Orthogonality and compatibility between Tsc and Fmoc amino-protecting groups was written by Choi, Jin Seok;Kang, Hunhui;Jeong, Nakcheol;Han, Hogyu. And the article was included in Tetrahedron in 2005.Reference of 109012-23-9 This article mentions the following:
New deprotection conditions that provide a complete orthogonality between Tsc [2-(4-trifluoromethylphenylsulfonyl)ethoxycarbonyl] and Fmoc amino-protecting groups are described. The potential of these orthogonal deprotection conditions was then demonstrated by the efficient solid-phase synthesis of branched peptides I (n = 0 or 3) using doubly protected amino acids such as Tsc-Lys(Fmoc)-OH and Fmoc-Lys(Tsc)-OH. In the experiment, the researchers used many compounds, for example, Ethyl 1-methyl-4-nitro-1H-imidazole-2-carboxylate (cas: 109012-23-9Reference of 109012-23-9).
Ethyl 1-methyl-4-nitro-1H-imidazole-2-carboxylate (cas: 109012-23-9) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with a Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).Reference of 109012-23-9
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem