Burilov, Vladimir A. et al. published their research in European Journal of Organic Chemistry in 2020 | CAS: 1632-83-3

1-Methylbenzimidazole (cas: 1632-83-3) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).Electric Literature of C8H8N2

Amphiphilic PdII-NHC Complexes on 1,3-Alternate p-tert-Butylthiacalix[4]arene Platform: Synthesis and Catalytic Activities in Coupling and Hydrogenation Reactions was written by Burilov, Vladimir A.;Gafiatullin, Bulat Kh.;Mironova, Diana A.;Sultanova, Elza D.;Evtugyn, Vladimir G.;Osin, Yuri N.;Islamov, Daut R.;Usachev, Konstantin S.;Solovieva, Svetlana E.;Antipin, Igor S.. And the article was included in European Journal of Organic Chemistry in 2020.Electric Literature of C8H8N2 This article mentions the following:

Herein the authors report the first example of amphiphilic PdII-NHC complexes on the thiacalix[4]arene backbone in 1,3-alternate configuration. Relative catalytic activity of synthesized PdII-NHC complexes in Suzuki-Miyaura coupling of haloarenes with phenylboronic acid was studied. A combination of micellar and metallocomplex catalysis was observed in Suzuki-Miyaura coupling upon going from pure DMF to water/DMF 3:1: the 2-fold increase of conversion of 4-bromoanisole unlike pure DMF was found. Interesting feature was found using chloroarene in DMF/water: the reaction selectivity changed from heterocoupling to homo coupling of phenylboronic acid. PdII-NHC complexes demonstrated a high activity in model hydrogenation reaction of p-nitrophenol using sodium borohydride. The most lipophilic PdII-NHC complex is most active, which can be attributed with addnl. p-nitrophenol preconcentration in the aggregates due to larger hydrophobic capacity of macrocycle. In the experiment, the researchers used many compounds, for example, 1-Methylbenzimidazole (cas: 1632-83-3Electric Literature of C8H8N2).

1-Methylbenzimidazole (cas: 1632-83-3) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).Electric Literature of C8H8N2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem