Benzimidazole- and Imidazole-Fused Selenazolium and Selenazinium Selenocyanates: Ionic Organoselenium Compounds with Efficient Peroxide Scavenging Activities was written by Banerjee, Kaustav;Bhattacherjee, Debojit;Mahato, Sulendar K.;Sufian, Abu;Bhabak, Krishna Pada. And the article was included in Inorganic Chemistry in 2021.Computed Properties of C8H8N2 This article mentions the following:
Three new classes of ionic organoselenium compounds containing cationic benzimidazolium and imidazolium ring systems with selenocyanates as counterions are described. The cyclization of N,N’-disubstituted benzimidazolium and imidazolium bromides having N-(CH2)2-Br and N-(CH2)3-Br groups in the presence of potassium selenocyanate (KSeCN) led to formation of the corresponding selenazolium selenocyanates Iâ?sup>-SeCN [R = Me, Bn; R1 = R2 = H, R1R2 = (CH)4; n = 1] and selenazinium selenocyanates Iâ?sup>-SeCN [n = 2]. However, the open-chain selenocyanates with addnl. selenocyanate counterions IIâ?sup>-SeCN were formed from the N,N’-disubstituted benzimidazolium and imidazolium bromides having N-(CH2)6-Br groups. Mechanistic studies were carried out to understand the feasibility of such cyclization processes in the presence of KSeCN. The compounds were studied further for their potencies to catalytically reduce H2O2 in the presence of thiols. Interestingly, the cyclic selenazolium Iâ?sup>-SeCN [n = 1] and selenazinium compounds Iâ?sup>-SeCN [n = 2] exhibited significantly higher antioxidant activities than the corresponding acyclic selenocyanates II. Selected compounds Iâ?sup>-SeCN [R = Bn; R1R2 = (CH)4; n = 2] and IIâ?sup>-SeCN [R = Me; R1R2 = (CH)4] were further evaluated for their potencies in modulating the intracellular level of reactive oxygen species (ROS) in a representative macrophage cell line (RAW 264.7). Owing to the cationic nature of compounds, they may target and scavenge mitochondrial ROS in the cellular medium. In the experiment, the researchers used many compounds, for example, 1-Methylbenzimidazole (cas: 1632-83-3Computed Properties of C8H8N2).
1-Methylbenzimidazole (cas: 1632-83-3) belongs to imidazole derivatives. Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar. Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).Computed Properties of C8H8N2
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem