Development and evaluation of floating microspheres containing candesartan cilexetil was written by Madhuri, Md;Manjunath, K.;Kulkarni, Suresh V.. And the article was included in American Journal of PharmTech Research in 2019.Recommanded Product: 145040-37-5 This article mentions the following:
The aim of the present study is to develop and evaluate floating microspheres containing candesartan cilexetil in order to achieve extended release of drug and thereby to enhance the patient compliance. Floating microspheres were prepared by using solvent evaporation method. The microspheres were formulated using different polymers like Et cellulose, HPMC K4M and eudragit RSPO 100 in different concentrations and combinations. The prepared floating microspheres were characterized for their percentage yield (95.44 – 98.52%), drug entrapment efficiencies (71.52 – 97.87%) and percentage buoyancy (93.45 – 98.66%). The FTIR and DSC studies revealed absence of interactions between drug and selected polymers. In vitro release studies were performed in 0.1 N HCl which showed a drug release of 97.62% at 24 h in case of formulation (F7). Fitting the in vitro drug release data to Korsmeyer equation indicated that Fickian diffusion is the mechanism of drug release. In the experiment, the researchers used many compounds, for example, 1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate (cas: 145040-37-5Recommanded Product: 145040-37-5).
1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate (cas: 145040-37-5) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole has been usedin the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein, in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography, as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells.Recommanded Product: 145040-37-5
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem