Month: December 2022

Chang, Jinyu published the artcilePreparation of 5-methyl-3,5-dipropyl-2-pyrazoline catalyzed by chloroaluminate ionic liquids, Safety of 3-Butyl-1-methyl-1H-imidazol-3-ium chloride, the publication is Journal of Molecular Structure (2022), 132539, database is CAplus.

5-Methyl-3,5-dipropyl-2-pyrazoline is an intermediate for the preparation of new high energy fuels. In this paper, chloroaluminate ionic liquids ([Bmim]Cl-xAlCl₃, x = 1, 1.2, 1.4, 1.6, 1.8, 2.0) were applied as green catalysts for the synthesis of 5-methyl-3,5-dipropyl-2-pyrazoline through the intramol. cyclization reaction of 2-pentyl ketazine. The effects of temperature, acidity and dosage of ionic liquids on the cyclization reaction were studied in detail and the highest catalytic performance was under the conditions as 110°, [Bmim]Cl-1.6AlCl₃ and 10% of 2-pentyl ketazine. With the theor. simulations, the possible catalytic mechanism was proposed as the hydrogen-like interaction between Al ([Bmim]⁺AlCl₄^–) and N1 atoms, which increases the charge of N2 atoms, thereby improving its nucleophilicity and further making it undergo intramol. addition reaction with Me. This study will provide guidance for the green preparation of 5-methyl-3,5-dipropyl-2-pyrazoline.

Journal of Molecular Structure published new progress about 79917-90-1. 79917-90-1 belongs to imidazoles-derivatives, auxiliary class Ionic Liquid,Ionic Liquid, name is 3-Butyl-1-methyl-1H-imidazol-3-ium chloride, and the molecular formula is C8H15ClN2, Safety of 3-Butyl-1-methyl-1H-imidazol-3-ium chloride.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Lambert, Alexander published the artcileUltrasensitive Detection of Bacterial Protein Toxins on Patterned Microarray via Surface Plasmon Resonance Imaging with Signal Amplification by Conjugate Nanoparticle Clusters, Quality Control of 359860-27-8, the publication is ACS Sensors (2018), 3(9), 1639-1646, database is CAplus and MEDLINE.

Sensitive detection and monitoring of biol. interactions in a high throughput, multiplexed array format has numerous advantages. We report here a method to enhance detection sensitivity in surface plasmon resonance (SPR) spectroscopy and SPR imaging via the effect of accumulation of conjugated nanoparticles of varying sizes. Bacterial cholera toxin (CT) was chosen for the demonstration of enhanced immunoassay by SPR. After immobilization of CT on a gold surface, specific recognition is achieved by biotinylated anti-CT. The signal is amplified by the attachment of biotinylated 20nm AuNP via streptavidin bridge, followed by attachment of 5nm streptavidin-functionalized Fe3O4NP to the AuNP-biotin surface. The continuous surface binding of two differently-sized conjugated nanoparticles effectively increase their packing d. on surface; significantly improve SPR detection sensitivity, allowing quant. measurement of CT at very low concentration The dense packing of conjugated nanoparticles on the surface was confirmed by at. force microscopy characterization. SPR imaging of the immunoassay for high-throughput anal. utilized an Au-well microarray that attenuated the background resonance interference on the resulting images. A calibration curve of conjugated nanoparticle binding signal amplification for CT detection based on surface coverage has been obtained that shows a correlation in a range from 6.31 × 10-16 to 2.51 × 10-13 mol/cm2 with the limit of detection of 5.01 × 10-16 mol/cm2. The absolute quantity of detection limit using SPR imaging was 0.25 fmol. The versatile nanoparticles and biotin-streptavidin interaction used here should allow adaptation of this enhancement method to many other systems that include DNA, RNA, peptides, and carbohydrates, opening new avenues for ultrasensitive anal. of biomols.

ACS Sensors published new progress about 359860-27-8. 359860-27-8 belongs to imidazoles-derivatives, auxiliary class Other Aliphatic Heterocyclic,Chiral,Amine,Amide,Ether,Inhibitor, name is N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide, and the molecular formula is C18H34N4O5S, Quality Control of 359860-27-8.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Hu, Xutao published the artcileElucidating the transition between CO₂ physisorption and chemisorption in 1,2,4-triazolate ionic liquids at a molecular level, HPLC of Formula: 79917-90-1, the publication is Chemical Engineering Journal (Amsterdam, Netherlands) (2022), 435(Part_2), 134956, database is CAplus.

Capture of CO₂ is a crucial process to achieve carbon neutrality. High-performance CO₂ capture involves both physi- and chemi-sorption, with a transition between them. However, the underlying mechanistic insights required to produce the methods to tune the transition are poorly understood. Here, we describe a series of 1,2,4-triazolate ionic liquids (TZ ILs) that capture > 0.7 mol CO₂ /mol TZ IL in a two-stage absorption process. Physi- and chemi-sorption were studied by spectroscopy using ¹³CO₂ and the transition between the two sorption modes has been identified. UV-Vis, FT-IR and NMR spectroscopy as well as d. and viscosity measurements demonstrate that physisorption is initially the dominant process whereas later chemisorption predominates. Based on the identification of key species combined with theor. modeling, a plausible mol.-level mechanism is proposed for the transition between the two sorption modes. These mechanistic insights enable the transition of CO₂ capture to be tuned.

Chemical Engineering Journal (Amsterdam, Netherlands) published new progress about 79917-90-1. 79917-90-1 belongs to imidazoles-derivatives, auxiliary class Ionic Liquid,Ionic Liquid, name is 3-Butyl-1-methyl-1H-imidazol-3-ium chloride, and the molecular formula is C8H15ClN2, HPLC of Formula: 79917-90-1.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Zhao, Wangdan published the artcileDetermination and Thermodynamic Modeling of Solid-Liquid Phase Equilibrium for Esomeprazole Sodium in Monosolvents and in the (Ethanol + Ethyl Acetate) Binary Solvent Mixtures, Product Details of C17H18N3NaO3S, the publication is Journal of Chemical & Engineering Data (2017), 62(7), 1965-1972, database is CAplus.

Esomeprazole sodium was a proton pump inhibitor (PPI) synthesized using omeprazole sulfide. In this paper, we used a static-analytic method to analyze the solubility of our own synthesis of esomeprazole sodium in Et acetate, acetonitrile, Me iso-Bu ketone, ethanol, methanol, and in the (ethanol + Et acetate) mixtures between 278.15 and 328.15 K. A group of thermodn. models were selected such as the Jouyban-Acree equation, the modified Apelblat equation, and CNIBS/R-K equations. All equations can be well applied and the modified Apelblat equations are relatively better. We determined the thermodn. properties of esomeprazole sodium using the van’t Hoff equation furthermore, including the entropy, Gibbs energy, and enthalpy.

Journal of Chemical & Engineering Data published new progress about 161796-78-7. 161796-78-7 belongs to imidazoles-derivatives, auxiliary class Membrane Transporter/Ion Channel,Proton Pump, name is Sodium (S)-6-methoxy-2-(((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide, and the molecular formula is C15H21BO3, Product Details of C17H18N3NaO3S.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Zhang, Ming published the artcileChemical reaction within a compact non-porous crystal containing molecular clusters without the loss of crystallinity, Safety of (1-Methyl-1H-benzo[d]imidazol-2-yl)methanol, the publication is Chemical Science (2017), 8(8), 5356-5361, database is CAplus and MEDLINE.

The very rare occurrence of a gas-solid chem. reaction has been found to take place on a mol. within a compact non-porous crystal without destroying its long-range structural order and retaining similar crystal structures when yellow crystals of Fe^II₄(mbm)₄Cl₄(MeOH)₄ were exposed to air to give black [Fe^III₄(mbm)₄Cl₄(OH)₄]·2H₂O. The latter cannot be synthesized directly. The original cluster underwent an exchange of methanol to hydroxide, an oxidation of Fe(II) to Fe(III), a change in stereochem. and hydration while the packing and space-group remained unaltered.

Chemical Science published new progress about 7467-35-8. 7467-35-8 belongs to imidazoles-derivatives, auxiliary class Benzimidazole,Alcohol, name is (1-Methyl-1H-benzo[d]imidazol-2-yl)methanol, and the molecular formula is C6H6N2O, Safety of (1-Methyl-1H-benzo[d]imidazol-2-yl)methanol.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Bai, Zheng-Wu published the artcileEvaluation and comparison of N-cycloalkylformylated chitosan bis(arylcarbamate)s as chiral selectors for enantioseparation, COA of Formula: C17H18N3NaO3S, the publication is New Journal of Chemistry (2017), 41(19), 10561-10567, database is CAplus.

To systematically study the structural dependence on the properties of N-cycloalkylformylated chitosan bis(arylcarbamate)s, 3,5-dimethylphenylcarbamates of N-cyclopropylformylated, N-cyclobutylformylated, N-cyclopentylformylated and N-cyclohexylformylated chitosans were prepared as chiral selectors. Since both the mol. weights of chitosan and the substituents at the 3- and 6-positions of the phenylcarbamates are identical, the influences of the substituent at the 2-position on the solvent tolerability and enantioseparation performance of the chiral selectors were specifically compared and discussed. The solvent tolerability and enantioseparation performances of the chiral selectors obviously differed with the variation of the substituent at the 2-position of the glucosamine skeleton. Although all the chiral selectors generally showed satisfactory tolerability in Et acetate and acetone, the chiral selector with a three-membered ring exhibited much more preferable tolerability against THF than the others with a four-, five- or six-membered ring. Enantioseparation results revealed that most of the chiral selectors exhibited powerful chiral recognition and enantioseparation abilities, and the chiral selector with a five-membered ring exhibited the best enantioseparation performance. The corresponding coated-type chiral stationary phases prepared from these chitosan-based chiral selectors were able to be complementary with each other and applied as promising chiral separation materials for enantiomeric separations

New Journal of Chemistry published new progress about 161796-78-7. 161796-78-7 belongs to imidazoles-derivatives, auxiliary class Membrane Transporter/Ion Channel,Proton Pump, name is Sodium (S)-6-methoxy-2-(((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide, and the molecular formula is C17H18N3NaO3S, COA of Formula: C17H18N3NaO3S.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Zhao, Panpan published the artcileA simple preparation method for rare-earth phosphate nano materials using an ionic liquid-driven supported liquid membrane system, Product Details of C16H23F6N3O2, the publication is Journal of Industrial and Engineering Chemistry (Amsterdam, Netherlands) (2017), 369-376, database is CAplus.

For the first time, our group has developed a novel, high-flux strategy for shape-controlled synthesis of rare earth nano-materials (CePO₄) using ionic liquid(IL)-driven supported liquid membrane (HVHP, DUPAPORE) system. The system contains three phases including a supply phase of rare earth ions, a feed phase of phosphates, and ionic liquid-driven supporting liquid membrane phase. The imidazolium IL-driven supported liquid membrane is promising for nano-synthetic reaction of CePO₄. The anion types of immersed imidazolium IL have a critical role in the formation rate of CePO₄ nano-materials. Moreover, the adding SO^2-₄ anion or adjustment of pH in supply phase containing Ce(III) ions could control effectively the morphol. of the CePO₄ nano-materials. The result can be regarded as a good example, the IL:[C₄mim][Tf₂N] -driven support liquid membrane systems can be used to prepare nano-wire and nano-sphere structures of CePO₄ with high efficiency and flux. Besides, the IL-driven supported liquid membrane can be cycled many times by using the back flush activation method.

Journal of Industrial and Engineering Chemistry (Amsterdam, Netherlands) published new progress about 862731-66-6. 862731-66-6 belongs to imidazoles-derivatives, auxiliary class Ionic Liquid, name is 1-octyl-3-methylimidazolium bis((trifluoromethyl)sulfonyl)imide, and the molecular formula is C10H10O3, Product Details of C16H23F6N3O2.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Wang, Yue-mei published the artcileNew synthesis of fungicide cyazofamid, Synthetic Route of 120118-14-1, the publication is Nongyao (2015), 54(5), 324-326, database is CAplus.

Aims: This paper aims to report the new synthesis of fungicide cyazofamid. Methods: The compound was synthesized using 4-acetyltoluene as raw materials, through reactions of the oxidation, esterification, ammoniation, dehydration, chlorination and sulfonylation to obtain cyazofamid. And the paper mainly discussed the optimum process conditions for synthesizing substituted imidazole ring: reaction temperature is 85°C, reaction time is 10 h, ethanol as the solvent and n[2-oxo-2-(p-tolyl)acetaldehyde]:n[(NH₄)₂CO₄]:n[glyoxylic acid (50% water solution) ]:n(triethylamine) = 1:1.5:3:5. Results: The total yield was 37.0%. Conclusions: The process is simple, the reaction conditions are mild, all the intermediates are easy to be purified and identified.

Nongyao published new progress about 120118-14-1. 120118-14-1 belongs to imidazoles-derivatives, auxiliary class Imidazole,Chloride,Nitrile,Benzene, name is 4-Chloro-5-(p-tolyl)-1H-imidazole-2-carbonitrile, and the molecular formula is C8H6ClN, Synthetic Route of 120118-14-1.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Chen, Tao published the artcileSynthesis of 4(5)-chloro-2-cyano-5(4)-(4-methylphenyl)imidazole, Product Details of C11H8ClN3, the publication is Huaxue Shiji (2015), 37(6), 571-573, database is CAplus.

Compound 4-chloro-2-cyano-5-(4-methylphenyl)imidazole was synthesized from 4-methylacetophenone. It started from oxidation using selenium dioxide and cyclization by hydroxylamine and glyoxal solution to give 4-hydro-5-(4-methylphenyl)-2-oxyiminomethylimidazole-3-oxide as the key intermediate. Then, the process was followed by dehydration and chlorination with thionyl chloride and N,N-dimethylformamide. The overall yield was 69.0% (based on 4′-methylacetophenone).

Huaxue Shiji published new progress about 120118-14-1. 120118-14-1 belongs to imidazoles-derivatives, auxiliary class Imidazole,Chloride,Nitrile,Benzene, name is 4-Chloro-5-(p-tolyl)-1H-imidazole-2-carbonitrile, and the molecular formula is C11H8ClN3, Product Details of C11H8ClN3.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Xia, Pin-si published the artcileDetermination of related substances in esomeprazole sodium for injection by RP-HPLC, Computed Properties of 161796-78-7, the publication is Zhongnan Yaoxue (2014), 12(11), 1131-1135, database is CAplus.

An RP-HPLC method to determine the related substances in esomeprazole sodium for injection was established. The determination was performed on a Inerstil ODS-3 column (150 mm×4.6 mm, 5 μm), with a mobile phase consisting of a mixture of acetonitrile and phosphate buffer (pH=7.4) and tetrabutylammonium hydrogen sulfate. The column temperature was 30°C at 1.0 mL·min^-1 and the detective wavelength was 280 nm. The related substances were completely separated from the main constituent. Impurity A and B were stable in 24 h under the condition of frozen dark, but impurity C was not stable. Omeprazole and impurity A, B and C had good linearity at 0.0633-2.1108 μg·mL^-1 (r=1.000), 0.1465-1.9538 μg·mL^-1 (r=1.000), 0.1587-1.9835 μg·mL^-1 (r=0.9999), 0.0576-3.8388 μg·mL^-1 (r=0.9996) resp. The recoveries were at 91%-105%, and RSDs were less than 5%, which could be meet the requirements. The method can be used for the quality control of esomeprazole sodium for injection.

Zhongnan Yaoxue published new progress about 161796-78-7. 161796-78-7 belongs to imidazoles-derivatives, auxiliary class Membrane Transporter/Ion Channel,Proton Pump, name is Sodium (S)-6-methoxy-2-(((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide, and the molecular formula is C4H5BN2O2, Computed Properties of 161796-78-7.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem