Experimental memory disorders and their pharmacological correction was written by Shabanov, P. D.. And the article was included in Vestnik Akademii Meditsinskikh Nauk SSSR in 1985.Name: 1H-Imidazole-4-carboxamide This article mentions the following:
The antiamnesic action of a variety of neurotropic drugs on 2 models of memory disorders (electronconvulsive shock and mech. brain injury) was studied in rats. GABA (200 mg/kg) and 1-methyl-3,4-di-(N-methylcarbamoyl)-pyrazole (10 μg/kg) were the most potent drugs inhibiting amnesia for passive avoidance. Piracetam (100 mg/kg) and etimazole (1.5 mg/kg) were compared for effects on learning and memory of the drinking conditioned reflex under conditions of RNA synthesis inhibition by actinomycin D. Neither compound affected learning but facilitated it after actinomycin D administration. Both drugs also increased memory retention. In the experiment, the researchers used many compounds, for example, 1H-Imidazole-4-carboxamide (cas: 26832-08-6Name: 1H-Imidazole-4-carboxamide).
1H-Imidazole-4-carboxamide (cas: 26832-08-6) belongs to imidazole derivatives. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs. Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).Name: 1H-Imidazole-4-carboxamide
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem