Benzimidazolium-acridine-based silver N-heterocyclic carbene complexes as potential anti-bacterial and anti-cancer drug was written by Sharhan, Olla;Heidelberg, Thorsten;Hashim, Najihah Mohd.;Al-Madhagi, Wafa M.;Ali, Hapipah Mohd.. And the article was included in Inorganica Chimica Acta in 2020.Computed Properties of C8H8N2 This article mentions the following:
A series of N-alkylated benzimidazolium salts based on 9-substituted acridine has been synthesized and subsequently converted into the corresponding Ag(I) carbene complexes. The compounds were characterized by IR, 1H and 13C NMR spectroscopy. Identity and purity were confirmed by HRMS and elemental anal., resp. Both, ligands and complexes, were evaluated on their antibacterial and anticancer potential. All complexes exhibited higher activity against both Gram pos. and Gram neg. bacterial strains than the corresponding ligands. Human cell line experiments indicated low in-vitro cytotoxicity, while some of the complexes showed promising activity against breast cancer cells. In the experiment, the researchers used many compounds, for example, 1-Methylbenzimidazole (cas: 1632-83-3Computed Properties of C8H8N2).
1-Methylbenzimidazole (cas: 1632-83-3) belongs to imidazole derivatives. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs. Imidazole is incorporated into many important biological compounds. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Histidine is present in many proteins and enzymes, e.g. by binding metal cofactors, as seen in hemoglobin.Computed Properties of C8H8N2
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem