Concise and regioselective synthesis of 5H-imidazo[1,2-e][1,3,5]triazepines was written by Demydchuk, Bohdan A.;Mykhalchenko, Oleksandr A.;Rusanov, Eduard B.;Moskvina, Viktoriia S.;Brovarets, Volodymyr S.. And the article was included in ARKIVOC (Gainesville, FL, United States) in 2022.Application of 22600-77-7 This article mentions the following:
In this communication, a regioselective synthesis of novel 5H-imidazo[1,2-e][1,3,5]triazepines I (R = tert-Bu, Ph, 2-furyl, etc.) via the interaction of tetrachloro-2-aza-1,3-butadienes RC(Cl)=NC(Cl)=CCl2 with (1H-imidazol-2-yl)methanamine was reported. The advantages of the presented method are mild reaction conditions, a simple work-up procedure, available reagents, and high yields. A possible mechanism is proposed for the synthesis of key products. The structure of one of the obtained products was proven with a single crystal X-ray diffraction-based structure. In the experiment, the researchers used many compounds, for example, (1H-Imidazol-2-yl)methanamine dihydrochloride (cas: 22600-77-7Application of 22600-77-7).
(1H-Imidazol-2-yl)methanamine dihydrochloride (cas: 22600-77-7) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).Application of 22600-77-7
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem