Substituent effects on proton affinities: through bonds or through space mechanism? was written by Catalan, Javier;Perez, Pilar;Elguero, Jose. And the article was included in Heterocycles in 1983.SDS of cas: 3034-41-1 This article mentions the following:
INDO calculations of the protonation energies and lone pair orbital energies of twenty pyrazoles and twenty imidazoles have been carried out in order to ascertain the mechanism of the substituent effect; Me, cyano, fluoro, amino, and nitro substituents have been examined The nitro group shows a special behavior. The importance of optimizing the geometry and the reasons for the anomaly shown by the nitro derivatives are discussed. In the experiment, the researchers used many compounds, for example, 1-Methyl-4-nitroimidazole (cas: 3034-41-1SDS of cas: 3034-41-1).
1-Methyl-4-nitroimidazole (cas: 3034-41-1) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.SDS of cas: 3034-41-1
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem