Nsc-mediated solid-phase synthesis of polyamides containing pyrrole amino acid was written by Choi, Jin Seok;Lee, Hwa-Sun;Lee, Younjoo;Jeong, Nakcheol;Kim, Hack-Joo;Kim, Young-Deug;Han, Hogyu. And the article was included in Tetrahedron Letters in 2002.Quality Control of Ethyl 1-methyl-4-nitro-1H-imidazole-2-carboxylate This article mentions the following:
The synthesis of the Nsc-protected amino acid, Nsc-Py-OH (I) [Nsc = 2-(4-nitrophenylsulfonyl)ethoxycarbonyl] and its oligomerization on solid-phase are described. The suitability of the Nsc methodol. for preparation of polyamides containing heteroaromatic amino acids was demonstrated. In the experiment, the researchers used many compounds, for example, Ethyl 1-methyl-4-nitro-1H-imidazole-2-carboxylate (cas: 109012-23-9Quality Control of Ethyl 1-methyl-4-nitro-1H-imidazole-2-carboxylate).
Ethyl 1-methyl-4-nitro-1H-imidazole-2-carboxylate (cas: 109012-23-9) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. Many drugs contain an imidazole ring, such as certain antifungal drugs, the nitroimidazole series of antibiotics, and the sedative midazolam.Quality Control of Ethyl 1-methyl-4-nitro-1H-imidazole-2-carboxylate
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem