Inhibition of rat hepatic microsomal aminopyrine N-demethylase activity by benzimidazole derivatives. Quantitative structure-activity relationships was written by Murray, Michael;Ryan, Adrian J.;Little, Peter J.. And the article was included in Journal of Medicinal Chemistry in 1982.Synthetic Route of C8H8N2 This article mentions the following:
Eighty-two benzimidazole derivatives, some which were synthesized, were tested for the ability to inhibit cytochrome P-450 mediated enzyme activity, specifically aminopyrine N-demethylase [9037-69-8], from phenobarbitone-induced rat hepatic microsomes. Using physicochem. parameters and multiple regression anal., a quant. structure-activity relationship (QSAR) that describes up to 87% of the data variance in terms of hydrophobic and electronic effects and the molar refractivity of the substituent in the 2-position of the benzimidazole ring is presented. In the experiment, the researchers used many compounds, for example, 7-Methyl-1H-benzo[d]imidazole (cas: 4887-83-6Synthetic Route of C8H8N2).
7-Methyl-1H-benzo[d]imidazole (cas: 4887-83-6) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. Imidazole also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes.Synthetic Route of C8H8N2
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem