Month: December 2022

Rutkowska, Anna published the artcileA Modular Probe Strategy for Drug Localization, Target Identification and Target Occupancy Measurement on Single Cell Level, Category: imidazoles-derivatives, the publication is ACS Chemical Biology (2016), 11(9), 2541-2550, database is CAplus and MEDLINE.

Late stage failures of candidate drug mols. are frequently caused by off-target effects or inefficient target engagement in vivo. In order to address these fundamental challenges in drug discovery, we developed a modular probe strategy based on bioorthogonal chem. that enables the attachment of multiple reporters to the same probe in cell extracts and live cells. In a systematic evaluation, we identified the inverse electron demand Diels-Alder reaction between trans-cyclooctene labeled probe mols. and tetrazine-tagged reporters to be the most efficient bioorthogonal reaction for this strategy. Bioorthogonal biotinylation of the probe allows the identification of drug targets in a chemoproteomics competition binding assay using quant. mass spectrometry. Attachment of a fluorescent reporter enables monitoring of spatial localization of probes as well as drug-target colocalization studies. Finally, direct target occupancy of unlabeled drugs can be determined at single cell resolution by competitive binding with fluorescently labeled probe mols. The feasibility of the modular probe strategy is demonstrated with noncovalent PARP inhibitors.

ACS Chemical Biology published new progress about 359860-27-8. 359860-27-8 belongs to imidazoles-derivatives, auxiliary class Other Aliphatic Heterocyclic,Chiral,Amine,Amide,Ether,Inhibitor, name is N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide, and the molecular formula is C18H34N4O5S, Category: imidazoles-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Rosepriya, S. published the artcile1,2-Diphenyl-1H-benzimidazole, COA of Formula: C19H14N2, the publication is Acta Crystallographica, Section E: Structure Reports Online (2012), 68(12), o3283, database is CAplus and MEDLINE.

In the title mol., C₁₉H₁₄N₂, the benzimidazole unit is close to being planar [maximum deviation = 0.0102(6) Å] and forms dihedral angles of 55.80(2) and 40.67(3)° with the adjacent Ph rings; the dihedral angle between the Ph rings is 62.37(3)°. In the crystal, one C-H···N H bond and three weak C-H···π interactions involving the fused benzene ring and the imidazole ring are observed, leading to a three-dimensional architecture. Crystallog. data and at. coordinates are given.

Acta Crystallographica, Section E: Structure Reports Online published new progress about 2622-67-5. 2622-67-5 belongs to imidazoles-derivatives, auxiliary class Benzimidazole,Benzene,Benzimidazole, name is 1,2-Diphenyl-1H-benzo[d]imidazole, and the molecular formula is C19H14N2, COA of Formula: C19H14N2.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Jayabharathi, J. published the artcileOptical properties of 1,2-diaryl benzimidazole derivatives – A combined experimental and theoretical studies, Recommanded Product: 1,2-Diphenyl-1H-benzo[d]imidazole, the publication is Spectrochimica Acta, Part A: Molecular and Biomolecular Spectroscopy (2013), 74-78, database is CAplus and MEDLINE.

Some novel 1,2-diaryl benzimidazole derivatives were designed, synthesized and characterized by mass, ¹H, ¹³C-NMR spectral studies and single crystal XRD. The charge distribution was calculated from the at. charges by nonlinear optical (NLO) and natural bond orbital (NBO) analyses based on DFT-B3LYP method. Synthesized 1,2-diaryl benzimidazole derivatives have the largest μ_gβ₀ value and can be used as potential NLO materials. Anal. of the mol. electrostatic potential (MEP) energy surface exploited the region for non-covalent interactions in the mol. Calculated bond lengths, bond angles and dihedral angles are found to be slightly higher than that of X-ray diffraction values of its exptl. datas.

Spectrochimica Acta, Part A: Molecular and Biomolecular Spectroscopy published new progress about 2622-67-5. 2622-67-5 belongs to imidazoles-derivatives, auxiliary class Benzimidazole,Benzene,Benzimidazole, name is 1,2-Diphenyl-1H-benzo[d]imidazole, and the molecular formula is C19H14N2, Recommanded Product: 1,2-Diphenyl-1H-benzo[d]imidazole.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Jayabharathi, J. published the artcileSynthesis of some fluorescent benzimidazole derivatives using cobalt(II) hydroxide as highly efficient catalyst – spectral and physico-chemical studies and ESIPT process, Application of 1,2-Diphenyl-1H-benzo[d]imidazole, the publication is Photochemical & Photobiological Sciences (2013), 12(10), 1761-1773, database is CAplus and MEDLINE.

Some fluorescent benzimidazole derivatives have been designed and synthesized using cobalt(II) hydroxide as highly efficient catalyst. Synthesized compounds have been characterized by ¹H and ¹³C-NMR and mass spectral anal. The solvent effect on the absorption and fluorescence bands has been analyzed and supplemented by computational studies. Solvatochromic effects on the spectral position and profile of the stationary fluorescence spectra clearly indicate the charge transfer (CT) character of the emitting singlet states of all of the compounds studied in both polar and non-polar environments. The fluorescence decays for the benzimidazoles fit satisfactorily to a single exponential kinetics. HOMO and LUMO orbital pictures [DFT/B3LYP/6-31G(d,p)] evidence the existence of excited state intramol. proton transfer (ESIPT) in benzimidazole derivatives containing a hydroxy group.

Photochemical & Photobiological Sciences published new progress about 2622-67-5. 2622-67-5 belongs to imidazoles-derivatives, auxiliary class Benzimidazole,Benzene,Benzimidazole, name is 1,2-Diphenyl-1H-benzo[d]imidazole, and the molecular formula is C19H14N2, Application of 1,2-Diphenyl-1H-benzo[d]imidazole.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Housman, Seth T. published the artcilePhysical compatibility of telavancin hydrochloride with select i.v. drugs during simulated Y-site administration, Related Products of imidazoles-derivatives, the publication is American Journal of Health-System Pharmacy (2011), 68(23), 2265-2270, database is CAplus and MEDLINE.

The phys. compatibility of telavancin with select i.v. drugs during simulated Y-site administration was evaluated. Telavancin for injection was reconstituted according to manufacturer’s recommendations and diluted with 0.9% sodium chloride injection, 5% dextrose injection, or lactated Ringer’s injection to a concentration of 7.5 mg/mL. A Y site was simulated in culture tubes by mixing 5 mL of telavancin solution with 5 mL of a tested drug solution and then switching the order of drug mixing. All mixtures were prepared in duplicate and stored at room temperature Solutions were inspected for visual, turbidity, and pH changes immediately after preparation and 15, 60, and 120 min after preparation Of the 52 drugs tested, telavancin was phys. compatible with 39 drugs in all test solutions Telavancin was incompatible with amphotericin B deoxycholate, liposomal amphotericin B, digoxin, esomeprazole sodium, furosemide, levofloxacin, and micafungin sodium in all diluents. Colistimethate sodium, cyclosporine, heparin sodium, imipenem-cilastatin sodium, methylprednisolone sodium succinate, and propofol were incompatible with telavancin in specific diluents. Incompatibilities included precipitation, pos. Tyndall beam test, and increases in turbidity. There were no substantial changes in pH over the 120-min study period. Telavancin 7.5 mg/mL in 0.9% sodium chloride injection, 5% dextrose injection, and lactated Ringer’s injection was found to be phys. compatible for 120 min at room temperature with 39 of the 52 drugs tested during simulated Y-site administration. Seven drugs were incompatible in all diluents, and 6 were incompatible in at least one diluent.

American Journal of Health-System Pharmacy published new progress about 161796-78-7. 161796-78-7 belongs to imidazoles-derivatives, auxiliary class Membrane Transporter/Ion Channel,Proton Pump, name is Sodium (S)-6-methoxy-2-(((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide, and the molecular formula is C17H18N3NaO3S, Related Products of imidazoles-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Cheng, Jing published the artcileInfluence of lactitol and psyllium on bowel function in constipated Indian volunteers: a randomized, controlled trial, COA of Formula: C17H18N3NaO3S, the publication is Nutrients (2019), 11(5), 1130, database is CAplus and MEDLINE.

Psyllium and lactitol have been reported to increase fecal volume, moisture content and bowel movement frequency (BMF). However, the benefits of their combined use on constipation has not been examined The aim of this study was to evaluate the effects of a 4-wk intervention with lactitol and/or psyllium on bowel function in constipated volunteers. Adults (N = 172) who were diagnosed with functional constipation per Rome III criteria were randomized to four treatment groups: 10 g lactitol, 3.5 g psyllium, a combination of 10 g lactitol and 3.5 g psyllium, or placebo. The primary endpoint was change in BMF from Day 0 to 28 as compared to placebo. Secondary endpoints were assessed by inventories, including stool consistency, patient assessment of constipation symptoms and quality of life, relief of constipation, 24-h food recall, phys. activity, product satisfaction and adverse events (AE). BMF increased by 3.0 BMs with lactitol, by 2.9 with psyllium, and by 3.1 with the combination, but was not different from placebo (3.7 BMs). Other clin. endpoints were similar between treatments. No serious AEs were reported. In conclusion, this study showed a similar effect on relief of constipation in all treatment groups. The treatments that were administered to the volunteers were well tolerated.

Nutrients published new progress about 161796-78-7. 161796-78-7 belongs to imidazoles-derivatives, auxiliary class Membrane Transporter/Ion Channel,Proton Pump, name is Sodium (S)-6-methoxy-2-(((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide, and the molecular formula is C17H18N3NaO3S, COA of Formula: C17H18N3NaO3S.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Wu, Wenqin published the artcileIron-Catalyzed Cross-Coupling Reactions of Arylmagnesium Reagents with Aryl Chlorides and Tosylates: Influence of Ligand Structural Parameters and Identification of a General N-Heterocyclic Carbene Ligand, Application of 1,3-Bis(2,6-diisopropylphenyl)-4,5-dihydro-1H-imidazol-3-ium chloride, the publication is Organometallics (2017), 36(12), 2293-2297, database is CAplus.

A systematic evaluation of N-heterocyclic carbene ligands in the Fe-catalyzed cross-coupling reactions of aryl chlorides and arylmagnesium reagents was performed. There is no clear correlation between the donor strength of the N-heterocyclic carbene and the reaction outcome. Instead, the highest yields of the desired biaryl product were obtained with sterically demanding ligands possessing large %V_bur values. Through this study, 1,3-bis[2,7-di(isopropyl)-1-naphthalenyl]-2-imidazolidinylidene (SIPrNap) was identified as an efficient and general ligand for the coupling of both aryl chlorides and tosylates.

Organometallics published new progress about 258278-25-0. 258278-25-0 belongs to imidazoles-derivatives, auxiliary class Achiral NHCs Ligands, name is 1,3-Bis(2,6-diisopropylphenyl)-4,5-dihydro-1H-imidazol-3-ium chloride, and the molecular formula is C5H8N2O, Application of 1,3-Bis(2,6-diisopropylphenyl)-4,5-dihydro-1H-imidazol-3-ium chloride.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Amer, M. M. published the artcileColorimetric determination of antazoline in pharmaceutical preparations with sodium nitrite, COA of Formula: C17H20ClN3, the publication is Analyst (Cambridge, United Kingdom) (1974), 99(1181), 487-90, database is CAplus and MEDLINE.

Pharmaceutical preparations containing antazoline-HCl [2508-72-7] were analyzed by solution in aqueous HCl and addition of NaNO2 solution at <10°, giving a yellow color which was stabilized by the addition of iso-PrOH, and solution absorbance determined at 410 nm. Beer’s law was obeyed between 20-120 μg of antazoline-HCl and 20-140 μg of the methanesulfonate [3131-32-6].

Analyst (Cambridge, United Kingdom) published new progress about 2508-72-7. 2508-72-7 belongs to imidazoles-derivatives, auxiliary class Inhibitor,Immunology/Inflammation,Histamine Receptor, name is N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride, and the molecular formula is C17H20ClN3, COA of Formula: C17H20ClN3.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Amer, M. M. published the artcileColorimetric determination of antazoline, Formula: C17H20ClN3, the publication is Australian Journal of Pharmaceutical Sciences (1974), 3(2), 58-60, database is CAplus.

The color reaction between antazoline-HCl (I) [2508-72-7] and Ce(SO4)2 yielded maximum absorption at 500 nm, and was used in the anal. of I in pharmaceutical preparations Fifty mg I in a final concentration of 50% H2SO4 and 2 mg ceric ammonium sulfate reached maximum intensity in 10 min and remained stable for an addnl. 30 min when kept cool. The color followed Beer’s Law at concentrations of 2-10 μgm/ml, and was due to the oxidation of I.

Australian Journal of Pharmaceutical Sciences published new progress about 2508-72-7. 2508-72-7 belongs to imidazoles-derivatives, auxiliary class Inhibitor,Immunology/Inflammation,Histamine Receptor, name is N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride, and the molecular formula is C17H20ClN3, Formula: C17H20ClN3.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Amer, M. M. published the artcileModified nitroprusside colorimetric determination of antazoline salts in some pharmaceutical preparation, Safety of N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride, the publication is Pharmazie (1974), 29(5), 354-5, database is CAplus and MEDLINE.

The nitroprusside method of Slack and Mader (1957) was improved by using 80 mg H3BO3 in place of NaHCO3 (to alter pH) and adding 4 ml EtOH to give a red color instead of the violet, measurable at 540 nm, the color being maximum at 1 min and stable for 12 hr. The method is superior to that of BP 1968 and USP XV, since ephedrine and 19 other substances tested did not interfere with the reaction but naphazoline, Zn2+, and phentolamine did,. Recovery by this method ranged between 100.6.+-.0.23% to 102.3.+-.1.2%. Determinations were made against a standard curve for 0.1-1. mg of the corresponding antazoline salt.

Pharmazie published new progress about 2508-72-7. 2508-72-7 belongs to imidazoles-derivatives, auxiliary class Inhibitor,Immunology/Inflammation,Histamine Receptor, name is N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride, and the molecular formula is C17H20ClN3, Safety of N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem