Dore, Antonio et al. published their research in European Journal of Medicinal Chemistry in 2014 | CAS: 3012-80-4

1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde (cas: 3012-80-4) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. Imidazole is incorporated into many important biological compounds. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Histidine is present in many proteins and enzymes, e.g. by binding metal cofactors, as seen in hemoglobin.Name: 1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde

Synthesis and SAR study of novel tricyclic pyrazoles as potent phosphodiesterase 10A inhibitors was written by Dore, Antonio;Asproni, Battistina;Scampuddu, Alessia;Pinna, Gerard Aime;Christoffersen, Claus Tornby;Langgard, Morten;Kehler, Jan. And the article was included in European Journal of Medicinal Chemistry in 2014.Name: 1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde This article mentions the following:

Benzimidazoleethyl- and phenylimidazoleethyl-substituted pyrazolonaphthyridines and pyrazoloisoquinolines I (R = Me, F3C, EtO2C; R1 = 1-Me-4-Ph-2-imidazolyl, 1-Me-2-benzimidazolyl; X, Y, Z = N, CH) were prepared as potential selective phosphodiesterase 10A (PDE10A) inhibitors using a DL-proline and AgOTf-catalyzed and tosylhydrazine-mediated cyclocondensation reaction of methoxypropynylarylcarboxaldehydes with Me ketones to give fused pyrazolopyridines as the key step. I (R = Me; R1 = 1-Me-4-Ph-2-imidazolyl; X = N, CH; Y = CH, N; Z = CH), I (R = MeOCH2; R1 = 1-Me-4-Ph-2-imidazolyl; X = N; Y = Z = CH), and I (R = Me; R1 = 1-Me-4-Ph-2-imidazolyl; X = Y = CH; Z = N) showed the highest affinities for PDE10A with IC50 values of 40-55 nM. Mol. docking calculations and metabolic studies in human and rat liver microsomes were performed for selected compounds; the compounds were rapidly metabolized in liver microsomes. In the experiment, the researchers used many compounds, for example, 1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde (cas: 3012-80-4Name: 1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde).

1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde (cas: 3012-80-4) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. Imidazole is incorporated into many important biological compounds. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Histidine is present in many proteins and enzymes, e.g. by binding metal cofactors, as seen in hemoglobin.Name: 1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem