4-Aminoimidazole-5-carboxamide, precursor of the purines in E. coli was written by Ben-Ishai, Ruth;Volcani, Benjamin;Bergmann, Ernst D.. And the article was included in Archives of Biochemistry and Biophysics in 1951.Reference of 26832-08-6 This article mentions the following:
In the presence of only 4 γ/cc. of any of the purine bases, which by themselves gave only 30% growth, 4-aminoimidazole-5-carboxamide (I) (30γ) gave full growth. p-Aminobenzoic acid (0.1 γ/cc.) and 0.005 γ/cc. folic acid had no effect on the rate at which I was utilized but B12 (0.0002 γ/cc.) increased the rate of utilization. B12 had no effect in media containing adenine or other purine bases. The formyl derivative of I was more effective than I. In the experiment, the researchers used many compounds, for example, 1H-Imidazole-4-carboxamide (cas: 26832-08-6Reference of 26832-08-6).
1H-Imidazole-4-carboxamide (cas: 26832-08-6) belongs to imidazole derivatives. Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.n increase of the alkyl chain length of the alcohols. Reference of 26832-08-6
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem