Organocatalytic Enantioselective Conjugate Alkynylation of β-Aminoenones: Access to Chiral β-Alkynyl-β-Amino Carbonyl Derivatives was written by Wang, Jian-Fei;Meng, Xin;Zhang, Chao-Huan;Yu, Chuan-Ming;Mao, Bin. And the article was included in Organic Letters in 2020.Application of 1632-83-3 This article mentions the following:
Readily available potassium alkynyltrifluoroborates were used for organocatalytic asym. conjugate alkynylation of β-enaminones. The interception of a modified binaphthol catalyst and in situ generated organodifluoroboranes proved important to access functionalized β-alkynyl-β-amino carbonyls and derivatives with improved chemo-reactivity and enantio-induction. Mechanistic studies revealed the impact of mol. sieves on efficiency and stereocontrol. The products undergo addnl. functionalization to yield a diverse set of valuable β-alkynyl-β-amino carbonyl scaffolds. In the experiment, the researchers used many compounds, for example, 1-Methylbenzimidazole (cas: 1632-83-3Application of 1632-83-3).
1-Methylbenzimidazole (cas: 1632-83-3) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes.Application of 1632-83-3
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem