Synthesis and Toxicity Evaluation of New Pyrroles Obtained by the Reaction of Activated Alkynes with 1-Methyl-3-(cyanomethyl)benzimidazolium Bromide was written by Ivan, Beatrice-Cristina;Dumitrascu, Florea;Anghel, Adriana Iuliana;Ancuceanu, Robert Viorel;Shova, Sergiu;Dumitrescu, Denisa;Draghici, Constantin;Olaru, Octavian Tudorel;Nitulescu, George Mihai;Dinu, Mihaela;Barbuceanu, Stefania-Felicia. And the article was included in Molecules in 2021.Category: imidazoles-derivatives This article mentions the following:
A series of new pyrrole derivatives I (R = H, methoxycarbonyl, ethoxycarbonyl; R1 = Bz, methoxycarbonyl, ethoxycarbonyl, (propan-2-yloxy)carbonyl) were designed as chem. analogs of the 1,4-dihydropyridines drugs in order to develop future new calcium channel blockers. The new tri- and tetra-substituted N-arylpyrroles I were synthesized by the one-pot reaction of 1-methyl-3-cyanomethyl benzimidazolium bromide with substituted alkynes RCCR1 having at least one electron-withdrawing substituent, in 1,2-epoxybutane, acting both as the solvent and reagent to generate the corresponding benzimidazolium N3-ylide. The structural characterization of the new substituted pyrroles I was based on IR, NMR spectroscopy as well as on single crystal X-ray anal. The toxicity of the new compounds was assessed on the plant cell using Triticum aestivum L. species and on the animal cell using Artemia franciscana Kellogg and Daphnia magna Straus crustaceans. The compounds showed minimal phytotoxicity on Triticum rootlets and virtually no acute toxicity on Artemia nauplii, while on Daphnia magna, it induced moderate to high toxicity, similar to nifedipine. This research indicates that the newly synthesized pyrrole derivatives are promising mols. with biol. activity and low acute toxicity. In the experiment, the researchers used many compounds, for example, 1-Methylbenzimidazole (cas: 1632-83-3Category: imidazoles-derivatives).
1-Methylbenzimidazole (cas: 1632-83-3) belongs to imidazole derivatives. Imidazole is the basic core of some natural products such as histidine, purine, histamine and DNA based structures, etc. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.n increase of the alkyl chain length of the alcohols. Category: imidazoles-derivatives
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem