Enantioselective Mukaiyama-Michael Reaction Catalyzed by a Chiral Rhodium Complex Based on Pinene-Modified Pyridine Ligands was written by Gong, Jun;Wan, Qian;Kang, Qiang. And the article was included in Chemistry – An Asian Journal in 2018.Name: 1-(1-Methyl-1H-imidazol-2-yl)ethanone This article mentions the following:
The rhodium complex Λ-Rh1 containing chiral pinene-modified pyridine ligands was prepared through a two-step synthetic procedure; it exhibited excellent reactivity and enantiocontrol toward the enantioselective Mukaiyama-Michael reaction of α,β-unsaturated 2-acyl imidazoles with silyl enol ethers, affording enantioenriched 1,5-dicarbonyl compounds such as I [R = n-Bu, SEt, 4-FC6H4, etc.; R1 = i-Pr, Me; R2 = cyclopropyl, 2-thienyl, 4O2NC6H4, etc.] in good yields (up to 99 %) with excellent enantioselectivities (up to 99 % ee). In the experiment, the researchers used many compounds, for example, 1-(1-Methyl-1H-imidazol-2-yl)ethanone (cas: 85692-37-1Name: 1-(1-Methyl-1H-imidazol-2-yl)ethanone).
1-(1-Methyl-1H-imidazol-2-yl)ethanone (cas: 85692-37-1) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.n increase of the alkyl chain length of the alcohols. Name: 1-(1-Methyl-1H-imidazol-2-yl)ethanone
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem