Synthesis of cyclodextrin based hydrogel nanocarriers for enhanced solubility of candesartan cilexetil was written by Aslam, Afeefa;Bashir, Sajid;Sarfraz, Rai M.;Ahmad, Shahbaz. And the article was included in Latin American Journal of Pharmacy in 2019.COA of Formula: C33H34N6O6 This article mentions the following:
Nanoparticles are considered a useful tool for improving properties of poorly soluble active ingredients. In this work, successful efforts have been performed for solubility enhancement of candesartan. pH-sensitive hydroxypropyl β-cyclodextrin-poly acrylic acid (HPβCD-pAA) hydrogel nanoparticles were developed. Candesartan cilexetil, practically insoluble in water, was used as a model drug. Different formulations were prepared by free radical polymerization Developed nanoparticles were subjected to FTIR, DSC, TGA, PXRD, SEM, size anal., equilibrium swelling ratio (q), solubility studies, and in vitro drug release studies. pH dependent higher swelling and drug release was observed at pH 6.8 in less than 3 h. Solubility was improved up to 167.4 and 233.1 μg/mL in distilled water and PBS (pH 6.8) as compared to pure drug. The efficient preparation, high solubility, improved dissolution and pH responsive nature of prepared hydrogel nanoparticles can be a potential approach for delivery of poorly soluble drugs. In the experiment, the researchers used many compounds, for example, 1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate (cas: 145040-37-5COA of Formula: C33H34N6O6).
1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate (cas: 145040-37-5) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).COA of Formula: C33H34N6O6
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem