Antimicrobial Activity and SAR Study of New Gemini Imidazolium-Based Chlorides was written by Palkowski, Lukasz;Blaszczynski, Jerzy;Skrzypczak, Andrzej;Blaszczak, Jan;Kozakowska, Karolina;Wroblewska, Joanna;Kozuszko, Sylwia;Gospodarek, Eugenia;Krysinski, Jerzy;Slowinski, Roman. And the article was included in Chemical Biology & Drug Design in 2014.Application In Synthesis of 1-Octyl-1H-imidazole This article mentions the following:
A series of seventy new 3,3′-(α,ω-dioxaalkyl)bis[1-(alkyl)imidazolium] chloride derivatives was prepared They were characterized with respect to surface active properties and antimicrobial activity against the following pathogens: Staphylococcus aureus, Enterococcus faecalis, Acinetobacter baumannii, Escherichia coli, Klebsiella pneumoniae, Enterobacter cloacae, Pseudomonas aeruginosa, Candida krusei and Candida albicans. In this article, besides description of the synthesis, the authors characterize a set of features of these compounds, concerning their structure (described by the length of the dioxaalkane spacer and the length of the alkyl substituent in the aromatic ring) and surface active properties (critical micelle concentration, value of surface tension at critical micelle concentration, value of surface excess, mol. area of a single particle, and free energy of adsorption of mol.). Then, the authors present a SAR study for Staphylococcus aureus, as one of the most widespread pathogenic strains, conducted with the help of the Dominance-based Rough Set Approach (DRSA), that involves identification of relevant features and relevant combinations of features being in strong relationship with a high antimicrobial activity of the compounds The SAR study shows, moreover, that the antimicrobial activity is dependent on the type of substituents and their position at the chloride moiety, as well as on the surface active properties of the compounds The synthesis of the target compounds was achieved by a reaction of 1-(alkyl)-1H-imidazole derivatives with 1,5-bis(chloromethoxy)pentane, 1,6-bis(chloromethoxy)hexane, 1,3-bis(chloromethoxy)propane, etc. The title compounds thus formed included 1,1′-[1,2-ethanediylbis(oxymethylene)]bis[3-octyl-1H-imidazolium] dichloride and related substances, such as 1,1′-[1,4-butanediylbis(oxymethylene)]bis[3-octyl-1H-imidazolium] dichloride, [(alkanediyl)bis[(oxy)methylene]]bis[(alkyl)imidazolium] dichloride derivatives (imidazolium chloride dimers). In the experiment, the researchers used many compounds, for example, 1-Octyl-1H-imidazole (cas: 21252-69-7Application In Synthesis of 1-Octyl-1H-imidazole).
1-Octyl-1H-imidazole (cas: 21252-69-7) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. Many drugs contain an imidazole ring, such as certain antifungal drugs, the nitroimidazole series of antibiotics, and the sedative midazolam.Application In Synthesis of 1-Octyl-1H-imidazole
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem