Month: December 2022

Syntheses of substituted 2-(1-methyl-2-imidazolyl)quinolines was written by Khazan, Minoo;Hadizadeh, Farzin;Shafiee, Abbas. And the article was included in Journal of Heterocyclic Chemistry in 1997.Recommanded Product: 85692-37-1 This article mentions the following:

Reaction of methyllithium with 1-methyl-2-imidazolecarboxaldehyde afforded the corresponding alc. Oxidation of the alc. with manganese dioxide gave 2-acetyl-1-methylimidazole (I). I reacted with isatins to give quinoline-4-carboxylic acids, which were converted to amides, carbamates, and amines. In the experiment, the researchers used many compounds, for example, 1-(1-Methyl-1H-imidazol-2-yl)ethanone (cas: 85692-37-1Recommanded Product: 85692-37-1).

1-(1-Methyl-1H-imidazol-2-yl)ethanone (cas: 85692-37-1) belongs to imidazole derivatives. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs. Imidazole has been usedin the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein, in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography, as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells.Recommanded Product: 85692-37-1

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Gas solubility in long-chain imidazolium-based ionic liquids was written by Dai, Chengna;Lei, Zhigang;Chen, Biaohua. And the article was included in AIChE Journal in 2017.Electric Literature of C18H31F6N3O4S2 This article mentions the following:

The gas solubility in 1-dodecyl-3-methylimidazolium [C₁₂MIM] based ionic liquids (ILs) was measured at temperatures (333.2, 353.2, and 373.2) K and pressures up to 60 bar for the first time. The popular UNIFAC-Lei model was successfully extended to long-chain imidazolium-based IL and gas (CO₂, CO, and H₂) systems. The free volume theory was used to explain the gas solubility and selectivity in imidazolium-based ILs by calculating the fractional free volume and free volume by the COSMO-RS model. Furthermore, the excess enthalpy of gas-IL system was concerned to provide new insights into temperature dependency of gas (CO₂, CO, and H₂) solubility in ILs. The exptl. data, calculation, and theor. anal. presented in this work are important in gas separations with ILs or supported ionic liquid membranes. © 2017 American Institute of Chem. Engineers AIChE J, 2017. In the experiment, the researchers used many compounds, for example, 3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide (cas: 404001-48-5Electric Literature of C18H31F6N3O4S2).

3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide (cas: 404001-48-5) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. Imidazole is incorporated into many important biological compounds. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Histidine is present in many proteins and enzymes, e.g. by binding metal cofactors, as seen in hemoglobin.Electric Literature of C18H31F6N3O4S2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

4-Methyltrityl-Protected Pyrrole and Imidazole Building Blocks for Solid Phase Synthesis of DNA-Binding Polyamides was written by Heinrich, Benedikt;Vazquez, Olalla. And the article was included in Organic Letters in 2020.Recommanded Product: Methyl 1-methyl-4-nitro-1H-imidazole-2-carboxylate This article mentions the following:

DNA-binding polyamides are synthetic oligomers of pyrrole/imidazole units with high specificity and affinity for double-stranded DNA. To increase their synthetic diversity, we report a mild methodol. based on 4-methyltrityl (Mtt) solid phase peptide synthesis (SPPS), whose building blocks are more accessible than the standard Fmoc and Boc SPPS ones. We demonstrate the robustness of the approach by preparing and studying a hairpin with all precursors. Importantly, our strategy is orthogonal and compatible with sensitive mols. and could be readily automated. In the experiment, the researchers used many compounds, for example, Methyl 1-methyl-4-nitro-1H-imidazole-2-carboxylate (cas: 169770-25-6Recommanded Product: Methyl 1-methyl-4-nitro-1H-imidazole-2-carboxylate).

Methyl 1-methyl-4-nitro-1H-imidazole-2-carboxylate (cas: 169770-25-6) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.n increase of the alkyl chain length of the alcohols. Recommanded Product: Methyl 1-methyl-4-nitro-1H-imidazole-2-carboxylate

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

A Solid Alkylation: Highly Recyclable, Flow Chemistry-Ready, Resin-Supported Thioimidazoliums Alkylate Sulfur-Centered Nucleophiles was written by Cataldo, Vincenzo Alessandro;Taimoory, S. Maryamdokht;Mohammadzadeh, Sanam;Guterman, Ryan;Trant, John F.. And the article was included in European Journal of Organic Chemistry in 2022.HPLC of Formula: 1632-83-3 This article mentions the following:

A series of readily regenerable thioimidazolium-based ionic liquids, which can transfer alkyl groups to nucleophiles, are immobilized on crosslinked polystyrene beads. Different alkyl groups can be loaded onto the resin, highlighting the tunability of the material. The efficiency of these materials is demonstrated by their screening against a series of nucleophiles, showing a particular preference for thiols. Finally, these materials were evaluated for use under continuous flow conditions. The flexibility, ease of use, safety, and recyclability of these alkylating resins shows promise for their use in large scale and automated applications. In the experiment, the researchers used many compounds, for example, 1-Methylbenzimidazole (cas: 1632-83-3HPLC of Formula: 1632-83-3).

1-Methylbenzimidazole (cas: 1632-83-3) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. Imidazole is incorporated into many important biological compounds. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Histidine is present in many proteins and enzymes, e.g. by binding metal cofactors, as seen in hemoglobin.HPLC of Formula: 1632-83-3

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Visible-light-induced aerobic oxidative desulfurization of 2-mercaptobenzimidazoles via a sulfinyl radical was written by Fu, Mei;Ji, Xiaochen;Li, Yongtong;Deng, Guo-Jun;Huang, Huawen. And the article was included in Green Chemistry in 2020.Name: 1-Methylbenzimidazole This article mentions the following:

A mild transition-metal-free non-toxic aerobic photoredox system was found to enable highly efficient desulfurization of 2-mercaptobenzimidazoles I [R = H, Me; R¹ = H, Ph, but-3-en-1-yl, (2-(trimethylsilyl)ethoxy)methyl, etc.; R² = H, OMe, Cl, t-Bu, etc.; R³ = H, F, Cl, Br, Me; R²R³ = -CH=CH-CH=CH-; X = SH] and 6-methoxy-3H-imidazo[4,5-b]pyridine-2-thiol, 1H-Imidazo[4,5-b]phenazine-2-thiol. This viable catalytic system includes Rose Bengal in a low catalyst loading as a photosensitizer and cheap, non-toxic NaCl in a catalytic amount as an additive, combined with an oxygen atm. This protocol provides an important alternative access to a broad range of benzimidazoles I (X = H) and 6-methoxy-3H-imidazo[4,5-b]pyridine, 1H-imidazo[4,5-b]phenazine/deuterated benzimidazoles e.g., I (X = D) and 6-methoxy-3H-imidazo[4,5-b]pyridine-2-d product in generally high yields with good tolerance of various synthetically and pharmaceutically useful functionalities. The mechanistic studies reveal that both single electron transfer and energy transfer probably occur in the initial step and a sulfinyl radical intermediate is involved in the key desulfurization process. In the experiment, the researchers used many compounds, for example, 1-Methylbenzimidazole (cas: 1632-83-3Name: 1-Methylbenzimidazole).

1-Methylbenzimidazole (cas: 1632-83-3) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Many drugs contain an imidazole ring, such as certain antifungal drugs, the nitroimidazole series of antibiotics, and the sedative midazolam.Name: 1-Methylbenzimidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Didehydrohetarenes. XX. Reactions of 4- and 5-haloimidazoles with lithium piperidide in piperidine was written by De Bie, D. A.;Van Der Plas, H. C.;Geurtsen, G.. And the article was included in Recueil des Travaux Chimiques des Pays-Bas in 1971.Application In Synthesis of 4-Bromo-1-methylimidazole This article mentions the following:

On treatment of 5-halo-1-methyl-imidazole with lithium piperidide in piperidine, an addition-elimination reaction giving 1-methyl-5-piperidinoimidazole, transhalogenation giving 4-halo-1-methylimidazole and a meta substitution yielding the 1-methyl-2-piperidinoimidazole, were observed. No indication for the occurrence of a 4,5-didehydro-1-methylimidazole was obtained. In the experiment, the researchers used many compounds, for example, 4-Bromo-1-methylimidazole (cas: 25676-75-9Application In Synthesis of 4-Bromo-1-methylimidazole).

4-Bromo-1-methylimidazole (cas: 25676-75-9) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. Many drugs contain an imidazole ring, such as certain antifungal drugs, the nitroimidazole series of antibiotics, and the sedative midazolam.Application In Synthesis of 4-Bromo-1-methylimidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Imidazolium-type ionic liquid-based carbon quantum dot doped gels for information encryption was written by Wu, Yiqing;Ren, Yongyuan;Guo, Jiangna;Liu, Ziyang;Liu, Lili;Yan, Feng. And the article was included in Nanoscale in 2020.Safety of 1-Octyl-1H-imidazole This article mentions the following:

Here, a strategy for the preparation of adjustable imidazolium-type ionic liquid (IL)-based carbon quantum dots (CQDs) was reported. The effect of chem. structure, including carbon chain length of the N-substitution and the type of anion, on the amphiphilicity of CQDs was systematically investigated. It was found that the hydrophobicity of CQDs can be increased with the increase of carbon chain length for substitution at the N3 position. Moreover, the amphiphilicity of CQDs was also switched by changing the hydrophilic anions to hydrophobic anions. Due to adjustable amphiphilicity, the hydrophilic and hydrophobic CQDs were used for the preparation of fluorescent hydrogels and organogels, resp. The fluorescent CQD-doped gels showed light- and force-dual stimuli responsiveness, which provides more secure information encryption than traditional single encryption inks. In the experiment, the researchers used many compounds, for example, 1-Octyl-1H-imidazole (cas: 21252-69-7Safety of 1-Octyl-1H-imidazole).

1-Octyl-1H-imidazole (cas: 21252-69-7) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with a Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).Safety of 1-Octyl-1H-imidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Facile grafting of ionic liquids onto halloysite nanotubes via an atom transfer radical polymerization method was written by Qin, Xinying;Guo, Ziyang;Wang, Chao;Song, Meining;Zhang, Hailei;Wu, Yonggang. And the article was included in Journal of Polymer Materials in 2018.COA of Formula: C9H15F6N2P This article mentions the following:

Ionic liquids (ILs)-based organic-inorganic nanocomposite materials are a new class of hybrid materials which can be used in lithium batteries, fuel cells, dye-sensitized solar cells and pressure sensors. Halloysite nanotubes (HNTs, Al₂Si₂O₅(OH)₄·nH₂O) are hollow like aluminosilicate clay, similar to commonly used platy clay kaolin, which open up various attractive applications including catalysis, anticorrosion, adsorbent, drug delivery, enzyme immobilization, fiver spinning and so on. However, the inorganic characteristics of clay-based halloysite nanotube result in a limited application in electronic field, making it difficult to capture attentions as extensively as carbon nanotubes. Herein, we develop a feasible and versatiel approach to prepared ILs grafted HNTs, by coupling the arylboronic acid and Al-OH groups on the HNTs. ILs are grafted to the modified HNTs via a typical atom transfer radical polymerization (ATRP) method. The modified halloysite nanotubes (HNTs) are characterized by (FTIR), thermogravimetric anal., SEM and transmission electron microscope. In the experiment, the researchers used many compounds, for example, 1-Butyl-3-vinyl-1H-imidazol-3-ium hexafluorophosphate(V) (cas: 915358-85-9COA of Formula: C9H15F6N2P).

1-Butyl-3-vinyl-1H-imidazol-3-ium hexafluorophosphate(V) (cas: 915358-85-9) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with a This ring system is present in important biological building blocks, such as histidine and the related hormone histamine.COA of Formula: C9H15F6N2P

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Palladium(II) extraction using different ionic liquid-based aqueous biphasic systems was written by Song, Feiyue;Xue, Yongbo;Gao, Xin;Bai, Ling;Li, Jing;Deng, Yun;Xie, Lijuan;Ruan, Wenquan. And the article was included in Yingyong Huaxue in 2019.Application In Synthesis of 1-Methyl-3-propylimidazolium Chloride This article mentions the following:

To establish a green and efficient method to extract the precious metal palladium, we used an aqueous biphasic system(ABS) formed by “green solvent” ionic liquids and potassium phosphate to extract Pd(II) without addnl. extractants. We also determined the bimodal curves and tie-lines of 6 imidazolium-based ionic liquids by turbidity point method. The results indicate that there is no significant difference in phase forming ability and extraction rate between chloride-based and bromide-based ionic liquids The hydrophobicity of the side chain on the cation is one of the key factors affecting phase forming ability of ionic liquids Compared to ionic liquid without functional groups on the side chain of cation, the introduction of amino group and nitrile group on the side chain reduces the phase forming ability, but increases the extraction rate by 11.57% and 34.26%, resp. Moreover, the extraction rate by ionic liquid with nitrile group could reach 100% when the concentrations of ionic liquid and potassium phosphate were 5.00% and 39.55%, resp. The conclusions of this work could provide theor. basis and data support for the design or choose of ionic liquids for efficient extraction of palladium(II) by its aqueous biphasic system. In the experiment, the researchers used many compounds, for example, 1-Methyl-3-propylimidazolium Chloride (cas: 79917-89-8Application In Synthesis of 1-Methyl-3-propylimidazolium Chloride).

1-Methyl-3-propylimidazolium Chloride (cas: 79917-89-8) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with a Many drugs contain an imidazole ring, such as certain antifungal drugs, the nitroimidazole series of antibiotics, and the sedative midazolam.Application In Synthesis of 1-Methyl-3-propylimidazolium Chloride

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Radiosensitization of hypoxic mammalian cells in vitro by some 5-substituted-4-nitroimidazoles was written by Adams, G. E.;Fielden, E. M.;Hardy, C.;Millar, Barbara C.;Stratford, I. J.;Williamson, Christine. And the article was included in International Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine in 1981.Formula: C4H5N3O2 This article mentions the following:

The efficiencies of various of 5-substituted 4-nitroimidazoles (I) as radiation sensitizers were determined in hypoxic Chinese hamster cells irradiated in vitro, and compared with the previously published sensitizing properties of substituted 2-nitro- and 5-nitroimidazoles, some of the I showed unusually high sensitizing efficiencies defined as the concentrations required to give an enhancement ratio of 1.6. The equilibrium 1-electron reduction potentials of the compounds (E₇¹) were determined by a pulse radiolysis method, and the results showed that although sensitizing efficiencies were unexpectedly high, based on considerations of electron affinity, they still increase with increasing values of E₇¹. Enhancement ratios determined in 2 V79 cell lines for combinations of one of these compounds, NSC 38O87 (I, R = SO₂OPh) with various concentrations of misonidazole suggested that the 2 compounds may be operating by different mechanisms. In the experiment, the researchers used many compounds, for example, 1-Methyl-4-nitroimidazole (cas: 3034-41-1Formula: C4H5N3O2).

1-Methyl-4-nitroimidazole (cas: 3034-41-1) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with a Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).Formula: C4H5N3O2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem