Month: December 2022

Pathak, Devender published the artcileSynthesis, characterization and antimicrobial evaluation of some newer substituted benzimidazole derivatives, SDS of cas: 4760-35-4, the publication is Journal of Chemical and Pharmaceutical Sciences (2011), 4(1), 26-29, database is CAplus.

1,2-Benzenediamine dihydrochloride when reacted with different carboxylic acid derivatives yielded 2-substituted benzimidazole derivatives [no data] which on methylation afforded 1-methyl-2-substituted benzimidazole derivatives, and on acetylation yielded 1-acetyl-2-substituted benzimidazole derivatives The synthesized compounds were elucidated by phys. and spectral data and screened for in vitro antibacterial activity against two gram pos. (Staphylococcus aureus, Bacillus subtilis) and two gram neg. bacterial strains (Pseudomonas aeruginosa, Escherichia coli) and in vitro antifungal activity against Candida albicans, Aspergillus niger.

Journal of Chemical and Pharmaceutical Sciences published new progress about 4760-35-4. 4760-35-4 belongs to imidazoles-derivatives, auxiliary class Chloride,Benzimidazole, name is 2-(Chloromethyl)-1-methyl-1H-benzo[d]imidazole, and the molecular formula is C9H9ClN2, SDS of cas: 4760-35-4.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Singh, Gagandeep published the artcileSynthesis, molecular docking, α-glucosidase inhibition, and antioxidant activity studies of novel benzimidazole derivatives, SDS of cas: 4760-35-4, the publication is Medicinal Chemistry Research (2020), 29(10), 1846-1866, database is CAplus.

A novel series of N-methyl/benzyl-substituted benzimidazolyl-linked para-substituted benzyl-based compounds containing 2,4-thiazolidinediones, di-Me malonate (DMM) and di-Et malonate (DEM) were designed, docked, synthesized, and evaluated for their antidiabetic activity studies. Four targeted compounds I (R = Me, Bn) and II showed good inhibitory potential in the range of 4.10 +/- 0.01 to 9.12 +/- 0.06μM. Furthermore, synthesized compounds were evaluated for their antioxidant potential and compared with standard ascorbic acid and results showed that compound I (R = Bn) (EC₅₀ = 0.176 +/- 0.002 mM) being the most active. Compounds I and II exhibited prominent antidiabetic as well as antioxidant activity. Compound I (R = Bn) was considered a promising candidate for this series. The designed mols. were docked into α-glucosidase protein (PDB Code. 3TOP) to develop a correlation with the α-glucosidase inhibition studies and were also addnl. docked into PPARγ proteins (PDB ID: 2PRG) with rosiglitazone (standard drug) to study their PPARγ binding affinity in comparison with rosiglitazone and to classify these compounds for their PPARγ agonistic behavior.

Medicinal Chemistry Research published new progress about 4760-35-4. 4760-35-4 belongs to imidazoles-derivatives, auxiliary class Chloride,Benzimidazole, name is 2-(Chloromethyl)-1-methyl-1H-benzo[d]imidazole, and the molecular formula is C25H29N9O3, SDS of cas: 4760-35-4.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Cruz, Thais R. published the artcileNew dmso-ruthenium catalysts bearing N-heterocyclic carbene ligands for the ring-opening metathesis of norbornene, Synthetic Route of 258278-25-0, the publication is New Journal of Chemistry (2019), 43(16), 6220-6227, database is CAplus.

Novel DMSO Ru(II) complexes of N-heterocyclic carbenes [RuCl₂(S-DMSO)₂(SIMes)] (1), [RuCl₂(S-DMSO)₂(IMes)], (2) [RuCl₂(S-DMSO)₂(SIDip)] (3), and [RuCl₂(S-DMSO)₂(IDip)] (4) were successfully synthesized. The complexes 1–4 were characterized by elemental anal., FTIR, UV-visible, ¹H and ¹³C NMR, and computational studies. The polynorbornene (polyNBE) syntheses via ROMP using the complexes 1–4 as pre-catalysts in the presence of Et diazoacetate (EDA) were evaluated under different [EDA]/[Ru] and [NBE]/[Ru] ratios, temperatures (25 and 50°) and times (5-60 min). Quant. yields of polyNBEs using [NBE]/[EDA]/[Ru] = 5000/28/1 for 10 min at 25° were obtained. The order of magnitude of 10⁵ g mol^-1 for M_n and PDI values ranging from 1.2 to 3.5 were measured by SEC. A study combining exptl. data and computational calculations was performed to elucidate the mechanism of ROMP of NBE mediated by the complexes 1–4 as pre-catalysts. The proposed mechanism suggests the occurrence of a dissociative reaction of the complexes 1–4, losing a DMSO ligand as the 1st step, resulting in a 14-electron species, which reacts with EDA to form the metal-carbene, followed by discoordination of the 2nd DMSO mol. for coordination of NBE.

New Journal of Chemistry published new progress about 258278-25-0. 258278-25-0 belongs to imidazoles-derivatives, auxiliary class Achiral NHCs Ligands, name is 1,3-Bis(2,6-diisopropylphenyl)-4,5-dihydro-1H-imidazol-3-ium chloride, and the molecular formula is C27H39ClN2, Synthetic Route of 258278-25-0.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Behravesh, Esfandiar published the artcileQuantification of ligand surface concentration of bulk-modified biomimetic hydrogels, Recommanded Product: N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide, the publication is Biomaterials (2003), 24(24), 4365-4374, database is CAplus and MEDLINE.

This study describes a method for the quantification of active ligand surface concentration for bulk-modified hydrogels. Two poly(propylene fumarate-co-ethylene glycol) (P(PF-co-EG)) block copolymers were synthesized with terminal poly(ethylene glycol) (PEG) chains of number average mol. weight 1960 and 5190 g/mol. Hydrogels were synthesized with bulk-modified biotin as a model ligand, making use of a PEG spacer arm with a mol. weight of 3400 g/mol. Bulk concentration of biotin was calculated from the initial concentration of biotin, sol fraction, equilibrium water content, and relative incorporation of the polymers to the hydrogel. Surface concentration of biotin bulk-modified hydrogels was quantified with an enzyme linked immunosorbent assay using mouse monoclonal anti-biotin antibody (IgG), horseradish peroxidase-conjugated anti-mouse IgG, and a chemiluminescent substrate. The larger size of the IgG relative to the mesh size of the hydrogels allowed for the quantification of the active biotin at the surface of the hydrogels. Luminescent imaging was used to qual. show the isolation of the horseradish peroxidase-conjugated antibodies to the surface of the bulk-modified hydrogel. The active biotin ligands at the surface of hydrogels synthesized with terminal PEG chains of 1960 g/mol were at the top 7.2 nm while for those synthesized with terminal PEG chains of 5190 g/mol were at the top 4.4 nm of the bulk-modified hydrogel. The relationship between bulk ligand concentration and the active ligand concentration at the surface was dependent on the hydrogel composition The relative magnitude of the PEG spacer arm of the ligand compared to the PEG block length of the copolymer affected the surface availability of the ligand. The results suggest that steric hindrances caused by mobile PEG chains of the copolymer of mol. weight greater than that of the PEG spacer arm contributed to the decreased surface concentration of ligand. This work relates the bulk concentration of a ligand to its surface concentration, an important parameter for the adhesion, migration, and function of anchorage dependent cells.

Biomaterials published new progress about 359860-27-8. 359860-27-8 belongs to imidazoles-derivatives, auxiliary class Other Aliphatic Heterocyclic,Chiral,Amine,Amide,Ether,Inhibitor, name is N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide, and the molecular formula is C18H34N4O5S, Recommanded Product: N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Thoma, K. published the artcileColloid association of antihistamines. Part 1. Relation between chemical structure and critical micelle formation concentration, Quality Control of 2508-72-7, the publication is Pharmaceutica Acta Helvetiae (1976), 51(3), 50-8, database is CAplus and MEDLINE.

Surface tensions were determined for 17 antihistamines in 0.5% aqueous solutions, and critical micelle concentrations ranging from 0.012 mole/l. (medrylamine maleate [60407-52-5]) to 0.185 mole/l. (Thenfadil [91-79-2]) were determined for all of these compounds and also for chlorphenamine-HCl [56343-98-7] in 0.9% saline. Cryoscopic, spectrophotometric, tensiometric, potentiometric, and conductometric methods were used to determine the critical micelle concentrations, and the results and ease of use were compared. The unsubstituted ethylenediamine, propylamine, and ethanolamine derivatives, Pyribenzamine [91-81-6], Avil [3269-83-8], and Benadryl [147-24-0], had similar critical micelle concentrations These concentrations decreased on phenyl group substitution in the order Me > Cl > Br.

Pharmaceutica Acta Helvetiae published new progress about 2508-72-7. 2508-72-7 belongs to imidazoles-derivatives, auxiliary class Inhibitor,Immunology/Inflammation,Histamine Receptor, name is N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride, and the molecular formula is C10H15ClO3S, Quality Control of 2508-72-7.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

San Andres, M. P. published the artcileDetermination of antihistamines based on the formation of mixed aggregates with surfactants, Related Products of imidazoles-derivatives, the publication is Analyst (Cambridge, United Kingdom) (1998), 123(5), 1079-1084, database is CAplus.

The determination of antihistamines based on the measurement of the critical micelle concentration (CMC) of mixed sodium dodecyl sulfate (SDS)-antihistamine aggregates is proposed. The dye Coomassie Brilliant Blue G (CBBG) was used as a photometric probe (610 nm) for the rapid determination of CMCs. The micellar properties of the drugs permitted the determination of diphenhydramine, antazoline, tripelennamine, diphenylpyraline, and clemizole at the μM level, with detection limits from 0.1 to 0.7 μM. The proposed method surpasses in sensitivity the existing routine photometric methods used in the drug quality control and has detection limits similar to fluorimetric methods. The relative standard deviation for 6 μM diphenhydramine was 3.7%. The method was applied to the determination of these drugs in pharmaceutical preparations (solutions, capsules, creams, pills) which were analyzed directly after dissolution in distilled water.

Analyst (Cambridge, United Kingdom) published new progress about 2508-72-7. 2508-72-7 belongs to imidazoles-derivatives, auxiliary class Inhibitor,Immunology/Inflammation,Histamine Receptor, name is N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride, and the molecular formula is C17H20ClN3, Related Products of imidazoles-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Li, Xiaochun published the artcileInkjet-Printed Bioassays for Direct Reading with a Multimode DVD/Blu-Ray Optical Drive, Synthetic Route of 359860-27-8, the publication is Analytical Chemistry (Washington, DC, United States) (2014), 86(18), 8922-8926, database is CAplus and MEDLINE.

Compact disk-based bioassays have been developed as novel point-of-care (POC) tools for various applications in chem. anal. and biomedical diagnosis. For the fabrication of assay disks, the surface patterning and sample introduction have been restricted to manual delivery that is unfavorable for on-demand high throughput medical screening. Herein, the authors have adapted a conventional inkjet printer to prepare bioassays on regular DVD-Rs and accomplished quant. anal. with a multimode DVD/Blu-Ray optical drive in conjunction with free disk diagnostic software. The feasibility and accuracy of this method have been demonstrated by the quant. anal. of inkjet-printed biotin-streptavidin binding assays on DVD, which serves as a trial system for other complex, medically relevant sandwich-format or competitive immunoassays.

Analytical Chemistry (Washington, DC, United States) published new progress about 359860-27-8. 359860-27-8 belongs to imidazoles-derivatives, auxiliary class Other Aliphatic Heterocyclic,Chiral,Amine,Amide,Ether,Inhibitor, name is N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide, and the molecular formula is C18H34N4O5S, Synthetic Route of 359860-27-8.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Zeng, Run-Sheng published the artcileSynthesis of 1,2-diphenyl-1H-benzimidazole derivatives by an iodobenzene diacetate-mediated reaction of N,N’-diphenylbenzamidine derivatives, Category: imidazoles-derivatives, the publication is Youji Huaxue (2008), 28(3), 476-478, database is CAplus.

1,2-Phenyl-1H-benzimidazole derivatives were prepared by the reaction of iodobenzene diacetate with N,N’-diarybenzamidine derivatives in moderate yields at room temperature with simple manipulation. All the products were confirmed by ¹H NMR, ¹³C NMR, MS and IR spectra. A possible reaction mechanism was proposed.

Youji Huaxue published new progress about 2622-67-5. 2622-67-5 belongs to imidazoles-derivatives, auxiliary class Benzimidazole,Benzene,Benzimidazole, name is 1,2-Diphenyl-1H-benzo[d]imidazole, and the molecular formula is C6H20Cl2N4, Category: imidazoles-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Elterman, V. A. published the artcileFeatures of aluminum electrodeposition from 1,3-dialkylimidazolium chloride chloroaluminate ionic liquids, Formula: C8H15ClN2, the publication is Journal of Molecular Liquids (2022), 118693, database is CAplus.

The mechanism of aluminum electrodeposition from acidic 1-butyl-3-methylimidazolium chloride chloroaluminate ionic liquids ([BMIm]Cl ILs) is studied over a wide range of the molar ratio of AlCl₃ to [BMIm]Cl (N) at 30°C. The findings for AlCl₃-[BMIm]Cl and AlCl₃-1-ethyl-3-methylimidazolium chloride ([EMIm]Cl) are analyzed and compared in order to identify dependences common for 1,3-dialkylimidazolium chloride ILs. Limiting currents were detected on the cathodic polarization curves at the aluminum | ionic liquid interface. Limiting currents are caused by the Al₂Cl^–₇ anions diffusion to the electrode surface. The limiting c.d. values for AlCl₃-[BMIm]Cl are lower (i_lim, 1.1 ≤ N leq 2.0 = 1.17 – 12.36 mA•cm^-2) than for AlCl₃-[EMIm]Cl (i_lim, 1.1 ≤ N leq 2.0 = 1.81 – 25.37 mA·cm^-2). It is shown that anion AlCl-4 can be reduced to metallic aluminum at cathodic overpotentials above 1.5 V. The diffusion coefficient of Al₂Cl-7 in AlCl₃-[BMIm]Cl (7.4•10-7 cm²•s^-1) is lower than in AlCl₃-[EMIm]Cl (9.3•10-7 cm²•s^-1) and is unaffected by aluminum chloride concentration in either system.

Journal of Molecular Liquids published new progress about 79917-90-1. 79917-90-1 belongs to imidazoles-derivatives, auxiliary class Ionic Liquid,Ionic Liquid, name is 3-Butyl-1-methyl-1H-imidazol-3-ium chloride, and the molecular formula is C8H15ClN2, Formula: C8H15ClN2.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Suter, Scott R. published the artcileStructure-Guided Control of siRNA Off-Target Effects, Recommanded Product: (2-Methyl-1H-imidazol-4-yl)methanol, the publication is Journal of the American Chemical Society (2016), 138(28), 8667-8669, database is CAplus and MEDLINE.

Short interfering RNAs (siRNAs) are promising therapeutics that make use of the RNA interference (RNAi) pathway, but liabilities arising from the native RNA structure necessitate chem. modification for drug development. Advances in the structural characterization of components of the human RNAi pathway have enabled structure-guided optimization of siRNA properties. Here the authors report the 2.3 Å resolution crystal structure of human Argonaute 2 (hAgo2), a key nuclease in the RNAi pathway, bound to an siRNA guide strand bearing an unnatural triazolyl nucleotide at position 1 (g1). Unlike natural nucleotides, this analog inserts deeply into hAgo2’s central RNA binding cleft and thus is able to modulate pairing between guide and target RNAs. The affinity of the hAgo2-siRNA complex for a seed-only matched target was significantly reduced by the triazolyl modification, while the affinity for a fully matched target was unchanged. In addition, siRNA potency for off-target repression was reduced (4-fold increase in IC₅₀) by the modification, while on-target knockdown was improved (2-fold reduction in IC₅₀). Controlling siRNA on-target vs. microRNA (miRNA)-like off-target potency by projection of substituent groups into the hAgo2 central cleft from g1 is a new approach to enhance siRNA selectivity with a strong structural rationale.

Journal of the American Chemical Society published new progress about 45533-87-7. 45533-87-7 belongs to imidazoles-derivatives, auxiliary class Imidazole,Alcohol,Imidazole, name is (2-Methyl-1H-imidazol-4-yl)methanol, and the molecular formula is C4H7BrO, Recommanded Product: (2-Methyl-1H-imidazol-4-yl)methanol.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem