Month: December 2022

Parada, Walter A. published the artcileCO₂ Electroreduction on Silver Foams Modified by Ionic Liquids with Different Cation Side Chain Length, SDS of cas: 79917-90-1, the publication is ACS Applied Materials & Interfaces (2022), 14(12), 14193-14201, database is CAplus and MEDLINE.

Ionic liquids (ILs) are capable of tuning the kinetics of electroreduction processes by modifying a catalyst interface. A group of hydrophobic imidazolium-based ILs were immobilized on Ag foams by using a procedure known as solid catalyst with ionic liquid layer (SCILL). The derived electrocatalysts demonstrated altered selectivity and CO production rates for the electrochem. reduction of CO₂ compared to the unmodified Ag foam. The activity change caused by the IL was dependent on the length of the N-alkyl substituent. The rate of CO production is optimized at moderate chain length and IL loadings. The observed trends are attributed to a local enrichment of CO₂-based species in the proximity of the catalyst and a modification of the environment of its active sites. On the contrary, high loadings or long IL chains render the surface inaccessible and favor the H evolution reaction.

ACS Applied Materials & Interfaces published new progress about 79917-90-1. 79917-90-1 belongs to imidazoles-derivatives, auxiliary class Ionic Liquid,Ionic Liquid, name is 3-Butyl-1-methyl-1H-imidazol-3-ium chloride, and the molecular formula is C8H15ClN2, SDS of cas: 79917-90-1.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Melis-Decerf, C. published the artcileAn in vitro method simulating drug release from viscous eye drops in rabbit and man, Category: imidazoles-derivatives, the publication is Journal of Pharmacy and Pharmacology (1979), 31(1), 12-15, database is CAplus and MEDLINE.

The release of drugs from viscous solutions under conditions simulating the blinking movements in the rabbit and human eye was determined using a rotatable diffusion cell. For the solutions at rest, corresponding with the conditions at the surface of the rabbit cornea, the diffusion velocity decreased with increasing viscosity. When the solution was moved at a velocity corresponding to that of lacrimal fluid at the surface of the human eye, the influence of viscosity may be neglected.

Journal of Pharmacy and Pharmacology published new progress about 2508-72-7. 2508-72-7 belongs to imidazoles-derivatives, auxiliary class Inhibitor,Immunology/Inflammation,Histamine Receptor, name is N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride, and the molecular formula is C17H20ClN3, Category: imidazoles-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Hassan, Mujtaba published the artcileBenzimidazole-galactosides bind selectively to the Galectin-8 N-Terminal domain: Structure-based design and optimization, Computed Properties of 4760-35-4, the publication is European Journal of Medicinal Chemistry (2021), 113664, database is CAplus and MEDLINE.

We have obtained the X-ray crystal structure of the galectin-8 N-terminal domain (galectin-8N) with a previously reported quinoline-galactoside ligand at a resolution of 1.6 Å. Based on this X-ray structure, a collection of galactosides derivatized at O3 with triazole, benzimidazole, benzothiazole, and benzoxazole moieties were designed and synthesized. This led to the discovery of a 3-O-(N-methylbenzimidazolylmethyl)-galactoside with a K_d of 1.8μM for galectin-8N, the most potent selective synthetic galectin-8N ligand to date. Mol. dynamics simulations showed that benzimidazole-galactoside derivatives bind the non-conserved amino acid Gln47, accounting for the higher selectivity for galectin-8N. Galectin-8 is a carbohydrate-binding protein that plays a key role in pathol. lymphangiogenesis, modulation of the immune system, and autophagy. Thus, the benzimidazole-derivatized galactosides, e.g. I, represent promising compounds for studies of the pathol. implications of galectin-8, as well as a starting point for the development of antitumor and antiinflammatory therapeutics targeting galectin-8.

European Journal of Medicinal Chemistry published new progress about 4760-35-4. 4760-35-4 belongs to imidazoles-derivatives, auxiliary class Chloride,Benzimidazole, name is 2-(Chloromethyl)-1-methyl-1H-benzo[d]imidazole, and the molecular formula is C9H9ClN2, Computed Properties of 4760-35-4.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Van Gyseghem, E. published the artcileDetermining orthogonal chromatographic systems prior to the development of methods to characterise impurities in drug substances, Product Details of C17H20ClN3, the publication is Journal of Chromatography, A (2003), 988(1), 77-93, database is CAplus and MEDLINE.

To define starting conditions for the development of methods to sep. impurities from the active substance and from each other in drugs with an unknown impurity profile, the parallel application of generic orthogonal chromatog. systems could be useful. The possibilities to define orthogonal chromatog. systems were examined by calculation of the correlation coefficients between retention factors k for a set of 68 drugs on 11 systems, by visual evaluation of the selectivity differences, by principal component anal., by drawing color maps, and evaluating dendrograms. A zirconia-based stationary phase coated with a polybutadiene (PBD) polymer and 3 silica-based phases (base-deactivated, polar-embedded and monolithic) were used. Besides the stationary phase, the influence of pH and of organic modifier, on the selectivity of a system were evaluated. The dendrograms of hierarchical clusters were found good aids to assess orthogonality of chromatog. systems. The PBD-zirconia phase/methanol/pH 2.5 system is found most orthogonal towards several silica-based systems, e.g. a base-deactivated C₁₆-amide silica/methanol/pH 2.5 system. The orthogonality was validated using cross-validation, and 2 other validation sets, i.e. a set of non-ionizable solutes and a mixture of a drug and its impurities.

Journal of Chromatography, A published new progress about 2508-72-7. 2508-72-7 belongs to imidazoles-derivatives, auxiliary class Inhibitor,Immunology/Inflammation,Histamine Receptor, name is N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride, and the molecular formula is C7H16Cl2Si, Product Details of C17H20ClN3.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Mesa, Leyanis published the artcileOptimization of BmimCl pretreatment of sugarcane bagasse through combining multiple responses to increase sugar production. An approach of the kinetic model, HPLC of Formula: 79917-90-1, the publication is Biomass Conversion and Biorefinery (2022), 12(6), 2027-2043, database is CAplus.

Sugarcane bagasse (SCB) was pretreated with 1-butyl-3-methylimidazolium chloride (BmimCl) at different conditions of temperature (80°C to 150°C) and solid loading (4 to 10%) at two times (20 and 60 min). The pretreatment conditions were optimized using a central composite rotatable design (CCRD) and desirability function having in mind the principles of green engineering. The pretreatments resulted in modifications of morphol. and structural characteristics of biomass, also resulting in partial hemicellulose reduction The founded optimal condition of pretreatment under the criterion of maximized sugar yield after enzymic hydrolysis and minimized total sugar loss in pretreatment was 140°C and 6% weight/weight of solid loading with 20 min of process. Also, a kinetic model was obtained verifying its validity with exptl. values. It showed a lower activation energy of cellulose modification and hemicellulose conversion in comparison with the literature. One of the major findings was the strong correlation between glucose conversion and the d.p.

Biomass Conversion and Biorefinery published new progress about 79917-90-1. 79917-90-1 belongs to imidazoles-derivatives, auxiliary class Ionic Liquid,Ionic Liquid, name is 3-Butyl-1-methyl-1H-imidazol-3-ium chloride, and the molecular formula is C8H15ClN2, HPLC of Formula: 79917-90-1.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Nagatsuka, Takehiro published the artcileGlycotechnology for Decontamination of Biological Agents: A Model Study Using Ricin and Biotin-Tagged Synthetic Glycopolymers, COA of Formula: C18H34N4O5S, the publication is ACS Applied Materials & Interfaces (2012), 4(2), 832-837, database is CAplus and MEDLINE.

Two types of biotin-tagged glycopolymers carrying lactose or glucose in clusters along the polyacrylamide backbone were prepared and subjected to decontamination analyses with the plant toxin ricin. A buffer solution containing the toxin was treated with one glycopolymer followed by streptavidin-magnetic particles. Supernatant solutions were analyzed with surface plasmon resonance and capillary electrophoresis, and revealed that the lactose glycopolymer “captured” this toxin more effectively than the glucose polymer. Free toxin was not detectable in the supernatant after treatment with the glycopolymer and magnetic particles; >99% decontamination was achieved for this potentially fatal biol. toxin.

ACS Applied Materials & Interfaces published new progress about 359860-27-8. 359860-27-8 belongs to imidazoles-derivatives, auxiliary class Other Aliphatic Heterocyclic,Chiral,Amine,Amide,Ether,Inhibitor, name is N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide, and the molecular formula is C18H34N4O5S, COA of Formula: C18H34N4O5S.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Pohjala, Leena published the artcileInhibitors of alphavirus entry and replication identified with a stable Chikungunya replicon cell line and virus-based assays, Synthetic Route of 2508-72-7, the publication is PLoS One (2011), 6(12), e28923, database is CAplus and MEDLINE.

Chikungunya virus (CHIKV), an alphavirus, has recently caused epidemic outbreaks and is therefore considered a re-emerging pathogen for which no effective treatment is available. In this study, a CHIKV replicon containing the virus replicase proteins together with puromycin acetyltransferase, EGFP and Renilla luciferase marker genes was constructed. The replicon was transfected into BHK cells to yield a stable cell line. A non-cytopathic phenotype was achieved by a Pro718 to Gly substitution and a five amino acid insertion within non-structural protein 2 (nsP2), obtained through selection for stable growth. Characterization of the replicon cell line by Northern blotting anal. revealed reduced levels of viral RNA synthesis. The CHIKV replicon cell line was validated for antiviral screening in 96-well format and used for a focused screen of 356 compounds (natural compounds and clin. approved drugs). The 5,7-dihydroxyflavones apigenin, chrysin, naringenin and silybin were found to suppress activities of EGFP and Rluc marker genes expressed by the CHIKV replicon. In a concomitant screen against Semliki Forest virus (SFV), their anti-alphaviral activity was confirmed and several addnl. inhibitors of SFV with IC₅₀ values between 0.4 and 24 μM were identified. Chlorpromazine and five other compounds with a 10H-phenothiazinyl structure were shown to inhibit SFV entry using a novel entry assay based on a temperature-sensitive SFV mutant. These compounds also reduced SFV and Sindbis virus-induced cytopathic effect and inhibited SFV virion production in virus yield experiments Finally, antiviral effects of selected compounds were confirmed using infectious CHIKV. In summary, the presented approach for discovering alphaviral inhibitors enabled us to identify potential lead structures for the development of alphavirus entry and replication phase inhibitors as well as demonstrated the usefulness of CHIKV replicon and SFV as biosafe surrogate models for anti-CHIKV screening.

PLoS One published new progress about 2508-72-7. 2508-72-7 belongs to imidazoles-derivatives, auxiliary class Inhibitor,Immunology/Inflammation,Histamine Receptor, name is N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride, and the molecular formula is C17H20ClN3, Synthetic Route of 2508-72-7.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Castillo, Ivan published the artcileStructural, spectroscopic, and electrochemical properties of tri- and tetradentate N₃ and N₃S copper complexes with mixed benzimidazole/thioether donors, Formula: C9H9ClN2, the publication is Dalton Transactions (2012), 41(31), 9394-9404, database is CAplus and MEDLINE.

Cupric and cuprous complexes of bis(2-methylbenzimidazolyl)(2-methylthiophene)amine (L¹), bis(2-methylbenzimidazolyl)benzylamine (L²), bis(2-methylbenzimidazolyl)(2,4-dimethylphenylthioethyl)amine (L³), bis(1-methyl-2-methylbenzimidazolyl)benzylamine (Me₂L²), and bis(1-methyl-2-methylbenzimidazolyl)(2,4-dimethylphenylthioethyl)amine (Me₂L³) were spectroscopically, structurally, and electrochem. characterized. The thioether-containing ligands L³ and Me₂L³ give rise to complexes with Cu-S bonds in solution and in the solid state, as evidenced by UV-visible spectroscopy and x-ray crystallog. The Cu²⁺ complexes [L¹CuCl₂] (1), [L²CuCl₂] (2) and [Me₂L³CuCl]ClO₄ (3^Me,ClO4) are monomeric in solution according to ESI mass spectrometry data, as well as in the solid state. Their Cu⁺ analogs [L¹Cu]ClO₄, [L²Cu]ClO₄, [L³Cu]ClO₄ (4–6), [BOC₂L¹Cu(NCCH₃)]ClO₄ (4^BOC), [Me₂L²Cu(NCCH₃)₂]PF₆ (5^Me) and [Me₂L³Cu]₂(ClO₄)₂ (6^Me) are also monomeric in MeCN solution, as confirmed crystallog. for 4^BOC and 5^Me. In contrast, 6^Me is dimeric in the solid state, with the thioether group of one of the ligands bound to a symmetry-related Cu⁺ ion. Cyclic voltammetry studies revealed that the bis(2-methylbenzimidazolyl)amine-Cu²⁺/Cu⁺ systems possess half-wave potentials in the range -0.16 to -0.08 V (referenced to the ferrocenium-ferrocene couple); these values are nearly 0.23 V less neg. than those reported for related bis(picolyl)amine-derived ligands. Based on these observations, the N₃ or N₃S donor set of the benzimidazole-derived ligands is analogous to previously reported chelating systems, but the electronic environment they provide is unique, and may have relevance to histidine and methionine-containing metalloenzymes. This is also reflected in the reactivity of [Me₂L²Cu(NCCH₃)₂]⁺ (5^Me) and [Me₂L³Cu]⁺ (6^Me) towards dioxygen, which gave the superoxide anion in both cases. The thioether-bound Cu⁺ center in 6^Me appears to be more selective in the generation of O₂√^– than 5^Me, lending evidence to the hypothesis of the modulating properties of thioether ligands in Cu-O₂ reactions.

Dalton Transactions published new progress about 4760-35-4. 4760-35-4 belongs to imidazoles-derivatives, auxiliary class Chloride,Benzimidazole, name is 2-(Chloromethyl)-1-methyl-1H-benzo[d]imidazole, and the molecular formula is C9H9ClN2, Formula: C9H9ClN2.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Kuwata, Takahiro published the artcileMolecularly Imprinted Polymer Arrays as Synthetic Protein Chips Prepared by Transcription-type Molecular Imprinting by Use of Protein-Immobilized Dots as Stamps, Formula: C18H34N4O5S, the publication is Analytical Chemistry (Washington, DC, United States) (2015), 87(23), 11784-11791, database is CAplus and MEDLINE.

Molecularly imprinted polymer (MIP) arrays were demonstrated for the recognition of proteins. They were prepared via transcription-type mol. imprinting where patterned dots composed of biotinylated nanoparticles were first immobilized on a glass substrate followed by the immobilization of versatile biotinylated proteins via avidin-biotin interactions, yielding a multiple protein-immobilized stamp as a mold that could be transcribed. MIPs were prepared between the stamp and a methacrylated glass substrate, and after the stamp was peeled off, MIP dots were able to be prepared on the methacrylated glass substrate according to the positions of the immobilized proteins on the stamp. We confirmed that the prepared MIP array showed the expected selective binding toward the corresponding template proteins by conducting competitive binding assays using the fluorescently labeled proteins as corresponding competitors. The binding behaviors were consistent with those obtained by a surface plasmon resonance sensing system. We believe that the proposed platform involving the easily handled nanoparticle-based protein stamps for the preparation of MIP arrays can provide a new type of pattern recognition-based protein chip, which can be adopted as a substitute for the use of conventional protein arrays in various research and industrial fields in the life sciences.

Analytical Chemistry (Washington, DC, United States) published new progress about 359860-27-8. 359860-27-8 belongs to imidazoles-derivatives, auxiliary class Other Aliphatic Heterocyclic,Chiral,Amine,Amide,Ether,Inhibitor, name is N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide, and the molecular formula is C18H34N4O5S, Formula: C18H34N4O5S.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Scattolin, Thomas published the artcileUsing sodium acetate for the synthesis of [Au(NHC)X] complexes, HPLC of Formula: 258278-25-0, the publication is Dalton Transactions (2020), 49(28), 9694-9700, database is CAplus and MEDLINE.

The role of sodium acetate in the synthesis of [Au(NHC)Cl] complexes was examined The use of this base was also investigated for the activation of C-H and S-H bonds by exptl. and computational methods. The synthetic use of NaOAc to assemble these complexes is applicable to a wide range of NHCs and proceeds under air, under mild conditions and using tech. grade green solvents.

Dalton Transactions published new progress about 258278-25-0. 258278-25-0 belongs to imidazoles-derivatives, auxiliary class Achiral NHCs Ligands, name is 1,3-Bis(2,6-diisopropylphenyl)-4,5-dihydro-1H-imidazol-3-ium chloride, and the molecular formula is C27H39ClN2, HPLC of Formula: 258278-25-0.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem