One atom linch pin transformations of Gold’s reagent was written by Gupton, John T.;Correia, Keith F.;Foster, Bruce S.. And the article was included in Synthetic Communications in 1986.Computed Properties of C8H8N2 This article mentions the following:
A series of o-phenylenediamines I (Z = NH, R = H, R1 = 4-Me; R = R1 = H; 4-, 5-Me) and o-aminophenols I (Z = O, R = R1 = H; R = H, R1 = 4-, 5-Me) reacted with Gold’s reagent to yield benzimidazoles II (Z = NH) and benzoxazoles II (Z = O) resp. Addnl., o-hydroxyacetophenone and anthranilamide, when reacted with Gold’s reagent, gave chromone and 3H-quinazoline-4-one, resp. These transformations represent the use of Gold’s reagent as a one atom linchpin. In the experiment, the researchers used many compounds, for example, 7-Methyl-1H-benzo[d]imidazole (cas: 4887-83-6Computed Properties of C8H8N2).
7-Methyl-1H-benzo[d]imidazole (cas: 4887-83-6) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with a Imidazole has been usedin the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein, in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography, as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells.Computed Properties of C8H8N2
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem