Cu-Catalyzed Regioselective C-H Alkylation of Benzimidazoles with Aromatic Alkenes was written by He, Yu-Ting;Mao, Yang-Jie;Hao, Hong-Yan;Xu, Zhen-Yuan;Lou, Shao-Jie;Xu, Dan-Qian. And the article was included in Organic Letters in 2020.Computed Properties of C8H8N2 This article mentions the following:
Herein we report a novel Cu-catalyzed regioselective C2-H alkylation of benzimidazoles such as N-methylbenzimidazole with aromatic alkenes. The reaction features exclusive regioselectivity and broad substrate scope in the intermol. alkylation of benzimidazoles with terminal and internal aromatic alkenes, constituting a modular access toward benzimidazole-containing 1,1-di(hetero)aryl alkanes such as I. The intramol. C2-H alkylation of benzimidazoles with aromatic alkenes such as N-cinnamylbenzimidazole has been achieved in an endo-selective manner to yield fused benzimidazoles such as cyclopentapyrrolobenzimidazole II. The enantioselective C2 alkylation of benzimidazoles has also been realized with moderate to good stereocontrol; for example, using (S,S)-Ph-BPE, (+)-I and (+)-II were prepared in 85:15 er and 68:32 er, resp. In the experiment, the researchers used many compounds, for example, 1-Methylbenzimidazole (cas: 1632-83-3Computed Properties of C8H8N2).
1-Methylbenzimidazole (cas: 1632-83-3) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.Computed Properties of C8H8N2
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem