Nucleophilic C-H Etherification of Heteroarenes Enabled by Base-Catalyzed Halogen Transfer was written by Puleo, Thomas R.;Klaus, Danielle R.;Bandar, Jeffrey S.. And the article was included in Journal of the American Chemical Society in 2021.Computed Properties of C8H8N2 This article mentions the following:
A general protocol for the direct C-H etherification of N-heteroarenes is reported. Potassium tert-butoxide catalyzes halogen transfer from 2-halothiophenes to N-heteroarenes to form N-heteroaryl halide intermediates that undergo tandem base-promoted alc. substitution. Thus, the simple inclusion of inexpensive 2-halothiophenes enables regioselective oxidative coupling of alcs. with 1,3-azoles, pyridines, diazines, and polyazines under basic reaction conditions. In the experiment, the researchers used many compounds, for example, 1-Methylbenzimidazole (cas: 1632-83-3Computed Properties of C8H8N2).
1-Methylbenzimidazole (cas: 1632-83-3) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with a This ring system is present in important biological building blocks, such as histidine and the related hormone histamine.Computed Properties of C8H8N2
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem