Month: December 2022

Selvam, K. published the artcileAn easy one-step photocatalytic synthesis of 1-aryl-2-alkylbenzimidazoles by platinum loaded TiO₂ nanoparticles under UV and solar light, Application of 1,2-Diphenyl-1H-benzo[d]imidazole, the publication is Tetrahedron Letters (2011), 52(26), 3386-3392, database is CAplus.

One-pot synthesis of disubstituted benzimidazoles from N-substituted 2-nitroanilines or 1,2-diamines with 3-12 nm-sized platinum particles loaded on the TiO₂ using solar and UV-A light is described. 1-Aryl-2-alkylbenzimidazoles from 2-nitrodiphenylamines are formed by combined redox photocatalytic reaction, condensation and catalytic dehydrogenation on Pt-TiO₂. In case of diamines, this reaction is proceeded by Pt-TiO₂ assisted photocatalytic oxidation of an alc. and a catalytic dehydrogenation of the intermediate on the surface of platinum nanoparticles. In both cases product formation was achieved by tandem photocatalytic and catalytic reactions on Pt-TiO₂.

Tetrahedron Letters published new progress about 2622-67-5. 2622-67-5 belongs to imidazoles-derivatives, auxiliary class Benzimidazole,Benzene,Benzimidazole, name is 1,2-Diphenyl-1H-benzo[d]imidazole, and the molecular formula is C48H47FeP, Application of 1,2-Diphenyl-1H-benzo[d]imidazole.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Van Veller, Brett published the artcileBiocompatible post-polymerization functionalization of a water soluble poly(p-phenylene ethynylene), Recommanded Product: N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide, the publication is Chemical Communications (Cambridge, United Kingdom) (2010), 46(31), 5761-5763, database is CAplus and MEDLINE.

A biocompatible post-polymerization functionalization reaction takes advantage of a polymer’s structural motif for the controllable attachment of biotin as a model biosensor that responds to streptavidin.

Chemical Communications (Cambridge, United Kingdom) published new progress about 359860-27-8. 359860-27-8 belongs to imidazoles-derivatives, auxiliary class Other Aliphatic Heterocyclic,Chiral,Amine,Amide,Ether,Inhibitor, name is N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide, and the molecular formula is C7H8INO, Recommanded Product: N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Tulus, Rasim published the artcileSpectrophotometric determination of antihistamine drugs containing o-(benzensulfonamido)-p-benzoquinone, Recommanded Product: N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride, the publication is Journal of Faculty of Pharmacy of Istanbul University (1975), 11(2), 117-28, database is CAplus.

The treatment of a methanolic solution of some antihistamine amines, obtained from their hydrochloride, methanesulfonate, and maleate, with a methanolic solution of o-(benzenesulfonamido)-p-benzoquinone (I) [34238-55-6] afforded a red color, which was used in the spectrophotometric determination of these antihistamines.

Journal of Faculty of Pharmacy of Istanbul University published new progress about 2508-72-7. 2508-72-7 belongs to imidazoles-derivatives, auxiliary class Inhibitor,Immunology/Inflammation,Histamine Receptor, name is N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride, and the molecular formula is C24H20Ge, Recommanded Product: N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Hur, Wooyoung published the artcileA Small-Molecule Inducer of the Antioxidant Response Element, Quality Control of 359860-27-8, the publication is Chemistry & Biology (Cambridge, MA, United States) (2010), 17(5), 537-547, database is CAplus and MEDLINE.

Summary: Eukaryotic cells counteract oxidative and other environmental stress through the activation of Nrf2, the transcription factor that controls the expression of a host of protective enzymes by binding to the antioxidant response element (ARE). The electrophilic mols. that are able to activate Nrf2 and its downstream target genes have demonstrated therapeutic potential in carcinogen-induced tumor models. Using a high-throughput cellular screen, we discovered a class of ARE activator, which we named AI-1, that activates Nrf2 by covalently modifying Keap1, the neg. regulator of Nrf2. Biochem. studies indicated that modification of Cys151 of Keap1 by AI-1 disrupted the ability of Keap1 to serve as an adaptor for Cul3-Keap1 ubiquitin ligase complex, thereby causing stabilization and transcriptional activation of Nrf2. AI-1 and its biotinylated derivative are useful pharmacol. probes for investigating the mol. details of the cellular antioxidant response.

Chemistry & Biology (Cambridge, MA, United States) published new progress about 359860-27-8. 359860-27-8 belongs to imidazoles-derivatives, auxiliary class Other Aliphatic Heterocyclic,Chiral,Amine,Amide,Ether,Inhibitor, name is N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide, and the molecular formula is C18H34N4O5S, Quality Control of 359860-27-8.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Guan, Qianqian published the artcileThe synthesis of benzimidazoles via a recycled palladium catalyzed hydrogen transfer under mild conditions, Safety of 1,2-Diphenyl-1H-benzo[d]imidazole, the publication is Organic & Biomolecular Chemistry (2018), 16(12), 2088-2096, database is CAplus and MEDLINE.

An efficient synthesis of benzimidazoles I [R¹ = Me, Ph, 2-thienyl, etc.; R² = H, Me, CF₃; R³ = H, Me, Ph, 2-pyridyl, 3-Me-2-pyridyl] was developed via recycled palladium-catalyzed hydrogen-transfer reaction of N-substituted-2-nitroanilines and alcs. The reaction was carried out smoothly under mild conditions that afforded variety of benzimidazoles I with good to excellent yields. The palladium catalyst was recovered easily and reused six times with great catalytic activity.

Organic & Biomolecular Chemistry published new progress about 2622-67-5. 2622-67-5 belongs to imidazoles-derivatives, auxiliary class Benzimidazole,Benzene,Benzimidazole, name is 1,2-Diphenyl-1H-benzo[d]imidazole, and the molecular formula is C19H14N2, Safety of 1,2-Diphenyl-1H-benzo[d]imidazole.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Cao, Hongtao published the artcileIridium(III) complexes adopting 1,2-diphenyl-1H-benzoimidazole ligands for highly efficient organic light-emitting diodes with low efficiency roll-off and non-doped feature, SDS of cas: 2622-67-5, the publication is Journal of Materials Chemistry C: Materials for Optical and Electronic Devices (2014), 2(12), 2150-2159, database is CAplus.

Two novel Ir(III) complexes (pbi)₂Ir(mtpy) (1) and (pbi)₂Ir(pbim) (2) adopting 1,2-diphenyl-1H-benzoimidazole (Hpbi) as cyclometalated ligands were synthesized and characterized. Strong emissions at 501 and 536 nm with high luminescence quantum yields of 48 and 91% in CH₂Cl₂ at 298 K were obtained for 1 and 2, resp. The quantum chem. calculations and the photophys. properties indicated that the dominant ³MLCT (metal-to-ligand charge-transfer) state mixed with ³LLCT (ligand-to-ligand charge-transfer) and ³LC (ligand-centered ³π-π^*) characters contributed to their phosphorescence emissions. Doped organic LEDs (OLEDs) based on 1 and 2 showed a peak current efficiency of 45.0 cd A^-1 and power efficiency of 47.9 lm W^-1 accompanied by low efficiency roll-off values. In their nondoped OLEDs, high efficiencies of 24.4 cd A^-1 and 26.3 lm W^-1 were achieved. These appealing results reveal that 1 and 2 open interesting perspectives for the development of high-performance OLEDs in the future.

Journal of Materials Chemistry C: Materials for Optical and Electronic Devices published new progress about 2622-67-5. 2622-67-5 belongs to imidazoles-derivatives, auxiliary class Benzimidazole,Benzene,Benzimidazole, name is 1,2-Diphenyl-1H-benzo[d]imidazole, and the molecular formula is C19H14N2, SDS of cas: 2622-67-5.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Kowalska, Dorota published the artcileInteraction of ionic liquids with human serum albumin in the view of bioconcentration: a preliminary study, Formula: C8H15ClN2, the publication is Chemical Papers (2022), 76(4), 2405-2417, database is CAplus.

Bioaccumulation potential is critical in PBT and risk assessment of chems. However, for ionic liquids (ILs), this aspect remains neglected. It is especially important to fill this gap, because for this group of compounds, existing data confirm their risk of being environmentally persistent and toxicity. Moreover, considering preliminary reports on the interactions of ILs with lipids, it may be assumed that ILs have a higher potential for bioaccumulation than indicated by previous estimations built upon octanol-water partition coefficients Moreover, the bioconcentration of ionizable chem. compounds may also be strongly related to plasma protein contents. Therefore, in this work, the affinity of a set of imidazolium cations and organic anions, and their combination to human serum albumin (HSA) was determined The obtained results reveal that both cations and anions can be strongly bound to HSA, and blood proteins might play an important role in overall bioaccumulation. Furthermore, it was observed that HSA binding properties towards IL cations depend on the hydrophobicity of cations. The obtained data also provide indication that cation-anion interaction may affect ILs ions affinity to HSA.

Chemical Papers published new progress about 79917-90-1. 79917-90-1 belongs to imidazoles-derivatives, auxiliary class Ionic Liquid,Ionic Liquid, name is 3-Butyl-1-methyl-1H-imidazol-3-ium chloride, and the molecular formula is C8H15ClN2, Formula: C8H15ClN2.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Roberts, Fiona published the artcileThe kinetics of competitive antagonists on guinea-pig ileum, Quality Control of 2508-72-7, the publication is British Journal of Pharmacology (1976), 58(1), 57-70, database is CAplus and MEDLINE.

The kinetics of the antagonistic action of mepyramine maleate [59-33-6], atropine sulfate [55-48-1], lachesine [1164-38-1], benziloyltropine methyliodide [21735-94-4], pentyltriethyl ammonium iodide [21735-95-5], and antazoline-HCl [2508-72-7] on guinea pig isolated ileum were not consistent with the predictions of the interaction-limited model described by W. D. M. Paton (1961). The apparent dissociation rate constant calculated from the decrease in occupancy on washout was not independent of the concentration of antagonist; the dissociation rate constant of a ‘slow’ antagonist calculated from the change in occupancy when a ‘fast’ antagonist was superimposed varied with the concentration of fast antagonist; if the concentration of slow antagonist was increased when the fast antagonist was superimposed so that the equilibrium occupancy of the ‘slow’ was the same as before, a transitional phase was observed

British Journal of Pharmacology published new progress about 2508-72-7. 2508-72-7 belongs to imidazoles-derivatives, auxiliary class Inhibitor,Immunology/Inflammation,Histamine Receptor, name is N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride, and the molecular formula is C17H20ClN3, Quality Control of 2508-72-7.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

House, Donald A. published the artcileChiral heterocyclic ligands. Part V. The first x-ray structure of an octahedral transition metal complex containing a strongly chelating bidentate perchlorate, Application In Synthesis of 4760-35-4, the publication is Journal of the Chemical Society, Chemical Communications (1987), 1575-6, database is CAplus.

NiL₂(ClO₄)₂.EtOH (L = I) was prepared from Ni(ClO₄)₂.6H₂O and L in EtOH. NiL₂(ClO₄)₂.EtOH is monoclinic, space group P2₁, with a 13.370(8), b 21.152(13), c 15.605(9) Å, β 99.73(5)°, Z = 4, d.(calculated) = 1.44 g cm^-3, R = 0.063. Two different stereoisomers of [NiL₂(ClO₄)]⁺ are present in an asym. unit, each of which contains a strongly bidentate perchlorate and the bulky borane groups in a trans configuration.

Journal of the Chemical Society, Chemical Communications published new progress about 4760-35-4. 4760-35-4 belongs to imidazoles-derivatives, auxiliary class Chloride,Benzimidazole, name is 2-(Chloromethyl)-1-methyl-1H-benzo[d]imidazole, and the molecular formula is C9H9ClN2, Application In Synthesis of 4760-35-4.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Mazur, Elzbieta published the artcileEffect of histamine on tissue respiration of the cardiac muscle of rats treated with antihistaminics, Application of N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride, the publication is Annales Universitatis Mariae Curie-Sklodowska, Sectio D: Medicina (1977), 273-80, database is CAplus and MEDLINE.

Incubation of rat myocardial slices with histamine-HCl (I-HCl) [23758-34-1] decreased O consumption by up to 67% after 45 min. Similar treatment of myocardial slices from rats pretreated with Diphergan [60-87-7] (30 mg/kg/day, i.p., for 7-10 days) resulted in only 43% inhibition at the end of 45 min. Pretreatment of rats with thenalidine calcium [67250-62-8] (25 mg/kg/day) or phenazoline-HCl [2508-72-7] (100 mg/kg/day) did not alter the effect of I on myocardial respiration.

Annales Universitatis Mariae Curie-Sklodowska, Sectio D: Medicina published new progress about 2508-72-7. 2508-72-7 belongs to imidazoles-derivatives, auxiliary class Inhibitor,Immunology/Inflammation,Histamine Receptor, name is N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride, and the molecular formula is C17H20ClN3, Application of N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem