Lewis acid-catalyzed asymmetric reactions of β,γ-unsaturated 2-acyl imidazoles was written by Kang, Tengfei;Hou, Liuzhen;Ruan, Sai;Cao, Weidi;Liu, Xiaohua;Feng, Xiaoming. And the article was included in Nature Communications in 2020.Application of 85692-37-1 This article mentions the following:
A regioselective catalytic asym. tandem isomerization/α-Michael addition of β,γ-unsaturated 2-acyl imidazoles in the presence of chiral N,N’-dioxide metal complexes, delivering a broad range of optically pure 1,5-dicarbonyl compounds with two vicinal tertiary carbon stereocenters such as I [R = Et, Ph, 3-thienyl, etc.] in up to > 99% ee under mild conditions. Meanwhile, stereodivergent synthesis was disclosed to yield all four stereoisomers of products. Control experiments suggested an isomerization process involved in reaction and gave an insight into the role of NEt3. In addition, Mannich reaction and sulfur-Michael addition of β,γ-unsaturated 2-acyl imidazoles proceeded smoothly as well under same catalytic systemto give functionalized carbonyl compounds II [R1 = n-Pr, Ph, 4-ClC6H4, etc.; R2 = n-Bu, CH2CO2Me, 2-naphthyl, etc.]. In the experiment, the researchers used many compounds, for example, 1-(1-Methyl-1H-imidazol-2-yl)ethanone (cas: 85692-37-1Application of 85692-37-1).
1-(1-Methyl-1H-imidazol-2-yl)ethanone (cas: 85692-37-1) belongs to imidazole derivatives. Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar. This ring system is present in important biological building blocks, such as histidine and the related hormone histamine.Application of 85692-37-1
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem