Month: December 2022

Ebisu, Keitaro published the artcileN-Terminal Specific Point-Immobilization of Active Proteins by the One-Pot NEXT-A Method, Quality Control of 359860-27-8, the publication is ChemBioChem (2009), 10(15), 2460-2464, database is CAplus and MEDLINE.

The authors earlier combined L/F-transferase-mediated functionalization with tRNA-aminoacylation using engineered aminoacyl-tRNA synthetase (ARS) in the same test tube and named the whole method NEXT-A (N-terminal extension of protein by transferase and aminoacyl-tRNA synthetase). Here, the authors report a practical method that combines the NEXT-A reaction and noncatalytic 1,3-dipolar cycloaddition for immobilizing any kind of active protein onto supports with an ordered orientation. Typically, a sugar-binding protein (lectin EW29Ch) was successfully immobilized onto an acrylamide-based gel. The authors monitored stoichiometry of the reaction during the immobilization. The lectin-immobilized gel was subjected to frontal affinity chromatog. and sugar-lectin interactions on the gel were measured. Direct immobilization of a target protein in a cell lysate without purification was also demonstrated.

ChemBioChem published new progress about 359860-27-8. 359860-27-8 belongs to imidazoles-derivatives, auxiliary class Other Aliphatic Heterocyclic,Chiral,Amine,Amide,Ether,Inhibitor, name is N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide, and the molecular formula is C18H34N4O5S, Quality Control of 359860-27-8.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Hu, Xiao published the artcileDetermination of S-omeprazole sodium and the related substances by RP-HPLC, Product Details of C17H18N3NaO3S, the publication is Zhongguo Yaofang (2009), 20(22), 1744-1746, database is CAplus.

The aim of this paper is to establish an RP-HPLC method for content determination of S-omeprazole sodium and its related substances. The separation of S-omeprazole sodium and the related substances was carried out on a Phenomenex Luna C₁V8 column, and the mobile phase consisted of methanol-0.033 mol/L^-1 ammonium dihydrogen phosphate-triethylamine. The detection wavelength was 302 nm, the flow rate was 1.0 mL/min^-1, the column temperature was 25°, and the sample size was 20 μL. The linear range of omeprazole sodium was 10-500 mg/L^-1 (r = 0.9997). The average recovery rate was 100.27% (RSD = 0.74%). The average content of the related substances in samples was 0.42%. This method is simple, accurate, specific, and applicable for content determination of S-omeprazole sodium and its related substances.

Zhongguo Yaofang published new progress about 161796-78-7. 161796-78-7 belongs to imidazoles-derivatives, auxiliary class Membrane Transporter/Ion Channel,Proton Pump, name is Sodium (S)-6-methoxy-2-(((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide, and the molecular formula is C17H18N3NaO3S, Product Details of C17H18N3NaO3S.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Liu, Wenbo published the artcileCu₂O-Catalyzed Conversion of Benzyl Alcohols Into Aromatic Nitriles via the Complete Cleavage of the C≡N Triple Bond in the Cyanide Anion, Name: 1,3-Bis(2,6-diisopropylphenyl)-4,5-dihydro-1H-imidazol-3-ium chloride, the publication is Chemistry – An Asian Journal (2021), 16(21), 3509-3513, database is CAplus and MEDLINE.

Nitrogen transfer from cyanide anion to an aldehyde is emerging as a promising method for the synthesis of aromatic nitriles. However, this method still suffers from a disadvantage that a use of stoichiometric Cu(II) or Cu(I) salts is required to enable the reaction. As authors report herein, overcame this drawback and developed a catalytic method for nitrogen transfer from cyanide anion to an alc. via the complete cleavage of the C≡N triple bond using phen/Cu₂O as the catalyst. The present condition allowed a series of benzyl alcs. to be smoothly converted into aromatic nitriles in moderate to high yields. In addition, the present method could be extended to the conversion of cinnamic alc. to 3-phenylacrylonitrile.

Chemistry – An Asian Journal published new progress about 258278-25-0. 258278-25-0 belongs to imidazoles-derivatives, auxiliary class Achiral NHCs Ligands, name is 1,3-Bis(2,6-diisopropylphenyl)-4,5-dihydro-1H-imidazol-3-ium chloride, and the molecular formula is C27H39ClN2, Name: 1,3-Bis(2,6-diisopropylphenyl)-4,5-dihydro-1H-imidazol-3-ium chloride.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Khristova, M. published the artcileDetermination of naphazoline hydrochloride in the presence of antazoline hydrochloride, Application of N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride, the publication is Farmatsiya (Sofia, Bulgaria) (1980), 30(6), 18-20, database is CAplus.

Naphazoline-HCl (I-HCl) [550-99-2] was determined in the presence of antazoline-HCl [2508-72-7] by mixing with H₂CO-H₂SO₄, extracting the colored product with CHCl₃ to remove the interference of SO₄^2-, and measuring the absorbance at 665 nm. Absorbance was linear with concentration for 20-100 μg/mL, and the error was 4.8%.

Farmatsiya (Sofia, Bulgaria) published new progress about 2508-72-7. 2508-72-7 belongs to imidazoles-derivatives, auxiliary class Inhibitor,Immunology/Inflammation,Histamine Receptor, name is N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride, and the molecular formula is C17H20ClN3, Application of N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Ang, Chee Wei published the artcileAntitubercular and Antiparasitic 2-Nitroimidazopyrazinones with Improved Potency and Solubility, Category: imidazoles-derivatives, the publication is Journal of Medicinal Chemistry (2020), 63(24), 15726-15751, database is CAplus and MEDLINE.

Following the approval of delamanid and pretomanid as new drugs to treat drug-resistant tuberculosis, there is now a renewed interest in bicyclic nitroimidazole scaffolds as a source of therapeutics against infectious diseases. We recently described a nitroimidazopyrazinone bicyclic subclass with promising antitubercular and antiparasitic activity, prompting addnl. efforts to generate analogs with improved solubility and enhanced potency. The key pendant aryl substituent was modified by (i) introducing polar functionality to the methylene linker, (ii) replacing the terminal Ph group with less lipophilic heterocycles, or (iii) generating extended biaryl side chains. Improved antitubercular and antitrypanosomal activity was observed with the biaryl side chains, with most analogs achieved 2- to 175-fold higher activity than the monoaryl parent compounds, with encouraging improvements in solubility when pyridyl groups were incorporated. This study has contributed to understanding the existing structure-activity relationship (SAR) of the nitroimidazopyrazinone scaffold against a panel of disease-causing organisms to support future lead optimization.

Journal of Medicinal Chemistry published new progress about 4760-35-4. 4760-35-4 belongs to imidazoles-derivatives, auxiliary class Chloride,Benzimidazole, name is 2-(Chloromethyl)-1-methyl-1H-benzo[d]imidazole, and the molecular formula is C9H9ClN2, Category: imidazoles-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Agata, Ryosuke published the artcileIron-catalyzed cross coupling of aryl chlorides with alkyl grignard reagents: synthetic scope and Fe(II)/Fe(IV) mechanism supported by X-ray absorption spectroscopy and density functional theory calculations, Recommanded Product: 1,3-Bis(2,6-diisopropylphenyl)-4,5-dihydro-1H-imidazol-3-ium chloride, the publication is Bulletin of the Chemical Society of Japan (2019), 92(2), 381-390, database is CAplus.

A combination of Fe(III) fluoride and 1,3-bis(2,6-diisopropylphenyl)imidazolin-2-ylidene (SIPr) catalyzes the high-yielding cross coupling of an electron-rich aryl chloride with an alkyl Grignard reagent, which cannot be attained using other Fe catalysts. A variety of alkoxy- or amino-substituted aryl chlorides can be cross-coupled with various alkyl Grignard reagents regardless of the presence or absence of β-hydrogens in the alkyl group. A radical probe experiment using 1-(but-3-enyl)-2-chlorobenzene does not afford the corresponding cyclization product, therefore excluding the intermediacy of radical species. Solution-phase x-ray absorption spectroscopy (XAS) anal., with the help of d. functional theory (DFT) calculations, indicates the formation of a high-spin (S = 2) heteroleptic difluorido organoferrate(II), [MgX][Fe(II)F₂(SIPr)(Me/alkyl)], in the reaction mixture DFT calculations also support a feasible reaction pathway, including the formation of a difluorido organoferrate(II) intermediate which undergoes a novel Lewis acid-assisted oxidative addition to form a neutral organoiron(IV) intermediate, which leads to an Fe(II)/Fe(IV) catalytic cycle, where the fluorido ligand and the Mg ion play key roles.

Bulletin of the Chemical Society of Japan published new progress about 258278-25-0. 258278-25-0 belongs to imidazoles-derivatives, auxiliary class Achiral NHCs Ligands, name is 1,3-Bis(2,6-diisopropylphenyl)-4,5-dihydro-1H-imidazol-3-ium chloride, and the molecular formula is C27H39ClN2, Recommanded Product: 1,3-Bis(2,6-diisopropylphenyl)-4,5-dihydro-1H-imidazol-3-ium chloride.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Fujiwara, Tomoyuki published the artcilePigment formation by ultraviolet-ray decomposition of histidine, Recommanded Product: (2-Methyl-1H-imidazol-4-yl)methanol, the publication is Nagasaki Igakkai Zasshi (1954), 726-30, database is CAplus.

Histidine (I), histamine, imidazoleacetic acid, 4(5)-hydroxymethylimidazole, and 2-methyl-4(5)-hydroxymethyl-imidazole (II) (2 mg. of each compound in 5 ml. of 4% Na₂-CO₃ solution) were irradiated for 2 hrs. by ultraviolet rays. All except II gave rise to pigment. When I is irradiated, a compound which reacts with Folin-Ciocalteu reagent is formed. Thus, pigment appears to be a polymerized 2-hydroxyimidazole.

Nagasaki Igakkai Zasshi published new progress about 45533-87-7. 45533-87-7 belongs to imidazoles-derivatives, auxiliary class Imidazole,Alcohol,Imidazole, name is (2-Methyl-1H-imidazol-4-yl)methanol, and the molecular formula is C5H8N2O, Recommanded Product: (2-Methyl-1H-imidazol-4-yl)methanol.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Nishizawa, Akihiro published the artcileNickel-Catalyzed Decarboxylation of Aryl Carbamates for Converting Phenols into Aromatic Amines, Recommanded Product: 1,3-Bis(2,6-diisopropylphenyl)-4,5-dihydro-1H-imidazol-3-ium chloride, the publication is Journal of the American Chemical Society (2019), 141(18), 7261-7265, database is CAplus and MEDLINE.

Herein, we describe a new catalytic approach to accessing aromatic amines from an abundant feedstock, namely phenols. The most reliable catalytic method for converting phenols to aromatic amines uses an activating group, such as a trifluoromethane sulfonyl group. However, this activating group is eliminated as a leaving group during the amination process, resulting in significant waste. Our nickel-catalyzed decarboxylation reaction of aryl carbamates forms aromatic amines with carbon dioxide as the only byproduct. As this amination proceeds in the absence of free amines, a range of functionalities, including a formyl group, are compatible. A bisphosphine ligand immobilized on a polystyrene support (PS-DPPBz) is key to the success of this reaction, generating a catalytic species that is significantly more active than simple nonsupported variants.

Journal of the American Chemical Society published new progress about 258278-25-0. 258278-25-0 belongs to imidazoles-derivatives, auxiliary class Achiral NHCs Ligands, name is 1,3-Bis(2,6-diisopropylphenyl)-4,5-dihydro-1H-imidazol-3-ium chloride, and the molecular formula is C27H39ClN2, Recommanded Product: 1,3-Bis(2,6-diisopropylphenyl)-4,5-dihydro-1H-imidazol-3-ium chloride.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Asghar, Soneela published the artcileCobalt-Catalyzed Suzuki Biaryl Coupling of Aryl Halides, Product Details of C27H39ClN2, the publication is Angewandte Chemie, International Edition (2017), 56(51), 16367-16370, database is CAplus and MEDLINE.

Readily accessed cobalt pre-catalysts with N-heterocyclic carbene ligands catalyze the Suzuki cross-coupling of aryl chlorides and bromides with alkyllithium-activated arylboronic pinacolate esters. Preliminary mechanistic studies indicate that the cobalt species is reduced to Co⁰ during the reaction.

Angewandte Chemie, International Edition published new progress about 258278-25-0. 258278-25-0 belongs to imidazoles-derivatives, auxiliary class Achiral NHCs Ligands, name is 1,3-Bis(2,6-diisopropylphenyl)-4,5-dihydro-1H-imidazol-3-ium chloride, and the molecular formula is C27H39ClN2, Product Details of C27H39ClN2.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Shreenivas, M. T. published the artcileSynthesis and antibacterial evaluation of some novel aminothiazole derivatives, Application In Synthesis of 79047-41-9, the publication is Pharma Chemica (2011), 3(2), 156-161, database is CAplus.

A series of N-(4-arylthiazol-2-yl)-4′-{[2-butyl-4-chloro-5-(hydroxymethyl)imidazol-1-yl]methyl}biphenyl-2-carboxamides was prepared The newly synthesized title compounds were screened for in-vitro antibacterial activity. Some of the compounds exhibited encouraging results.

Pharma Chemica published new progress about 79047-41-9. 79047-41-9 belongs to imidazoles-derivatives, auxiliary class Imidazole,Chloride,Alcohol, name is (2-Butyl-4-chloro-1H-imidazol-5-yl)methanol, and the molecular formula is C24H20Ge, Application In Synthesis of 79047-41-9.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem