A re-examination of the genotoxicity and carcinogenicity of azathioprine. Comments was written by Rosenkranz, Herbert S.;Klopman, Gilles. And the article was included in Mutation Research, Fundamental and Molecular Mechanisms of Mutagenesis in 1991.Product Details of 3034-41-1 This article mentions the following:
CASE, a novel artificial intelligence structure-activity relational method of anal., was used to study the structural basis of carcinogenicity of azathioprine. The criteria that were analyzed predicted azathioprine to be a genotoxic carcinogen. In addition, 6-mercaptopurine and 1-methyl-4-nitroimidazole, both moieties of azathioprine, were predicted to have mutagenic potential. In the experiment, the researchers used many compounds, for example, 1-Methyl-4-nitroimidazole (cas: 3034-41-1Product Details of 3034-41-1).
1-Methyl-4-nitroimidazole (cas: 3034-41-1) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with a This ring system is present in important biological building blocks, such as histidine and the related hormone histamine.Product Details of 3034-41-1
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem