methyl-5-tetrazolylthio, (un)substituted pyridinium, 1-methylpyrrolidinium, pyridazinium; R¹ = (un)substituted imidazol-4-yl, 1,2,3-triazol-4-yl, pyridazin-3-yl, pyrimidin-4-yl, pyrazinyl] were synthesized and bacteriol. evaluated. Several I showed exceptional in vitro activity. The most active derivative, I (R = pyridinium, R¹ = imidazol-4-yl), was the most evenly balanced with respect to activity against Gram-pos. and Gran-neg. bacteria. Furthermore, I (R = pyridinium, R¹ = imidazol-4-yl) was stable to various types of β-lactamases and had high affinities for penicillin binding protein-3 and -1Bs of both Escherichia coli and Pseudomonas aeruginosa.

Journal of Antibiotics published new progress about 45533-87-7. 45533-87-7 belongs to imidazoles-derivatives, auxiliary class Imidazole,Alcohol,Imidazole, name is (2-Methyl-1H-imidazol-4-yl)methanol, and the molecular formula is C5H8N2O, Product Details of C5H8N2O.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Peng, Jinsong published the artcileCopper-catalyzed intramolecular C-N bond formation: a straightforward synthesis of benzimidazole derivatives in water, Product Details of C19H14N2, the publication is Journal of Organic Chemistry (2011), 76(2), 716-719, database is CAplus and MEDLINE.

A straightforward, efficient, and more sustainable copper-catalyzed method has been developed for intramol. N-arylation providing the benzimidazole ring system. With Cu₂O (5 mol %) as the catalyst, DMEDA (10 mol %) as the ligand, and K₂CO₃ as the base, this protocol was applied to synthesize a small library of benzimidazoles, e.g., I in high yields. Remarkably, the reaction was exclusively carried out in water, rendering the methodol. highly valuable from both environmental and economical points of view.

Journal of Organic Chemistry published new progress about 2622-67-5. 2622-67-5 belongs to imidazoles-derivatives, auxiliary class Benzimidazole,Benzene,Benzimidazole, name is 1,2-Diphenyl-1H-benzo[d]imidazole, and the molecular formula is C19H14N2, Product Details of C19H14N2.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem